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Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.
Jungverdorben J, Till A, Brüstle O. Jungverdorben J, et al. J Mol Med (Berl). 2017 Jul;95(7):705-718. doi: 10.1007/s00109-017-1533-5. Epub 2017 Jun 7. J Mol Med (Berl). 2017. PMID: 28593578 Free PMC article. Review.
The advent of cell reprogramming has enabled the generation of induced pluripotent stem cells (iPSCs) from patient skin fibroblasts or blood cells and their subsequent differentiation into tissue-specific cells, including neurons and glia. ...Here, we …
The advent of cell reprogramming has enabled the generation of induced pluripotent stem cells (iPSCs) from patie …
Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease.
Weykopf B, Haupt S, Jungverdorben J, Flitsch LJ, Hebisch M, Liu GH, Suzuki K, Belmonte JCI, Peitz M, Blaess S, Till A, Brüstle O. Weykopf B, et al. Eur J Neurosci. 2019 Feb;49(4):561-589. doi: 10.1111/ejn.14345. Eur J Neurosci. 2019. PMID: 30656775 Free PMC article. Review.
Importantly, recent progress in genome-editing technologies has provided an ability to analyze isogenic induced pluripotent stem cell (iPSC) pairs that differ only in a single genetic change, thus allowing a thorough assessment of the molecular and cel …
Importantly, recent progress in genome-editing technologies has provided an ability to analyze isogenic induced pluripotent
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