Inositol hexaphosphate (IP6) - Search Results

Year	Number of Results
1975	1
1987	1
1988	1
1989	4
1990	3
1991	1
1992	5
1994	3
1995	3
1996	3
1997	2
1998	6
1999	14
2000	9
2001	7
2002	10
2003	11
2004	15
2005	14
2006	18
2007	17
2008	16
2009	14
2010	21
2011	14
2012	26
2013	19
2014	26
2015	22
2016	19
2017	24
2018	14
2019	33
2020	38
2021	30
2022	16
2023	25
2024	3

1

On the Possible Effect of Phytic Acid (Myo-Inositol Hexaphosphoric Acid, IP6) on Cytochromes P450 and Systems of Xenobiotic Metabolism in Different Hepatic Models.

Frybortova V, Satka S, Jourova L, Zapletalova I, Srejber M, Briolotti P, Daujat-Chavanieu M, Gerbal-Chaloin S, Anzenbacher P, Otyepka M, Anzenbacherova E. Frybortova V, et al. Int J Mol Sci. 2024 Mar 23;25(7):3610. doi: 10.3390/ijms25073610. Int J Mol Sci. 2024. PMID: 38612422 Free PMC article.

As compounds of natural origin enter human body, it is necessary to investigate their possible interactions with the metabolism of drugs and xenobiotics in general, namely with the cytochrome P450 (CYP) system. Phytic acid (myo-inositol hexaphosphoric acid …

As compounds of natural origin enter human body, it is necessary to investigate their possible interactions with the metabolism of drugs and …

2

Kinetics of Phosphate Ions and Phytase Activity Production for Lactic Acid-Producing Bacteria Utilizing Milling and Whitening Stages Rice Bran as Biopolymer Substrates.

Nunta R, Khemacheewakul J, Techapun C, Sommanee S, Feng J, Htike SL, Mahakuntha C, Porninta K, Phimolsiripol Y, Jantanasakulwong K, Moukamnerd C, Watanabe M, Kumar A, Leksawasdi N. Nunta R, et al. Biomolecules. 2023 Dec 10;13(12):1770. doi: 10.3390/biom13121770. Biomolecules. 2023. PMID: 38136641 Free PMC article.

A study evaluated nine kinetic data and four kinetic parameters related to growth, production of various phytase activities (PE(act)), and released phosphate ion concentration ([Pi]) from five lactic acid bacteria (LAB) strains cultivated in three types of media: phytate ( …

A study evaluated nine kinetic data and four kinetic parameters related to growth, production of various phytase activities (PE(act)), and r …

3

Inositol hexaphosphate enhances chemotherapy by reversing senescence induced by persistently activated PERK and diphthamide modification of eEF2.

Xu B, Jia Q, Liao X, Fan T, Mou L, Song Y, Zhu C, Yang T, Li Z, Wang M, Zhang Q, Liang L. Xu B, et al. Cancer Lett. 2024 Feb 1;582:216591. doi: 10.1016/j.canlet.2023.216591. Epub 2023 Dec 12. Cancer Lett. 2024. PMID: 38097134

In addition, we screened diverse phytochemicals for ER inhibitors in silico, identifying inositol hexaphosphate (IP6), whose strong binding was confirmed by surface plasmon resonance. Finally, we confirmed the ability of IP6 to reverse colorectal cance …

In addition, we screened diverse phytochemicals for ER inhibitors in silico, identifying inositol hexaphosphate (IP6), …

4

Phytic acid effect on periodontal ligament fibroblast: An in-vitro study.

Aryal A C S, Nassar M, Rani K G A, Al-Rawi AM, Nassar R, Islam MS. Aryal A C S, et al. PLoS One. 2023 Dec 14;18(12):e0295612. doi: 10.1371/journal.pone.0295612. eCollection 2023. PLoS One. 2023. PMID: 38096253 Free PMC article.

OBJECTIVES: This study evaluated phytic acid (IP6) effect on the viability, alkaline phosphatase (ALP) activity and calcium release of human periodontal ligament (HPDL) cells in optimal (OGL) and elevated glucose level (EGL) in cell culture media. ...Meanwhil …

OBJECTIVES: This study evaluated phytic acid (IP6) effect on the viability, alkaline phosphatase (ALP) activity and cal …

5

Monitoring Intracellular IP6 with a Genetically Encoded Fluorescence Biosensor.

Li X, Wei Q, Zhao K, Wang W, Liu B, Li W, Wang J. Li X, et al. ACS Sens. 2023 Dec 22;8(12):4484-4493. doi: 10.1021/acssensors.3c00268. Epub 2023 Nov 21. ACS Sens. 2023. PMID: 38079595

Inositol hexakisphosphate (IP6), a naturally occurring metabolite of inositol with specific functions in different organelles or tissues, participates in numerous physiological processes and plays a key role in mammalian metabolic regulation. ...Thus, HIPSer …

Inositol hexakisphosphate (IP6), a naturally occurring metabolite of inositol with specific functions in different orga …

6

Tolerance mechanism of rice (Oryza sativa L.) seedings towards polycyclic aromatic hydrocarbons toxicity: The activation of SPX-mediated signal transduction to maintain P homeostasis.

Wu J, Liu X, Ge F, Li F, Liu N. Wu J, et al. Environ Pollut. 2024 Jan 15;341:123009. doi: 10.1016/j.envpol.2023.123009. Epub 2023 Nov 23. Environ Pollut. 2024. PMID: 38006996

Results showed that three PAHs significantly activated the phosphoinositide signaling system involving the phosphorus (P) metabolism and homeostasis in rice roots. This activation increased phytic acid (IP(6)) levels to over 54.12% of the control (p < 0.05). ...C

…

Results showed that three PAHs significantly activated the phosphoinositide signaling system involving the phosphorus (P) metabolism and hom …

7

Magnetic ZnFe₂O₄ composite advances SERS assay for Patent blue V.

Qin Y, Tian X, Wang H, Guo X, Wen Y, Yang H. Qin Y, et al. Anal Chim Acta. 2023 Dec 1;1283:341896. doi: 10.1016/j.aca.2023.341896. Epub 2023 Oct 18. Anal Chim Acta. 2023. PMID: 37977770

RESULTS: In this work, we immobilize gold nanoparticles (Au NPs) on the surface of ZnFe(2)O(4) with aid of Inositol hexaphosphate (IP(6)) to prepare a novel magnetic surface-enhanced Raman scattering (SERS) substrate (designated as ZnFe(2)O(4)-IP(6)-Au NPs) for rapi …

RESULTS: In this work, we immobilize gold nanoparticles (Au NPs) on the surface of ZnFe(2)O(4) with aid of Inositol hexaphosphate …

8

Biomimetic Construction of Degradable DNAzyme-Loaded Nanocapsules for Self-Sufficient Gene Therapy of Pulmonary Metastatic Breast Cancer.

Jiang R, Li L, Li M. Jiang R, et al. ACS Nano. 2023 Nov 14;17(21):22129-22144. doi: 10.1021/acsnano.3c09581. Epub 2023 Nov 5. ACS Nano. 2023. PMID: 37925681

Herein, a degradable biomimetic DNAzyme biocapsule is developed with the poly(ethylenimine) (PEI)-DNAzyme complex encapsulated in a Mn(2+)/Zn(2+)-coordinated inositol hexaphosphate (IP6) capsule modified with the cRGD targeting peptide for high-efficiency gen …

Herein, a degradable biomimetic DNAzyme biocapsule is developed with the poly(ethylenimine) (PEI)-DNAzyme complex encapsulated in a Mn(2+)/Z …

9

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.

Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB. Kefala Stavridi A, et al. Nucleic Acids Res. 2023 Nov 27;51(21):11732-11747. doi: 10.1093/nar/gkad863. Nucleic Acids Res. 2023. PMID: 37870477 Free PMC article.

The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals for repairing endogenous, accidental or programmed DNA Double-Strand Breaks. c-NHEJ is regulated by several accessory factors, post-translational modifications, endogenous chemical age …

The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals for repairing endogenous, accidental or prog …

10

Effect of bio-chemical changes due to conventional ageing or chemical soaking on the texture changes of common beans during cooking.

Zhu L, Che AJC, Kyomugasho C, Chen D, Hendrickx M. Zhu L, et al. Food Res Int. 2023 Nov;173(Pt 2):113377. doi: 10.1016/j.foodres.2023.113377. Epub 2023 Aug 18. Food Res Int. 2023. PMID: 37803715

To establish the HTC defect development, the cooking kinetics of seeds of ten bean accessions (belonging to seven common bean market classes), fresh and conventionally aged (35 C, 83% RH, 3 months) were compared to those obtained after soaking in specific salt solutions (in 0.1 M …

To establish the HTC defect development, the cooking kinetics of seeds of ten bean accessions (belonging to seven common bean market classes …

11

Recent advances in iron encapsulation and its application in food fortification.

Dehnad D, Ghorani B, Emadzadeh B, Emadzadeh M, Assadpour E, Rajabzadeh G, Jafari SM. Dehnad D, et al. Crit Rev Food Sci Nutr. 2023 Sep 13:1-17. doi: 10.1080/10408398.2023.2256004. Online ahead of print. Crit Rev Food Sci Nutr. 2023. PMID: 37703437 Review.

