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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Anastasiou D, et al. Science. 2011 Dec 2;334(6060):1278-83. doi: 10.1126/science.1211485. Epub 2011 Nov 3. Science. 2011. PMID: 22052977 Free PMC article.
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibition of the glycolytic enzy …
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer cell survival. We show tha …
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension.
Guo D, Gu J, Jiang H, Ahmed A, Zhang Z, Gu Y. Guo D, et al. J Mol Cell Cardiol. 2016 Feb;91:179-87. doi: 10.1016/j.yjmcc.2016.01.009. Epub 2016 Jan 13. J Mol Cell Cardiol. 2016. PMID: 26774701
METHODS AND RESULTS: By Western blots, we showed that increased intracellular ROS caused inhibition of the glycolytic pyruvate kinase M2 (PKM2) activity through promoting the phosphorylation of PKM2. ...CONCLUSION: Our data provide new evidence that PK …
METHODS AND RESULTS: By Western blots, we showed that increased intracellular ROS caused inhibition of the glycolytic pyruvate
Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth.
Xiangyun Y, Xiaomin N, Linping G, Yunhua X, Ziming L, Yongfeng Y, Zhiwei C, Shun L. Xiangyun Y, et al. Oncotarget. 2017 Jan 24;8(4):6984-6993. doi: 10.18632/oncotarget.14346. Oncotarget. 2017. PMID: 28036303 Free PMC article.
Tumor cells trends to express high level of pyruvate kinase M2 (PKM2). The inhibition of PKM2 activity is needed for antioxidant response by diverting glucose flux into the pentose phosphate pathway and thus generating sufficient r …
Tumor cells trends to express high level of pyruvate kinase M2 (PKM2). The inhibition of PKM2 activity is …
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