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Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.
Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Evgenov OV, et al. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1138-45. doi: 10.1164/rccm.200707-1121OC. Epub 2007 Sep 13. Am J Respir Crit Care Med. 2007. PMID: 17872487 Free PMC article.
RATIONALE: Nitric oxide-independent agonists of soluble guanylate cyclase (sGC) have been developed. OBJECTIVES: We tested whether inhalation of novel dry-powder microparticle formulations containing sGC stimulators (BAY 41-2272, BAY 41-8543) or …
RATIONALE: Nitric oxide-independent agonists of soluble guanylate cyclase (sGC) have been developed. OBJECTIVES: …
Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs.
Evgenov OV, Ichinose F, Evgenov NV, Gnoth MJ, Falkowski GE, Chang Y, Bloch KD, Zapol WM. Evgenov OV, et al. Circulation. 2004 Oct 12;110(15):2253-9. doi: 10.1161/01.CIR.0000144469.01521.8A. Epub 2004 Oct 4. Circulation. 2004. PMID: 15466650
BACKGROUND: Inhaled nitric oxide (NO) is a potent and selective pulmonary vasodilator, which induces cGMP synthesis by activating soluble guanylate cyclase (sGC) in ventilated lung regions. ...Furthermore, infusing BA …
BACKGROUND: Inhaled nitric oxide (NO) is a potent and selective pulmonary vasodilator, which induces cGMP …
Inhaled nitric oxide pretreatment but not posttreatment attenuates ischemia-reperfusion-induced pulmonary microvascular leak.
Chetham PM, Sefton WD, Bridges JP, Stevens T, McMurtry IF. Chetham PM, et al. Anesthesiology. 1997 Apr;86(4):895-902. doi: 10.1097/00000542-199704000-00020. Anesthesiology. 1997. PMID: 9105234
Cyclic adenosine monophosphate (cAMP) agonists reverse and prevent I/R-induced microvascular leak, but reversal by inhaled NO (INO) has not been tested. In addition, the role of soluble guanylyl cyclase (sGC) activation in the NO protecti …
Cyclic adenosine monophosphate (cAMP) agonists reverse and prevent I/R-induced microvascular leak, but reversal by inhaled …