Nevertheless, the majority of Fe in flour is available as salts of phytic acid (IP6) and phytates, reducing Fe bioavailability in the human body. The sourdough process degrades IP6 completely while Chorleywood Bread Making Process and conventional proc …

Nevertheless, the majority of Fe in flour is available as salts of phytic acid (IP6) and phytates, reducing Fe bioavail …

12

Phytic Acid: A Novel Dentine Conditioning Agent for Glass Ionomer Cement Restorations: An In Vitro Scanning Electron Microscopic Study.

Souparnika DP, Babu BS, Shetty N, Imteyaz F, Parthiban G, Kumar GV. Souparnika DP, et al. J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S391-S395. doi: 10.4103/jpbs.jpbs_411_22. Epub 2023 Jul 5. J Pharm Bioallied Sci. 2023. PMID: 37654334 Free PMC article.

Each group received the following treatment: group 1 with 10% polyacrylic acid; group 2 with 10% ethylenediaminetetraacetic acid (EDTA); group 3 with 1% phytic acid; and group 4 with no conditioning (control). ...CONCLUSION: The results of the present …

Each group received the following treatment: group 1 with 10% polyacrylic acid; group 2 with 10% ethylenediaminetetraacetic acid …

13

Exploring porcine kidney explants as a model for the study of nephrotoxins and the therapeutic potential of phytic acid.

Suhett WG, Gerez JR, Hohmann MS, Staurengo-Ferrari L, Verri WA, Pinho FHO, de Barros LD, Cardim ST, Flaiban KMC, Bracarense APFRL. Suhett WG, et al. Environ Toxicol Pharmacol. 2023 Sep;102:104241. doi: 10.1016/j.etap.2023.104241. Epub 2023 Aug 9. Environ Toxicol Pharmacol. 2023. PMID: 37562547

Here, we established a gentamicin nephrotoxicity model using pigs` kidney explants and investigated the effect of phytic acid (IP6) against gentamicin- induced nephrotoxicity. A total of 360 kidney explants were divided into control, gentamicin (10 mM), IP …

Here, we established a gentamicin nephrotoxicity model using pigs` kidney explants and investigated the effect of phytic acid …

14

Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy.

Dilworth L, Stennett D, Omoruyi F. Dilworth L, et al. Biomolecules. 2023 Jun 10;13(6):972. doi: 10.3390/biom13060972. Biomolecules. 2023. PMID: 37371552 Free PMC article. Review.

IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. ...IP6 has been shown to have several cellular and molecular activities associated with its potential role in disease prevention. ...

IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. ...IP6 has been shown to have sev …

15

Application of Inositol Hexaphosphate and Inositol in Dental Medicine: An Overview.

Druzijanic A, Kovic M, Roguljic M, Cigic L, Majstorovic M, Vucenik I. Druzijanic A, et al. Biomolecules. 2023 May 31;13(6):913. doi: 10.3390/biom13060913. Biomolecules. 2023. PMID: 37371493 Free PMC article. Review.

Phosphorylated inositol hexaphosphate (IP6) is a naturally occurring carbohydrate, and its parent compound, myoinositol (Ins), is abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate essentia …

Phosphorylated inositol hexaphosphate (IP6) is a naturally occurring carbohydrate, and its parent compound, myoinositol …

16

The Effect of Inositol Hexakisphosphate on HIV-1 Particle Production and Infectivity can be Modulated by Mutations that Affect the Stability of the Immature Gag Lattice.

Kleinpeter AB, Zhu Y, Mallery DL, Ablan SD, Chen L, Hardenbrook N, Saiardi A, James LC, Zhang P, Freed EO. Kleinpeter AB, et al. J Mol Biol. 2023 Jun 1;435(11):168037. doi: 10.1016/j.jmb.2023.168037. Epub 2023 Jun 16. J Mol Biol. 2023. PMID: 37330292

Thus, depletion of IP6 in virus-producer cells markedly increases M4L/T8I CA-SP1 processing and infectivity. We also show that the introduction of the M4L/T8I mutations partially rescues the assembly and infectivity defects induced by IP6 depletion on WT virions, li …

Thus, depletion of IP6 in virus-producer cells markedly increases M4L/T8I CA-SP1 processing and infectivity. We also show that the in …

17

The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7.

Han Y, Lan T, Ma X, Yang N, Wang C, Xu Z, Chen Z, Tao M, Li H, Wang H, Song Y. Han Y, et al. Biol Pharm Bull. 2023 Aug 1;46(8):1145-1151. doi: 10.1248/bpb.b23-00080. Epub 2023 Jun 8. Biol Pharm Bull. 2023. PMID: 37286513 Free article.

Inositol hexaphosphate (IP6), a widely found natural bioactive substance in grains, effectively inhibits the progression of colorectal cancer (CRC) when used in combination with inositol (INS). ...The effect of IP6 and INS was stronger compared …

Inositol hexaphosphate (IP6), a widely found natural bioactive substance in grains, effectively inhibits the progressio …

18

Phytic Acid Demonstrates Rapid Antibiofilm Activity and Inhibits Biofilm Formation When Used as a Surface Conditioning Agent.

Nassar R, Nassar M, Senok A, Williams D. Nassar R, et al. Microbiol Spectr. 2023 Jun 15;11(3):e0026723. doi: 10.1128/spectrum.00267-23. Epub 2023 May 16. Microbiol Spectr. 2023. PMID: 37191582 Free PMC article.

The aim of this study was to evaluate the in vitro antibiofilm properties of phytic acid (IP6), which is a potential alternative treatment agent. ...The findings of this study identified a novel use of phytic acid as a potential antibiofilm agen …

The aim of this study was to evaluate the in vitro antibiofilm properties of phytic acid (IP6), which is a potential al …

19

Effect of different chelating agents on the shear bond strength of calcium silicate-based cements to coronal dentin.

Elsayed MA, Islam MS, Elbeltagy K, Nassar M. Elsayed MA, et al. Aust Endod J. 2023 Sep;49 Suppl 1:426-432. doi: 10.1111/aej.12759. Epub 2023 Apr 24. Aust Endod J. 2023. PMID: 37092561

We evaluated the shear bond strength (SBS) of mineral trioxide aggregate (MTA) and Biodentine (BD) to coronal dentin after treatment with ethylenediaminetetraacetic acid (EDTA), phytic acid (IP6), or etidronic acid (HEDP). Sodium hypochlorite-tr …

We evaluated the shear bond strength (SBS) of mineral trioxide aggregate (MTA) and Biodentine (BD) to coronal dentin after treatment with et …

20

Crosslinked and PEGylated Pectin Chitosan nanoparticles for delivery of Phytic acid to colon.

Mishra N, Pal S, Sharma M, Nisha R, Raj Pal R, Singh P, Singh S, Maurya P, Singh N, Alka, Ranjan Mishra P, Saraf SA. Mishra N, et al. Int J Pharm. 2023 May 25;639:122937. doi: 10.1016/j.ijpharm.2023.122937. Epub 2023 Apr 15. Int J Pharm. 2023. PMID: 37068717

This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two sets of PEGylated NPs to deliver phytic acid (IP6) to colon orally as it has potential to manage colon cancer but fails …

This study employed blending-crosslinking of polymers (PN&CN) followed by emulsification-solvent evaporation to prepare and compare two …

21

Enrich and switch: IP6 and maturation of HIV-1 capsid.

Wu C, Xiong Y. Wu C, et al. Nat Struct Mol Biol. 2023 Mar;30(3):239-241. doi: 10.1038/s41594-023-00940-w. Nat Struct Mol Biol. 2023. PMID: 36849641 Free PMC article.

Recent studies offer new insight on the mechanisms of IP6-mediated HIV-1 capsid assembly. The immature Gag lattice enables enrichment of IP6 into virions, aiding capsid maturation. ...

Recent studies offer new insight on the mechanisms of IP6-mediated HIV-1 capsid assembly. The immature Gag lattice enables enrichment …

22

The Contribution of Phytate-Degrading Enzymes to Chicken-Meat Production.

Selle PH, Macelline SP, Chrystal PV, Liu SY. Selle PH, et al. Animals (Basel). 2023 Feb 9;13(4):603. doi: 10.3390/ani13040603. Animals (Basel). 2023. PMID: 36830391 Free PMC article. Review.

This was amplified by an expanding appreciation of the powerful anti-nutritive properties of the substrate, phytate (myo-inositol hexaphosphate; IP(6)), which is invariably present in all plant-sourced feedstuffs and practical broiler diets. ...The liberation of phy …

This was amplified by an expanding appreciation of the powerful anti-nutritive properties of the substrate, phytate (myo-inositol …

23

Inositol hexaphosphate promotes intestinal adaptation in short bowel syndrome via an HDAC3-mediated epigenetic pathway.

Wang W, Wang Y, Lu Y, Tian X, Chen S, Wu B, Du J, Xiao Y, Cai W. Wang W, et al. Food Nutr Res. 2023 Feb 2;67. doi: 10.29219/fnr.v67.8694. eCollection 2023. Food Nutr Res. 2023. PMID: 36794012 Free PMC article.

