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Innovative preparation of curcumin for improved oral bioavailability.
Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T. Sasaki H, et al. Biol Pharm Bull. 2011;34(5):660-5. doi: 10.1248/bpb.34.660. Biol Pharm Bull. 2011. PMID: 21532153 Free article. Clinical Trial.
The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentration-time curve (AUC) after the oral administration of THERACURMIN was found to be more than 40-fold higher than that of curcumin …
The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentra …
Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry.
Zhang Q, Polyakov NE, Chistyachenko YS, Khvostov MV, Frolova TS, Tolstikova TG, Dushkin AV, Su W. Zhang Q, et al. Drug Deliv. 2018 Nov;25(1):198-209. doi: 10.1080/10717544.2017.1422298. Drug Deliv. 2018. PMID: 29302995 Free PMC article.
An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na(2)GA) was prepared by mechanical ball milling. ...Further pharmacokinetic study of this SD formulation in rat showed a significant 19-fold increase of bioavailability as compa …
An amorphous solid dispersion (SD) of curcumin (Cur) with disodium glycyrrhizin (Na(2)GA) was prepared by mechanical ball mill …
A combination of complexation and self-nanoemulsifying drug delivery system for enhancing oral bioavailability and anticancer efficacy of curcumin.
Shukla M, Jaiswal S, Sharma A, Srivastava PK, Arya A, Dwivedi AK, Lal J. Shukla M, et al. Drug Dev Ind Pharm. 2017 May;43(5):847-861. doi: 10.1080/03639045.2016.1239732. Epub 2016 Oct 6. Drug Dev Ind Pharm. 2017. PMID: 27648633
However, poor oral bioavailability is the major hurdle in its clinical application. ...The combined use of both the approaches has been explored for the first time to enhance the oral bioavailability and in turn increase the anticancer activity of c …
However, poor oral bioavailability is the major hurdle in its clinical application. ...The combined use of both the approaches …
Preparation, physicochemical and pharmacological study of curcumin solid dispersion with an arabinogalactan complexation agent.
Zhang Q, Suntsova L, Chistyachenko YS, Evseenko V, Khvostov MV, Polyakov NE, Dushkin AV, Su W. Zhang Q, et al. Int J Biol Macromol. 2019 May 1;128:158-166. doi: 10.1016/j.ijbiomac.2019.01.079. Epub 2019 Jan 18. Int J Biol Macromol. 2019. PMID: 30664966
Pharmaceutical solid dispersions (SD) of curcumin (Cur) with macromolecule polysaccharide arabinogalactan (AG) from wood of Larix sibirica were prepared by mechanical ball milling. ...Pharmacokinetic study of Cur-AG SD formulation in rat demonstrated a significant~8 …
Pharmaceutical solid dispersions (SD) of curcumin (Cur) with macromolecule polysaccharide arabinogalactan (AG) from wood of Larix sib …
Evaluation of Intestinal Absorption Mechanism and Pharmacokinetics of Curcumin-Loaded Galactosylated Albumin Nanoparticles.
Huang Y, Deng S, Luo X, Liu Y, Xu W, Pan J, Wang M, Xia Z. Huang Y, et al. Int J Nanomedicine. 2019 Dec 10;14:9721-9730. doi: 10.2147/IJN.S229992. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31849464 Free PMC article.
METHODS: The present work chose the prepared curcumin-loaded galactosylated albumin nanoparticles (Gal-BSA NPs) as the nano-drug samples to study the intestinal capacity and the oral bioavailability. ...CONCLUSION: All results demonstrated that Gal-BSA …
METHODS: The present work chose the prepared curcumin-loaded galactosylated albumin nanoparticles (Gal-BSA NPs) as the nano-dr …
Metabolic fate of poly-(lactic-co-glycolic acid)-based curcumin nanoparticles following oral administration.
Harigae T, Nakagawa K, Miyazawa T, Inoue N, Kimura F, Ikeda I, Miyazawa T. Harigae T, et al. Int J Nanomedicine. 2016 Jun 28;11:3009-22. doi: 10.2147/IJN.S107442. eCollection 2016. Int J Nanomedicine. 2016. PMID: 27418823 Free PMC article.
PURPOSE: Curcumin (CUR), the main polyphenol in turmeric, is poorly absorbed and rapidly metabolized following oral administration, which severely curtails its bioavailability. ...CONCLUSION: These findings provide a better understanding of the bioavailabi …
PURPOSE: Curcumin (CUR), the main polyphenol in turmeric, is poorly absorbed and rapidly metabolized following oral administra …
Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin.
Catalan-Latorre A, Ravaghi M, Manca ML, Caddeo C, Marongiu F, Ennas G, Escribano-Ferrer E, Peris JE, Diez-Sales O, Fadda AM, Manconi M. Catalan-Latorre A, et al. Eur J Pharm Biopharm. 2016 Oct;107:49-55. doi: 10.1016/j.ejpb.2016.06.016. Epub 2016 Jun 25. Eur J Pharm Biopharm. 2016. PMID: 27349806
This work aimed at finding an innovative vesicle-type formulation able to improve the bioavailability of curcumin upon oral administration. ...For the first time, the two polymers were combined in a system intended for oral delivery, to e …
This work aimed at finding an innovative vesicle-type formulation able to improve the bioavailability of curcumin …
Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex.
Song W, Chen X, Dai C, Lin D, Pang X, Zhang D, Liu G, Jin Y, Lin J. Song W, et al. Molecules. 2022 May 7;27(9):2998. doi: 10.3390/molecules27092998. Molecules. 2022. PMID: 35566349 Free PMC article.
However, the application of curcumin for animal production and human life is limited by a low oral bioavailability. ...This confirmed that CUR-beta-CD, CUR-HSPC, and especially CUR-PEG-6000 could effectively improve the bioavailability of cur …
However, the application of curcumin for animal production and human life is limited by a low oral bioavailability. ... …
Dihydroartemesinin and Curcumin Based Self-Microemulsifying Drug Delivery System for Antimalarial Activity.
Srivastava R, Fatima Z, Sahoo J, Joshi P, Tripathi R. Srivastava R, et al. Drug Res (Stuttg). 2022 Nov;72(9):500-508. doi: 10.1055/a-1879-2758. Epub 2022 Aug 11. Drug Res (Stuttg). 2022. PMID: 35952683
A new self-micro emulsifying drug delivery system has been developed to improve the solubility of dihydroartemisinin and curcumin. The prepared formulation contained Dihydroartemesinin, curcumin, Groundnut Oil, Cremephor RH, and Tween 80. ...The result …
A new self-micro emulsifying drug delivery system has been developed to improve the solubility of dihydroartemisinin and curcumin …
Enhanced intestinal absorption of curcumin in Caco-2 cell monolayer using mucoadhesive nanostructured lipid carriers.
Chanburee S, Tiyaboonchai W. Chanburee S, et al. J Biomed Mater Res B Appl Biomater. 2018 Feb;106(2):734-741. doi: 10.1002/jbm.b.33884. Epub 2017 Mar 21. J Biomed Mater Res B Appl Biomater. 2018. PMID: 28323388
After lyophilization, all formulations possessed a mean size of <400 nm with a zeta potential of -30 mV and a high entrapment efficacy up to 90%. All NLCs formulation showed significantly improvement in curcumin water solubility, more than 60-folds as compared to …
After lyophilization, all formulations possessed a mean size of <400 nm with a zeta potential of -30 mV and a high entrapment efficacy up …
11 results