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Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, Hanley NA, Hay DC, Ingelman-Sundberg M, Juhila S, Kitteringham N, Silva-Lima B, Norris A, Pridgeon C, Ross JA, Young RS, Tagle D, Tornesi B, van de Water B, Weaver RJ, Zhang F, Park BK. Goldring C, et al. Hepatology. 2017 Feb;65(2):710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30. Hepatology. 2017. PMID: 27775817 Free PMC article. Review.
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju A, Copple IM, Bryan HK, Edge GT, Sison RL, Wong MW, Lai ZQ, Lin ZX, Dunn K, Sanderson CM, Alghanem AF, Cross MJ, Ellis EC, Ingelman-Sundberg M, Malik HZ, Kitteringham NR, Goldring CE, Park BK. Olayanju A, et al. Free Radic Biol Med. 2015 Jan;78:202-12. doi: 10.1016/j.freeradbiomed.2014.11.003. Epub 2014 Nov 14. Free Radic Biol Med. 2015. PMID: 25445704 Free PMC article.
Stem cell-derived systems in toxicology assessment.
Suter-Dick L, Alves PM, Blaauboer BJ, Bremm KD, Brito C, Coecke S, Flick B, Fowler P, Hescheler J, Ingelman-Sundberg M, Jennings P, Kelm JM, Manou I, Mistry P, Moretto A, Roth A, Stedman D, van de Water B, Beilmann M. Suter-Dick L, et al. Stem Cells Dev. 2015 Jun 1;24(11):1284-96. doi: 10.1089/scd.2014.0540. Epub 2015 Mar 31. Stem Cells Dev. 2015. PMID: 25675366 Review.
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.
Sison-Young RL, Mitsa D, Jenkins RE, Mottram D, Alexandre E, Richert L, Aerts H, Weaver RJ, Jones RP, Johann E, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Kitteringham NR, Park BK. Sison-Young RL, et al. Toxicol Sci. 2015 Oct;147(2):412-24. doi: 10.1093/toxsci/kfv136. Epub 2015 Jul 8. Toxicol Sci. 2015. PMID: 26160117 Free PMC article.
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Bell CC, Hendriks DF, Moro SM, Ellis E, Walsh J, Renblom A, Fredriksson Puigvert L, Dankers AC, Jacobs F, Snoeys J, Sison-Young RL, Jenkins RE, Nordling Å, Mkrtchian S, Park BK, Kitteringham NR, Goldring CE, Lauschke VM, Ingelman-Sundberg M. Bell CC, et al. Sci Rep. 2016 May 4;6:25187. doi: 10.1038/srep25187. Sci Rep. 2016. PMID: 27143246 Free PMC article.
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Sison-Young RL, Lauschke VM, Johann E, Alexandre E, Antherieu S, Aerts H, Gerets HHJ, Labbe G, Hoët D, Dorau M, Schofield CA, Lovatt CA, Holder JC, Stahl SH, Richert L, Kitteringham NR, Jones RP, Elmasry M, Weaver RJ, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Park BK. Sison-Young RL, et al. Arch Toxicol. 2017 Mar;91(3):1385-1400. doi: 10.1007/s00204-016-1745-4. Epub 2016 Jun 25. Arch Toxicol. 2017. PMID: 27344343 Free PMC article.
539 results