BACKGROUND: Short bowel syndrome (SBS) has high morbidity and mortality rates, and promoting intestinal adaptation of the residual intestine is a critical treatment. Dietary inositol hexaphosphate (IP6) plays an important role in maintaining intestinal homeos …

BACKGROUND: Short bowel syndrome (SBS) has high morbidity and mortality rates, and promoting intestinal adaptation of the residual intestine …

24

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP(7) metabolism in the enteric nervous system.

Ito M, Fujii N, Kohara S, Hori S, Tanaka M, Wittwer C, Kikuchi K, Iijima T, Kakimoto Y, Hirabayashi K, Kurotaki D, Jessen HJ, Saiardi A, Nagata E. Ito M, et al. J Biol Chem. 2023 Mar;299(3):102928. doi: 10.1016/j.jbc.2023.102928. Epub 2023 Jan 19. J Biol Chem. 2023. PMID: 36681123 Free PMC article.

Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled inositol pyrophosphate levels in mammalian organs using an originally designed …

Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue …

25

HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly.

Renner N, Kleinpeter A, Mallery DL, Albecka A, Rifat Faysal KM, Böcking T, Saiardi A, Freed EO, James LC. Renner N, et al. Nat Struct Mol Biol. 2023 Mar;30(3):370-382. doi: 10.1038/s41594-022-00887-4. Epub 2023 Jan 9. Nat Struct Mol Biol. 2023. PMID: 36624347 Free PMC article.

Here we show that the immature lattice is required to concentrate the cellular metabolite inositol hexakisphosphate (IP6) into virions to catalyze mature capsid assembly. ...IP6 cannot be replaced by other inositol phosphate (IP) molecules, as substitu …

Here we show that the immature lattice is required to concentrate the cellular metabolite inositol hexakisphosphate (IP6) into …

26

Effect of phytic acid on dentinal collagen solubilization and its binding and debinding potentials to dentin.

Forgione D, Nassar M, Seseogullari-Dirihan R, Jamleh A, Tezvergil-Mutluay A. Forgione D, et al. J Dent. 2023 Jan;128:104361. doi: 10.1016/j.jdent.2022.104361. Epub 2022 Nov 13. J Dent. 2023. PMID: 36379300

OBJECTIVES: To study phytic acid (IP6) effect on collagen solubilization by assessing hydroxyproline (HYP) release, evaluate its binding to demineralized (DD) and mineralized dentin (MD) and determine the effect of different media on debinding of IP6. …

OBJECTIVES: To study phytic acid (IP6) effect on collagen solubilization by assessing hydroxyproline (HYP) release, eva …

27

Effect of phytic acid on bond strength and interfacial integrity of universal adhesive to deep dentin.

Attia AM, Abo-Elezz AF, Safy RK. Attia AM, et al. Braz Dent J. 2022 Sep-Oct;33(5):116-125. doi: 10.1590/0103-6440202204810. Braz Dent J. 2022. PMID: 36287493 Free PMC article.

This study investigated the effect of phytic acid (IP6) in different concentrations and application times on microtensile bond strength (TBS) and interfacial integrity of universal adhesive to deep dentin. Flat deep dentin surfaces of 48 human molars were eit …

This study investigated the effect of phytic acid (IP6) in different concentrations and application times on microtensi …

28

Effects of limestone solubility on the efficacy of a novel consensus bacterial 6-phytase variant to improve mineral digestibility, retention, and bone ash in young broilers fed low-calcium diets containing no added inorganic phosphate.

Bello A, Kwakernaak C, Dersjant-Li Y. Bello A, et al. J Anim Sci. 2022 Dec 1;100(12):skac337. doi: 10.1093/jas/skac337. J Anim Sci. 2022. PMID: 36239636 Free PMC article.

Fecal samples collected on days 18 to 20 and ileal digesta collected on day 21 were analyzed for titanium dioxide, Ca, P, and phytate (IP6, inositol hexakisphosphate). Tibias (day 21) were analyzed for ash content. ...Increasing dose levels of PhyG resulted in an ex …

Fecal samples collected on days 18 to 20 and ileal digesta collected on day 21 were analyzed for titanium dioxide, Ca, P, and phytate (IP …

29

Inositol hexakisphosphate is required for Integrator function.

Lin MH, Jensen MK, Elrod ND, Huang KL, Welle KA, Wagner EJ, Tong L. Lin MH, et al. Nat Commun. 2022 Sep 30;13(1):5742. doi: 10.1038/s41467-022-33506-3. Nat Commun. 2022. PMID: 36180473 Free PMC article.

Here we report a cryo-EM structure of the Drosophila ICM, at 2.74 A resolution, revealing stable association of an inositol hexakisphosphate (IP(6)) molecule. The IP(6) binding site is located in a highly electropositive pocket at an interface among all three subunits of I …

Here we report a cryo-EM structure of the Drosophila ICM, at 2.74 A resolution, revealing stable association of an inositol hexakisph …

30

Mutation of GmIPK1 Gene Using CRISPR/Cas9 Reduced Phytic Acid Content in Soybean Seeds.

Song JH, Shin G, Kim HJ, Lee SB, Moon JY, Jeong JC, Choi HK, Kim IA, Song HJ, Kim CY, Chung YS. Song JH, et al. Int J Mol Sci. 2022 Sep 13;23(18):10583. doi: 10.3390/ijms231810583. Int J Mol Sci. 2022. PMID: 36142495 Free PMC article.

Phytic acid (PA) acts as an antinutrient substance in cereal grains, disturbing the bioavailability of micronutrients, such as iron and zinc, in humans, causing malnutrition. GmIPK1 encodes the inositol 1,3,4,5,6-pentakisphosphate 2-kinase enzyme, which conve …

Phytic acid (PA) acts as an antinutrient substance in cereal grains, disturbing the bioavailability of micronutrients, such as …

31

IP6 reduces colorectal cancer metastasis by mediating the interaction of gut microbiota with host genes.

Lan TT, Song Y, Liu XH, Liu CP, Zhao HC, Han YS, Wang CH, Yang N, Xu Z, Tao M, Li H. Lan TT, et al. Front Nutr. 2022 Sep 2;9:979135. doi: 10.3389/fnut.2022.979135. eCollection 2022. Front Nutr. 2022. PMID: 36118769 Free PMC article.

Inositol hexaphosphate (IP6) is a phytochemical widely found in grains and legumes that plays an anti-cancer role. ...The beta diversity partly tended to return to the normal level after IP6 intervention. Especially, Lactobacillus helveticus and Lactoc …

Inositol hexaphosphate (IP6) is a phytochemical widely found in grains and legumes that plays an anti-cancer role. ...T …

32

Stage-Specific Effect of Inositol Hexaphosphate on Cancer Stem Cell Pool during Growth and Progression of Prostate Tumorigenesis in TRAMP Model.

Raina K, Kandhari K, Jain AK, Ravichandran K, Maroni P, Agarwal C, Agarwal R. Raina K, et al. Cancers (Basel). 2022 Aug 30;14(17):4204. doi: 10.3390/cancers14174204. Cancers (Basel). 2022. PMID: 36077751 Free PMC article.

Herein, we assessed the stage-specific efficacy of inositol hexaphosphate (IP6, phytic acid), a bioactive food component, on prostate cancer (PCa) growth and progression in a transgenic mouse model of prostate cancer (TRAMP). Starting at 4, 12, …

Herein, we assessed the stage-specific efficacy of inositol hexaphosphate (IP6, phytic acid), a bioactive …

33

Apparent digestibility of energy and nutrients and efficiency of microbial phytase is influenced by body weight of pigs.

Lagos LV, Bedford MR, Stein HH. Lagos LV, et al. J Anim Sci. 2022 Oct 1;100(10):skac269. doi: 10.1093/jas/skac269. J Anim Sci. 2022. PMID: 35980766 Free PMC article.

The ATTD of GE, K, and Mg increased (linear and quadratic; P < 0.05), but ATTD of Ca and Na (linear; P < 0.05) and of P (linear and quadratic; P < 0.05) decreased as pig BW increased. Ileal IP6 and IP3 (linear and quadratic; P < 0.05) and ileal IP5 and IP4 (lin

…

The ATTD of GE, K, and Mg increased (linear and quadratic; P < 0.05), but ATTD of Ca and Na (linear; P < 0.05) and of P (linear and qu

…

34

Evaluation of High Doses of Phytase in a Low-Phosphorus Diet in Comparison to a Phytate-Free Diet on Performance, Apparent Ileal Digestibility of Nutrients, Bone Mineralization, Intestinal Morphology, and Immune Traits in 21-Day-Old Broiler Chickens.

Martínez-Vallespín B, Männer K, Ader P, Zentek J. Martínez-Vallespín B, et al. Animals (Basel). 2022 Aug 2;12(15):1955. doi: 10.3390/ani12151955. Animals (Basel). 2022. PMID: 35953944 Free PMC article.

The supplementation of feed with phytases enables broilers to utilize more efficiently phosphorus (P) from phytic acid (IP6), the main storage form of P in plants. The current study evaluated the addition of 500, 1000, and 3000 FTU of phytase per kg to a phyt …

The supplementation of feed with phytases enables broilers to utilize more efficiently phosphorus (P) from phytic acid (IP6 …

35

Biodegradable Amorphous Copper Iron Tellurite Promoting the Utilization of Fenton-Like Ions for Efficient Synergistic Cancer Theranostics.

Liu H, Jiang R, Lu Y, Shan B, Wen Y, Li M. Liu H, et al. ACS Appl Mater Interfaces. 2022 Jun 29;14(25):28537-28547. doi: 10.1021/acsami.2c03975. Epub 2022 Jun 15. ACS Appl Mater Interfaces. 2022. PMID: 35704874

The major hurdles of chemodynamic therapy (CDT) are nondegradability and low-efficiency utilization of chemodynamic agents, and intracellular glutathione (GSH)-induced rapid scavenging of hydroxyl radicals (OH). Here, a biodegradable a-CFT@IP6@BSA agent is reported for eff …

The major hurdles of chemodynamic therapy (CDT) are nondegradability and low-efficiency utilization of chemodynamic agents, and intracellula …

36

Uranium chelating ability of decorporation agents in serum evaluated by X-ray absorption spectroscopy.

Uehara A, Matsumura D, Tsuji T, Yakumaru H, Tanaka I, Shiro A, Saitoh H, Ishihara H, Homma-Takeda S. Uehara A, et al. Anal Methods. 2022 Jun 23;14(24):2439-2445. doi: 10.1039/d2ay00565d. Anal Methods. 2022. PMID: 35694955

The chelating agents used were 1-hydroxyethane 1,1-bisphosphonate (EHBP), inositol hexaphosphate (IP6), deferoxamine B (DFO), and diethylenetriaminepentaacetate (DTPA). ...The main ligands forming complexes with uranium in the serum were estimated as follows: …

The chelating agents used were 1-hydroxyethane 1,1-bisphosphonate (EHBP), inositol hexaphosphate (IP6), deferoxamine B …

37

Inositol Hexakisphosphate (IP6) Accelerates Immature HIV-1 Gag Protein Assembly toward Kinetically Trapped Morphologies.

Pak AJ, Gupta M, Yeager M, Voth GA. Pak AJ, et al. J Am Chem Soc. 2022 Jun 15;144(23):10417-10428. doi: 10.1021/jacs.2c02568. Epub 2022 Jun 6. J Am Chem Soc. 2022. PMID: 35666943 Free PMC article.

To date, however, several distinct mechanistic roles for IP6 have been proposed on the basis of independent functional, structural, and kinetic studies. ...Our analysis identifies IP6 as an assembly accelerant that promotes curvature generation and fissure-like defe …

To date, however, several distinct mechanistic roles for IP6 have been proposed on the basis of independent functional, structural, a …

38

Calcium transport and phytate hydrolysis during chemical hardening of common bean seeds.

Zhu L, Mukherjee A, Kyomugasho C, Chen D, Hendrickx M. Zhu L, et al. Food Res Int. 2022 Jun;156:111315. doi: 10.1016/j.foodres.2022.111315. Epub 2022 Apr 30. Food Res Int. 2022. PMID: 35651071

The Ca(2+) concentrations in the whole beans and cotyledons of beans soaked and cooked in CaCl(2) solutions significantly increased while inositol hexaphosphate IP(6) content showed no significant changes. ...

The Ca(2+) concentrations in the whole beans and cotyledons of beans soaked and cooked in CaCl(2) solutions significantly increased while …

39

Development of LC-MS-ESI-TOF method for quantification of phytates in food using ¹³C-labelled maize as internal standard.

Tanilas K, Kriščiunaite T. Tanilas K, et al. Anal Bioanal Chem. 2022 Feb;414(4):1539-1552. doi: 10.1007/s00216-021-03770-1. Epub 2022 Jan 13. Anal Bioanal Chem. 2022. PMID: 35024913

The effectiveness of liberating IP1, IP2, IP3, IP4, and IP5 from phytic acid extracted form U-(13)C-labelled maize was evaluated for a variety of hydrolysis conditions, including enzymatic and acid hydrolysis. Enzymatic degradation of phytic acid …

The effectiveness of liberating IP1, IP2, IP3, IP4, and IP5 from phytic acid extracted form U-(13)C-labelled maize was evaluat …

40

Inositol Phosphates and Retroviral Assembly: A Cellular Perspective.

Ricaña CL, Dick RA. Ricaña CL, et al. Viruses. 2021 Dec 15;13(12):2516. doi: 10.3390/v13122516. Viruses. 2021. PMID: 34960784 Free PMC article. Review.

Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retro …

Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol …

41

Effect of smear layer removal agents on the microhardness and roughness of radicular dentin.

Muana HL, Nassar M, Dargham A, Hiraishi N, Tagami J. Muana HL, et al. Saudi Dent J. 2021 Nov;33(7):661-665. doi: 10.1016/j.sdentj.2020.05.001. Epub 2020 May 29. Saudi Dent J. 2021. PMID: 34803316 Free PMC article.

PURPOSE: To evaluate the effect of phytic acid (IP6) on the surface roughness and microhardness of human root canal dentin and compare it to other smear layer removal agents. ...The specimens were polished and then randomly divided into five groups (n = 20) a …

PURPOSE: To evaluate the effect of phytic acid (IP6) on the surface roughness and microhardness of human root canal den …

42

The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis.

Desfougères Y, Portela-Torres P, Qiu D, Livermore TM, Harmel RK, Borghi F, Jessen HJ, Fiedler D, Saiardi A. Desfougères Y, et al. Adv Biol Regul. 2022 Jan;83:100835. doi: 10.1016/j.jbior.2021.100835. Epub 2021 Nov 10. Adv Biol Regul. 2022. PMID: 34782304 Free PMC article.

Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP(6) also known as Phytic acid) present in the amoeba allowed the discovery of the more …

Initial studies on the inositol phosphates metabolism were enabled by the social amoeba Dictyostelium discoideum. The abundant amount …

43

Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics.

Nassar R, Nassar M, Vianna ME, Naidoo N, Alqutami F, Kaklamanos EG, Senok A, Williams D. Nassar R, et al. Front Cell Infect Microbiol. 2021 Oct 26;11:753649. doi: 10.3389/fcimb.2021.753649. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34765567 Free PMC article.

BACKGROUND: Phytic acid (IP6) is a promising and emerging agent, and because of its unique structure and distinctive properties, it lends itself to several applications in dentistry. ...RESULTS: IP6 was biocidal against all tested microorganisms. At co …

BACKGROUND: Phytic acid (IP6) is a promising and emerging agent, and because of its unique structure and distinctive pr …

44

Effect of increasing dose level of a novel consensus bacterial 6-phytase variant on phytate degradation in broilers fed diets containing varied phytate levels.

Dersjant-Li Y, Christensen T, Knudsen S, Bello A, Toghyani M, Liu SY, Selle PH, Marchal L. Dersjant-Li Y, et al. Br Poult Sci. 2022 Jun;63(3):395-405. doi: 10.1080/00071668.2021.2000586. Epub 2022 Jan 19. Br Poult Sci. 2022. PMID: 34739328

The effect of increasing the dose level of a novel consensus bacterial 6-phytase variant on apparent ileal digestibility (AID) of phosphorus (P), phytic acid (inositol hexa-phosphate, IP(6)) and ileal IP(6) degradation profile was studied in diets containing …

The effect of increasing the dose level of a novel consensus bacterial 6-phytase variant on apparent ileal digestibility (AID) of phosphorus …

45

Preservation of HIV-1 Gag Helical Bundle Symmetry by Bevirimat Is Central to Maturation Inhibition.

Pak AJ, Purdy MD, Yeager M, Voth GA. Pak AJ, et al. J Am Chem Soc. 2021 Nov 17;143(45):19137-19148. doi: 10.1021/jacs.1c08922. Epub 2021 Nov 5. J Am Chem Soc. 2021. PMID: 34739240 Free PMC article.

Here, we employed extensive molecular dynamics (MD) simulations and free energy calculations to quantitatively investigate molecular structure-activity relationships, comparing wild-type and mutant viruses in the presence and absence of BVM and inositol hexakisphosphate ( …

Here, we employed extensive molecular dynamics (MD) simulations and free energy calculations to quantitatively investigate molecular structu …

46

HIV-1 CA Inhibitors Are Antagonized by Inositol Phosphate Stabilization of the Viral Capsid in Cells.

Sowd GA, Shi J, Aiken C. Sowd GA, et al. J Virol. 2021 Nov 23;95(24):e0144521. doi: 10.1128/JVI.01445-21. Epub 2021 Oct 6. J Virol. 2021. PMID: 34613803 Free PMC article.

Capsid stability is mediated in vitro by binding to the host cell metabolite inositol hexakisphosphate (IP6). IP6 depletion in target cells has little effect on HIV-1 infection. ...Capsid inhibitors block HIV-1 infection at multiple steps, offering advantages …

Capsid stability is mediated in vitro by binding to the host cell metabolite inositol hexakisphosphate (IP6). IP6 deple …

47

A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.

Obr M, Schur FKM, Dick RA. Obr M, et al. Viruses. 2021 Sep 17;13(9):1853. doi: 10.3390/v13091853. Viruses. 2021. PMID: 34578434 Free PMC article. Review.

The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles. ...Here, we discuss the different steps in the viral life cycle that are influenced by IP6, …

The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of H …

48

Vancomycin Hydrochloride Loaded Hydroxyapatite Mesoporous Microspheres with Micro/Nano Surface Structure to Increase Osteogenic Differentiation and Antibacterial Ability.

Zhang B, Chai Y, Huang K, Wei X, Mei Z, Wu X, Dai H. Zhang B, et al. J Biomed Nanotechnol. 2021 Aug 1;17(8):1668-1678. doi: 10.1166/jbn.2021.3128. J Biomed Nanotechnol. 2021. PMID: 34544543

In this study, vancomycin hydrochloride-loaded mesoporous hydroxyapatite microspheres with micro/nanosurface structures were synthesized to increase osteogenic differentiation and antibacterial ability. Phytic acid (IP6) was used as a template to prepare meso …

In this study, vancomycin hydrochloride-loaded mesoporous hydroxyapatite microspheres with micro/nanosurface structures were synthesized to …

49

Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-beta-catenin-ABCG1 signaling pathway.

Liao X, Zhang Y, Xu B, Ali A, Liu X, Jia Q. Liao X, et al. J Cancer. 2021 Aug 24;12(20):6071-6080. doi: 10.7150/jca.62141. eCollection 2021. J Cancer. 2021. PMID: 34539880 Free PMC article.

Oxaliplatin, a platinum-based chemotherapy drug, has limited efficacy in treating HCC, characterized by intrinsic and acquired resistance. Inositol hexaphosphate (IP6), a carbohydrate abundant in grains, has contributed to the rising popularity of whole grain …

Oxaliplatin, a platinum-based chemotherapy drug, has limited efficacy in treating HCC, characterized by intrinsic and acquired resistance. …

50

Derivation and characterization of an HIV-1 mutant that rescues IP₆ binding deficiency.

Poston D, Zang T, Bieniasz P. Poston D, et al. Retrovirology. 2021 Aug 28;18(1):25. doi: 10.1186/s12977-021-00571-3. Retrovirology. 2021. PMID: 34454514 Free PMC article.

Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP(6)), which is proposed to stabilize both the immature Gag lattice and the mature capsid lattice by binding to rings of primary amines at the center of Gag or capsid p …

Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP(6)), which is proposed to …

51

Understanding the Protective Effect of Phytate in Bone Decalcification Related-Diseases.

Sanchis P, López-González ÁA, Costa-Bauzá A, Busquets-Cortés C, Riutord P, Calvo P, Grases F. Sanchis P, et al. Nutrients. 2021 Aug 20;13(8):2859. doi: 10.3390/nu13082859. Nutrients. 2021. PMID: 34445019 Free PMC article.

Myo-inositol hexaphosphate (phytate; IP6) is a natural compound that is abundant in cereals, legumes, and nuts, and it can bind to crystal surfaces and disturb crystal development, acting as crystallization inhibitor. ...This led us to perform a cross-section …

Myo-inositol hexaphosphate (phytate; IP6) is a natural compound that is abundant in cereals, legumes, and nuts, and it …

52

Effects of Inositol Hexaphosphate and Myo-Inositol Administration in Breast Cancer Patients during Adjuvant Chemotherapy.

Amabile MI, De Luca A, Tripodi D, D'Alberti E, Melcarne R, Imbimbo G, Picconi O, D'Andrea V, Vergine M, Sorrenti S, Molfino A. Amabile MI, et al. J Pers Med. 2021 Jul 30;11(8):756. doi: 10.3390/jpm11080756. J Pers Med. 2021. PMID: 34442400 Free PMC article.

BACKGROUND: Treatment of breast cancer (BC) includes locoregional and systemic therapies depending on tumor and patient's characteristics. Inositol hexaphosphate (IP6) is known as a strong antioxidant agent, able to improve local (i.e., breast region) side ef …

BACKGROUND: Treatment of breast cancer (BC) includes locoregional and systemic therapies depending on tumor and patient's characteristics. …

53

Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways.

Wee Y, Yang CH, Chen SK, Yen YC, Wang CS. Wee Y, et al. Food Sci Nutr. 2021 Apr 10;9(6):3240-3249. doi: 10.1002/fsn3.2286. eCollection 2021 Jun. Food Sci Nutr. 2021. PMID: 34136188 Free PMC article.

Inositol hexaphosphate (IP6) is a dietary compound commonly obtained from corn, rice, etc. ...Interestingly, our data suggested that IP6 polarizes bone marrow-derived macrophages (BMDM) into an M2a-like subtype. ...

Inositol hexaphosphate (IP6) is a dietary compound commonly obtained from corn, rice, etc. ...Interestingly, our data s …

54

Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer.

Obr M, Ricana CL, Nikulin N, Feathers JR, Klanschnig M, Thader A, Johnson MC, Vogt VM, Schur FKM, Dick RA. Obr M, et al. Nat Commun. 2021 May 28;12(1):3226. doi: 10.1038/s41467-021-23506-0. Nat Commun. 2021. PMID: 34050170 Free PMC article.

Inositol hexakisphosphate (IP6) is an assembly cofactor for HIV-1. ...IP6 is ~100-fold more potent at promoting RSV mature capsid protein (CA) assembly than observed for HIV-1 and removal of IP6 in cells reduces infectivity by 100-fold. ...

Inositol hexakisphosphate (IP6) is an assembly cofactor for HIV-1. ...IP6 is ~100-fold more potent at promoting RSV mat …

55

Molecular mechanism of N-terminal acetylation by the ternary NatC complex.

Deng S, Gottlieb L, Pan B, Supplee J, Wei X, Petersson EJ, Marmorstein R. Deng S, et al. Structure. 2021 Oct 7;29(10):1094-1104.e4. doi: 10.1016/j.str.2021.05.003. Epub 2021 May 20. Structure. 2021. PMID: 34019809 Free PMC article.

Here, we report the cryoelectron microscopy structure of S. pombe NatC with a NatE/C-type bisubstrate analog and inositol hexaphosphate (IP(6)), and associated biochemistry studies. ...

Here, we report the cryoelectron microscopy structure of S. pombe NatC with a NatE/C-type bisubstrate analog and inositol hexaphos …

56

Reevaluation of Phytase Action Mechanism in Animal Nutrition.

Kryukov VS, Glebova IV, Zinoviev SV. Kryukov VS, et al. Biochemistry (Mosc). 2021 Jan;86(Suppl 1):S152-S165. doi: 10.1134/S000629792114011X. Biochemistry (Mosc). 2021. PMID: 33827406 Review.

The inhibition of dephosphorylation initiation is not associated with the action mechanism of the enzyme and can be rather due to the insufficient phytase activity or low availability of phytates. The analysis of the transformations in the inositol hexakisphosphate (IP(6)) …

The inhibition of dephosphorylation initiation is not associated with the action mechanism of the enzyme and can be rather due to the insuff …

57

Effect of two phytases at two doses on performance and phytate degradation in broilers during 1-21 days of age.

Dersjant-Li Y, Davin R, Christensen T, Kwakernaak C. Dersjant-Li Y, et al. PLoS One. 2021 Mar 25;16(3):e0247420. doi: 10.1371/journal.pone.0247420. eCollection 2021. PLoS One. 2021. PMID: 33765064 Free PMC article.

Digestibility of Ca did not differ among phytase treatments but at 1,000 FTU/kg AID P was greater with Phy B than Phy C (72.3% vs. 62.7%, P < 0.05). Ileal phytate (myo-inositol hexakisphosphate, IP6) digestibility was greatest with Phy B at 1,000 FTU/kg which was

…

Digestibility of Ca did not differ among phytase treatments but at 1,000 FTU/kg AID P was greater with Phy B than Phy C (72.3% vs. 62.7%, P …

58

In-silico structural analysis of Pseudomonas syringae effector HopZ3 reveals ligand binding activity and virulence function.

Chakraborty J. Chakraborty J. J Plant Res. 2021 May;134(3):599-611. doi: 10.1007/s10265-021-01274-8. Epub 2021 Mar 17. J Plant Res. 2021. PMID: 33730245

AcCoA interactions to substrate binding pocket was transient and dissipated upon in-silico mutation of Ser 279 residue whereas, attachment to catalytic site was found to be stable in the presence of inositol hexaphosphate (IP6) as a co-factor. Interface atoms …

AcCoA interactions to substrate binding pocket was transient and dissipated upon in-silico mutation of Ser 279 residue whereas, attachment t …

59

Snx4-assisted vacuolar targeting of transcription factors defines a new autophagy pathway for controlling ATG expression.

Hanley SE, Willis SD, Cooper KF. Hanley SE, et al. Autophagy. 2021 Nov;17(11):3547-3565. doi: 10.1080/15548627.2021.1877934. Epub 2021 Mar 8. Autophagy. 2021. PMID: 33678121 Free PMC article.

It is physiologically relevant as this Snx4-assisted vacuolar targeting pathway permits cells to fine-tune the autophagic response by controlling the turnover of both positive and negative regulators of ATG transcription.Abbreviations: AIM: Atg8 interacting motif; ATG: autophagy- …

It is physiologically relevant as this Snx4-assisted vacuolar targeting pathway permits cells to fine-tune the autophagic response by contro …

60

Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

Jeong BC, Bae SJ, Ni L, Zhang X, Bai XC, Luo X. Jeong BC, et al. Nat Struct Mol Biol. 2021 Mar;28(3):290-299. doi: 10.1038/s41594-021-00564-y. Epub 2021 Feb 25. Nat Struct Mol Biol. 2021. PMID: 33633399 Free PMC article.

The STRN3 coiled-coil domains form an elongated homotetrameric scaffold that links the complex together. An inositol hexakisphosphate (IP(6)) is identified as a structural cofactor of STRIP1. ...

The STRN3 coiled-coil domains form an elongated homotetrameric scaffold that links the complex together. An inositol hexakisphosphate …

61

Contrasting the effects of phytase and pure myo-inositol on the performance, digestibility, blood and egg yolk inositol levels and digestion physiology of laying hens.

Herwig E, Walk CL, Bedford M, Schwean-Lardner K, Classen HL. Herwig E, et al. Br Poult Sci. 2021 Aug;62(4):517-527. doi: 10.1080/00071668.2021.1894323. Epub 2021 Mar 10. Br Poult Sci. 2021. PMID: 33612025

Laying hen production, inositol concentrations, digestive tract morphology, amino acid digestibility and intestinal inositol transporters transcript abundance were evaluated. ...In conclusion, no effect of phytase or inositol was found for laying hen p …

Laying hen production, inositol concentrations, digestive tract morphology, amino acid digestibility and intestinal inosito …

62

Effect of Natural and Artificial Dentin Conditioners on the Release of Vascular Endothelial Growth Factor.

Khan JA, Hasan A, Dossa S, Ali B. Khan JA, et al. J Endod. 2021 May;47(5):800-805. doi: 10.1016/j.joen.2021.02.001. Epub 2021 Feb 11. J Endod. 2021. PMID: 33581196

INTRODUCTION: The purpose of this study was to observe the release of vascular endothelial growth factor (VEGF) after conditioning with etidronic acid (also known as 1-hydroxyethylidene-1 and 1-bisphosphonate [HEDP]) and phytic acid (inositol hexakisph …

INTRODUCTION: The purpose of this study was to observe the release of vascular endothelial growth factor (VEGF) after conditioning with etid …

63

Phytic acid and its interactions: Contributions to protein functionality, food processing, and safety.

Wang R, Guo S. Wang R, et al. Compr Rev Food Sci Food Saf. 2021 Mar;20(2):2081-2105. doi: 10.1111/1541-4337.12714. Epub 2021 Feb 8. Compr Rev Food Sci Food Saf. 2021. PMID: 33559386 Review.

Is phytic acid (IP6) an undesirable constituent for vegetables and foods? This question is getting harder to answer. Phytic acid contributes to mineral/protein deficiency, but also brings about potential physiological benefits. ...

Is phytic acid (IP6) an undesirable constituent for vegetables and foods? This question is getting harder to answer. …

64

A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly.

Renner N, Mallery DL, Faysal KMR, Peng W, Jacques DA, Böcking T, James LC. Renner N, et al. PLoS Pathog. 2021 Feb 1;17(2):e1009164. doi: 10.1371/journal.ppat.1009164. eCollection 2021 Feb. PLoS Pathog. 2021. PMID: 33524070 Free PMC article.

The clustering of charges required for dNTP import is strongly destabilising and it is proposed that HIV uses the metabolite IP6 to coordinate the pore during assembly. Here we have investigated the role of inositol phosphates in coordinating a ring of positively ch …

The clustering of charges required for dNTP import is strongly destabilising and it is proposed that HIV uses the metabolite IP6 to c …

65

Effect of Small Polyanions on In Vitro Assembly of Selected Members of Alpha-, Beta- and Gammaretroviruses.

Dostálková A, Vokatá B, Kaufman F, Ulbrich P, Ruml T, Rumlová M. Dostálková A, et al. Viruses. 2021 Jan 18;13(1):129. doi: 10.3390/v13010129. Viruses. 2021. PMID: 33477490 Free PMC article.

The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small molecules. A small, negatively charged polyanionic molecule, myo-inositol hexaphosphate (IP6), was identified to stimulate …

The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small mol …

66

Partial characterization and purification of phytase from Lactobacillus plantarum CRL1964 isolated from pseudocereals.

Sandez Penidez SH, Velasco Manini MA, Gerez CL, Rollán GC. Sandez Penidez SH, et al. J Basic Microbiol. 2020 Sep;60(9):787-798. doi: 10.1002/jobm.202000236. Epub 2020 Jul 20. J Basic Microbiol. 2020. PMID: 33448445

LAB strains isolated from grains and spontaneous sourdough of quinoa and amaranth were grown in the Man Rogosa and Sharpe medium where the inorganic phosphate (Pi) was replaced by 1% of IP6. Phytase activity was determined by measuring the Pi released from IP6. ...T …

LAB strains isolated from grains and spontaneous sourdough of quinoa and amaranth were grown in the Man Rogosa and Sharpe medium where the i …

67

Inositol phosphate kinases in the eukaryote landscape.

Laha D, Portela-Torres P, Desfougères Y, Saiardi A. Laha D, et al. Adv Biol Regul. 2021 Jan;79:100782. doi: 10.1016/j.jbior.2020.100782. Epub 2020 Dec 29. Adv Biol Regul. 2021. PMID: 33422459 Free PMC article.

Inositol phosphate encompasses a large multifaceted family of signalling molecules that originate from the combinatorial attachment of phosphate groups to the inositol ring. ...Surprisingly, the loss of IPPK, an enzyme thought to catalyse the rate limiting step of I …

Inositol phosphate encompasses a large multifaceted family of signalling molecules that originate from the combinatorial attachment o …

68

An update on vascular calcification and potential therapeutics.

Singh A, Tandon S, Tandon C. Singh A, et al. Mol Biol Rep. 2021 Jan;48(1):887-896. doi: 10.1007/s11033-020-06086-y. Epub 2021 Jan 4. Mol Biol Rep. 2021. PMID: 33394226 Review.

The interventions include phosphate binders, sodium thiosulphate, vitamin K, calcimimetics, vitamin D, bisphosphonates, Myoinositol hexaphosphate (IP6), Denosumab and TNAP inhibitors. Concurrently investigators are also working towards reversing or curing pathologic …

The interventions include phosphate binders, sodium thiosulphate, vitamin K, calcimimetics, vitamin D, bisphosphonates, Myoinositol hexap …

69

An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins.

Chen Q, Zhuo Y, Sharma P, Perez I, Francis DJ, Chakravarthy S, Vishnivetskiy SA, Berndt S, Hanson SM, Zhan X, Brooks EK, Altenbach C, Hubbell WL, Klug CS, Iverson TM, Gurevich VV. Chen Q, et al. J Mol Biol. 2021 Feb 19;433(4):166790. doi: 10.1016/j.jmb.2020.166790. Epub 2020 Dec 31. J Mol Biol. 2021. PMID: 33387531 Free PMC article.

These isoforms are ~75% identical and 85% similar; each binds numerous receptors, and appear to have many redundant functions, as demonstrated by studies of knockout mice. We previously showed that arrestin-3 can be activated by inositol-hexakisphosphate (IP(6)). IP(6) int …

These isoforms are ~75% identical and 85% similar; each binds numerous receptors, and appear to have many redundant functions, as demonstrat …

70

An Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase 1 Mutant with a 33-nt Deletion Showed Enhanced Tolerance to Salt and Drought Stress in Rice.

Jiang M, Liu Y, Li R, Li S, Tan Y, Huang J, Shu Q. Jiang M, et al. Plants (Basel). 2020 Dec 24;10(1):23. doi: 10.3390/plants10010023. Plants (Basel). 2020. PMID: 33374298 Free PMC article.

The comparative assay showed that the osipk1_1 mutant line had a significantly lower level of phytic acid (PA, IP(6); -19.5%) in rice grain and agronomic traits comparable to the WT. ...Further analyses showed that the transcription of stress response genes was sign …

The comparative assay showed that the osipk1_1 mutant line had a significantly lower level of phytic acid (PA, IP(6); -19.5%) …

71

Influence of exogenous phytase supplementation on phytate degradation, plasma inositol, alkaline phosphatase, and glucose concentrations of broilers at 28 days of age.

Kriseldi R, Johnson JA, Walk CL, Bedford MR, Dozier WA 3rd. Kriseldi R, et al. Poult Sci. 2021 Jan;100(1):224-234. doi: 10.1016/j.psj.2020.10.004. Epub 2020 Oct 12. Poult Sci. 2021. PMID: 33357685 Free PMC article.

Inositol is the final product of phytate degradation, which has the potential to serve as an indicator of phytase efficacy. ...Inositol liberation in the digesta of broilers fed diets with 1,200 FTU/kg phytase did not translate to increased plasma inositol co …

Inositol is the final product of phytate degradation, which has the potential to serve as an indicator of phytase efficacy. ...Ino …

72

Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application.

Vucenik I, Druzijanic A, Druzijanic N. Vucenik I, et al. Molecules. 2020 Dec 15;25(24):5931. doi: 10.3390/molecules25245931. Molecules. 2020. PMID: 33333775 Free PMC article. Review.

Multiple human health-beneficial effects have been related to highly phosphorylated inositol hexaphosphate (IP6). This naturally occurring carbohydrate and its parent compound, myo-inositol (Ins), are abundantly present in plants, particularly in certa …

Multiple human health-beneficial effects have been related to highly phosphorylated inositol hexaphosphate (IP6). This …

73

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis.

Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, Engelman AN, Ambrose Z, Rousso I, Perilla JR. Xu C, et al. PLoS Biol. 2020 Dec 17;18(12):e3001015. doi: 10.1371/journal.pbio.3001015. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33332391 Free PMC article.

Employing all-atom molecular dynamics (MD) simulations, we established that cooperative binding between nucleotides inside a CA hexamer cavity results in energetically favorable conditions for passive translocation of dNTPs into the HIV-1 capsid. Furthermore, binding of the host …

Employing all-atom molecular dynamics (MD) simulations, we established that cooperative binding between nucleotides inside a CA hexamer cavi …

74

Effect of phytic acid as an endodontic chelator on resin adhesion to sodium hypochlorite-treated dentin.

Nassar M, Hiraishi N, Islam MS, Romero MJ, Otsuki M, Tagami J. Nassar M, et al. Restor Dent Endod. 2020 Aug 24;45(4):e44. doi: 10.5395/rde.2020.45.e44. eCollection 2020 Nov. Restor Dent Endod. 2020. PMID: 33294409 Free PMC article.

OBJECTIVES: Phytic acid (IP6), a naturally occurring agent, has been previously reported as a potential alternative to ethylenediaminetetraacetic acid (EDTA). ...In the failure analysis, a distinctive feature was the presence of resin tags in samples c …

OBJECTIVES: Phytic acid (IP6), a naturally occurring agent, has been previously reported as a potential alternative to …

75

The Host Cell Metabolite Inositol Hexakisphosphate Promotes Efficient Endogenous HIV-1 Reverse Transcription by Stabilizing the Viral Capsid.

Jennings J, Shi J, Varadarajan J, Jamieson PJ, Aiken C. Jennings J, et al. mBio. 2020 Dec 1;11(6):e02820-20. doi: 10.1128/mBio.02820-20. mBio. 2020. PMID: 33262260 Free PMC article.

Here, we show that reverse transcription in purified HIV-1 cores is enhanced by the addition of the capsid-binding host cell metabolite inositol hexakisphosphate (IP6). IP6 potently enhanced full-length minus-strand synthesis, as did hexacarboxybenzene (HCB), …

Here, we show that reverse transcription in purified HIV-1 cores is enhanced by the addition of the capsid-binding host cell metabolite i …

76

MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia.

Ucuncu E, Rajamani K, Wilson MSC, Medina-Cano D, Altin N, David P, Barcia G, Lefort N, Banal C, Vasilache-Dangles MT, Pitelet G, Lorino E, Rabasse N, Bieth E, Zaki MS, Topcu M, Sonmez FM, Musaev D, Stanley V, Bole-Feysot C, Nitschké P, Munnich A, Bahi-Buisson N, Fossoud C, Giuliano F, Colleaux L, Burglen L, Gleeson JG, Boddaert N, Saiardi A, Cantagrel V. Ucuncu E, et al. Nat Commun. 2020 Nov 30;11(1):6087. doi: 10.1038/s41467-020-19919-y. Nat Commun. 2020. PMID: 33257696 Free PMC article.

Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse cellular functions. Therefore, tight regulation of inositol polyphosphate metabolism is essential for proper cell physiology. ...

Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse cellular functions. Therefore, tight regula …

77

Role of Inositols and Inositol Phosphates in Energy Metabolism.

Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I. Chatree S, et al. Molecules. 2020 Nov 1;25(21):5079. doi: 10.3390/molecules25215079. Molecules. 2020. PMID: 33139672 Free PMC article. Review.

Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. ...In addition, inosi …

Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6 …

78

Interactive effect of dietary calcium and phytase on broilers challenged with subclinical necrotic enteritis: part 2. Gut permeability, phytate ester concentrations, jejunal gene expression, and intestinal morphology.

Zanu HK, Kheravii SK, Morgan NK, Bedford MR, Swick RA. Zanu HK, et al. Poult Sci. 2020 Oct;99(10):4914-4928. doi: 10.1016/j.psj.2020.06.030. Epub 2020 Jul 3. Poult Sci. 2020. PMID: 32988528 Free PMC article.

Calcium has the capacity to interact with phytate-P to form Ca-phytate complexes and decrease the ability of exogenous phytase to degrade phytic acid. This study investigated the hypothesis that high dietary Ca would impair gut permeability, phytate esters (inosi …

Calcium has the capacity to interact with phytate-P to form Ca-phytate complexes and decrease the ability of exogenous phytase to degrade …

79

Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model.

Li C, Ci Y, Liu X, Chen C, Liu C, Li X, Li Q, Song Y. Li C, et al. Nutr Cancer. 2021;73(11-12):2306-2314. doi: 10.1080/01635581.2020.1820055. Epub 2020 Sep 16. Nutr Cancer. 2021. PMID: 32933338

To investigate the effects of inositol hexaphosphate (IP6) and inositol (INS) with capecitabine treatment on colorectal cancer (CRC) growth and liver metastasis in mice, we established an orthotopic xenograft mouse model. The study designated five expe …

To investigate the effects of inositol hexaphosphate (IP6) and inositol (INS) with capecitabine treatment on col …

80

Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles.

Ricana CL, Lyddon TD, Dick RA, Johnson MC. Ricana CL, et al. PLoS Pathog. 2020 Aug 10;16(8):e1008646. doi: 10.1371/journal.ppat.1008646. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32776974 Free PMC article.

Inositol hexakisphosphate (IP6) potently stimulates HIV-1 particle assembly in vitro and infectious particle production in vivo. However, knockout cells lacking inositol-pentakisphosphate 2-kinase (IPPK-KO), the enzyme that produces IP6 by phosphorylat …

Inositol hexakisphosphate (IP6) potently stimulates HIV-1 particle assembly in vitro and infectious particle production in viv …

81

Phytase catalysis of dephosphorylation studied using isothermal titration calorimetry and electrospray ionization time-of-flight mass spectroscopy.

Kempapidis T, Bradshaw NJ, Hodges HE, Cowieson AJ, Cameron DD, Falconer RJ. Kempapidis T, et al. Anal Biochem. 2020 Oct 1;606:113859. doi: 10.1016/j.ab.2020.113859. Epub 2020 Jul 29. Anal Biochem. 2020. PMID: 32738211

Phytases are important commercial enzymes that catalyze the dephosphorylation of myo-inositol hexakisphosphate (phytate) to its lower inositol phosphate (IP) esters, IP6 to IP1. ...

Phytases are important commercial enzymes that catalyze the dephosphorylation of myo-inositol hexakisphosphate (phytate) to its lower …

82

In Vitro Quantification of the Effects of IP6 and Other Small Polyanions on Immature HIV-1 Particle Assembly and Core Stability.

Dostálková A, Kaufman F, Křížová I, Vokatá B, Ruml T, Rumlová M. Dostálková A, et al. J Virol. 2020 Sep 29;94(20):e00991-20. doi: 10.1128/JVI.00991-20. Print 2020 Sep 29. J Virol. 2020. PMID: 32727872 Free PMC article.

These processes are facilitated by several host-cell factors, one of which is myo-inositol hexaphosphate (IP6). IP6 participates in the proper assembly of Gag into immature hexameric lattices and is incorporated into HIV-1 particles. ...One of these fa …

These processes are facilitated by several host-cell factors, one of which is myo-inositol hexaphosphate (IP6). IP6 …

83

Chemoprotective effects of inositol hexaphosphate against cyclophosphamide-induced testicular damage in rats.

Alkhalaf MI, Alansari WS, Alshubaily FA, Alnajeebi AM, Eskandrani AA, Tashkandi MA, Babteen NA. Alkhalaf MI, et al. Sci Rep. 2020 Jul 28;10(1):12599. doi: 10.1038/s41598-020-68608-9. Sci Rep. 2020. PMID: 32724173 Free PMC article.

Cyclophosphamide (CP) is commonly used as an anticancer agent but has been associated with high toxicity in several animal organs, including the testes. Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in foods with high fibre …

Cyclophosphamide (CP) is commonly used as an anticancer agent but has been associated with high toxicity in several animal organs, including …

84

Safety evaluation of a novel variant of consensus bacterial phytase.

Ladics GS, Han KH, Jang MS, Park H, Marshall V, Dersjant-Li Y, Sewalt VJ. Ladics GS, et al. Toxicol Rep. 2020 Jul 15;7:844-851. doi: 10.1016/j.toxrep.2020.07.004. eCollection 2020. Toxicol Rep. 2020. PMID: 32714839 Free PMC article.

85

Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis.

Perelló J, Ferrer MD, Del Mar Pérez M, Kaesler N, Brandenburg VM, Behets GJ, D'Haese PC, Garg R, Isern B, Gold A, Wolf M, Salcedo C. Perelló J, et al. Br J Pharmacol. 2020 Oct;177(19):4400-4415. doi: 10.1111/bph.15163. Epub 2020 Aug 23. Br J Pharmacol. 2020. PMID: 32557649 Free PMC article.

86

Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate-mediated regulation of cullin-RING ligase and sensitize cancer cells to MLN4924/pevonedistat.

Zhang X, Shi S, Su Y, Yang X, He S, Yang X, Wu J, Zhang J, Rao F. Zhang X, et al. J Biol Chem. 2020 Jul 24;295(30):10281-10292. doi: 10.1074/jbc.RA120.014375. Epub 2020 Jun 3. J Biol Chem. 2020. PMID: 32493769 Free PMC article.

Inositol hexakisphosphate (IP(6)) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate (IP(5)) by the single IP(5) 2-kinase (IP5K). ...

Inositol hexakisphosphate (IP(6)) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate (IP(5)) by t …

87

Dietary phytate has a greater anti-nutrient effect on feed conversion ratio compared to body weight gain and greater doses of phytase are required to alleviate this effect as evidenced by prediction equations on growth performance, bone ash and phytate degradation in broilers.

Walk CL, Rama Rao SV. Walk CL, et al. Poult Sci. 2020 Jan;99(1):246-255. doi: 10.3382/ps/pez469. Epub 2019 Dec 30. Poult Sci. 2020. PMID: 32416808 Free PMC article.

Tibia ash weight, percent or Ca concentration were maximized at phytate P concentrations <0.24, 0.296, or 0.24%, respectively and phytase supplementation at 822 or >2,000 FTU/kg maximized tibia ash weight or percent respectively. In the absence of phytase, phytate (IP6 …

Tibia ash weight, percent or Ca concentration were maximized at phytate P concentrations <0.24, 0.296, or 0.24%, respectively and phytase …

88

Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/beta-Catenin Pathway.

Liu X, Liu C, Chen C, Sun W, Ci Y, Li Q, Song Y. Liu X, et al. Onco Targets Ther. 2020 Apr 16;13:3223-3235. doi: 10.2147/OTT.S247646. eCollection 2020. Onco Targets Ther. 2020. PMID: 32368081 Free PMC article.

INTRODUCTION: Colorectal cancer, one of the most common tumors, is mainly fatal because of the occurrence of liver metastasis. Inositol hexaphosphate (IP6) and inositol (INS) were found, both, in vitro and in vivo to play an anti-tumor effect, whereas …

INTRODUCTION: Colorectal cancer, one of the most common tumors, is mainly fatal because of the occurrence of liver metastasis. Inositol …

89

Erosive Potential of 1% Phytic Acid on Radicular Dentine at Different Time Intervals.

Afshan Z, Jat SA, Khan JA, Hasan A, Rehman Qazi FU. Afshan Z, et al. Eur Endod J. 2020 Mar 17;5(1):28-34. doi: 10.14744/eej.2019.02411. eCollection 2020. Eur Endod J. 2020. PMID: 32342035 Free PMC article.

OBJECTIVE: The objective of this in-vitro study was to compare the erosive potential and smear layer removal ability of 1% Phytic acid (IP6) and 17% Ethylenediaminetetaacetic acid (EDTA). METHODS: Canal preparation of 225 single rooted extracted human …

OBJECTIVE: The objective of this in-vitro study was to compare the erosive potential and smear layer removal ability of 1% Phytic …

90

Towards understanding the antagonistic activity of phytic acid against common foodborne bacterial pathogens using a general linear model.

Boukhris I, Smaoui S, Ennouri K, Morjene N, Farhat-Khemakhem A, Blibech M, Alghamdi OA, Chouayekh H. Boukhris I, et al. PLoS One. 2020 Apr 17;15(4):e0231397. doi: 10.1371/journal.pone.0231397. eCollection 2020. PLoS One. 2020. PMID: 32302332 Free PMC article.

Therefore, in the present study, we investigated for the first time the antibacterial potential of phytic acid (myo-inositol hexakisphosphate, IP6), a natural molecule that is 'generally recognized as safe' (FDA classification), against the proliferati …

Therefore, in the present study, we investigated for the first time the antibacterial potential of phytic acid (myo-inosito …

91

Phytic acid exerts protective effects in cerebral ischemia-reperfusion injury by activating the anti-oxidative protein sestrin2.

Liu J, Li Y, Mei C, Ning X, Pang J, Gu L, Wu L. Liu J, et al. Biosci Biotechnol Biochem. 2020 Jul;84(7):1401-1408. doi: 10.1080/09168451.2020.1754158. Epub 2020 Apr 14. Biosci Biotechnol Biochem. 2020. PMID: 32290775

This investigation aims to investigate the protective effects of phytic acid (IP6) for cerebral I/R injury in vitro. PC-12 cells under Oxygen and glucose deprivation/reperfusion (OGD/R) were performed to mimic cerebral I/R. IP6 was pretreated before PC …

This investigation aims to investigate the protective effects of phytic acid (IP6) for cerebral I/R injury in vitro. PC …

92

New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review.

Omoruyi FO, Stennett D, Foster S, Dilworth L. Omoruyi FO, et al. Molecules. 2020 Apr 10;25(7):1720. doi: 10.3390/molecules25071720. Molecules. 2020. PMID: 32290029 Free PMC article. Review.

Natural alternatives to pharmaceuticals are being sought, and this has led to studies involving inositol, and myo-inositol-hexakisphosphate, also referred to as IP6. ...Current research activities have been focusing on the mechanisms of action of inositol …

Natural alternatives to pharmaceuticals are being sought, and this has led to studies involving inositol, and myo-inositol-hex …

93

Cooking Effect on the Bioactive Compounds, Texture, and Color Properties of Cold-Extruded Rice/Bean-Based Pasta Supplemented with Whole Carob Fruit.

Arribas C, Cabellos B, Cuadrado C, Guillamón E, Pedrosa MM. Arribas C, et al. Foods. 2020 Apr 2;9(4):415. doi: 10.3390/foods9040415. Foods. 2020. PMID: 32252323 Free PMC article.

The highest total inositol phosphates and protease inhibitors contents were found in the samples with a higher bean percentage. After cooking, the content of total inositol phosphates ranged from 2.12 to 7.97 mg/g (phytic acid or inositol hex …

The highest total inositol phosphates and protease inhibitors contents were found in the samples with a higher bean percentage. After …

94

A Legionella effector kinase is activated by host inositol hexakisphosphate.

Sreelatha A, Nolan C, Park BC, Pawłowski K, Tomchick DR, Tagliabracci VS. Sreelatha A, et al. J Biol Chem. 2020 May 1;295(18):6214-6224. doi: 10.1074/jbc.RA120.013067. Epub 2020 Mar 30. J Biol Chem. 2020. PMID: 32229585 Free PMC article.

Importantly, we found that the eukaryote-specific host signaling molecule inositol hexakisphosphate (IP6) is required for Lpg2603 kinase activity. Crystal structures of Lpg2603 in the apo-form and when bound to IP6 revealed an active-site rearrangement that a …

Importantly, we found that the eukaryote-specific host signaling molecule inositol hexakisphosphate (IP6) is required for Lpg2 …

95

Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.

Mukherjee S, Haubner J, Chakraborty A. Mukherjee S, et al. Molecules. 2020 Mar 19;25(6):1403. doi: 10.3390/molecules25061403. Molecules. 2020. PMID: 32204420 Free PMC article. Review.

In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. ...

In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from I …

96

Quantitative measures of myo-IP₆ in soil using solution ³¹P NMR spectroscopy and spectral deconvolution fitting including a broad signal.

Reusser JE , Verel R , Frossard E , McLaren TI . Reusser JE , et al. Environ Sci Process Impacts. 2020 Apr 29;22(4):1084-1094. doi: 10.1039/c9em00485h. Environ Sci Process Impacts. 2020. PMID: 32191230

Inositol phosphates, particularly myo-inositol hexakisphosphate (myo-IP6), are an important pool of soil organic phosphorus (P) in terrestrial ecosystems. ...The recovery of individual peaks of myo-IP6 differed, most notably, the C5 phosphate peak of m …

Inositol phosphates, particularly myo-inositol hexakisphosphate (myo-IP6), are an important pool of soil organic phosph …

97

Allelic Variants of CRISPR/Cas9 Induced Mutation in an Inositol Trisphosphate 5/6 Kinase Gene Manifest Different Phenotypes in Barley.

Vlčko T, Ohnoutková L. Vlčko T, et al. Plants (Basel). 2020 Feb 5;9(2):195. doi: 10.3390/plants9020195. Plants (Basel). 2020. PMID: 32033421 Free PMC article.

Inositol trisphosphate 5/6 kinases (ITPK) constitute a small group of enzymes participating in the sequential phosphorylation of inositol phosphate to inositol hexakisphosphate (IP6), which is a major storage form of phosphate in cereal grains. The dev …

Inositol trisphosphate 5/6 kinases (ITPK) constitute a small group of enzymes participating in the sequential phosphorylation of i …

98

Identification and quantification of myo-inositol hexakisphosphate in complex environmental matrices using ion chromatography and high-resolution mass spectrometry in comparison to (31)P NMR spectroscopy.

McIntyre CA, Arkell JJL, Arthur CJ, Lawrence PG, Butts CP, Lloyd CEM, Johnes PJ, Evershed RP. McIntyre CA, et al. Talanta. 2020 Apr 1;210:120188. doi: 10.1016/j.talanta.2019.120188. Epub 2019 Jul 31. Talanta. 2020. PMID: 31987164

Myo-inositol hexakisphosphate, or phytic acid, (myo-IP6) is a key organic phosphorus (P) compound in soils and manures. ...The myo-IP6 was identified in the NMR by comparing spectra of extracts of soils with and without authentic myo-IP6 …

Myo-inositol hexakisphosphate, or phytic acid, (myo-IP6) is a key organic phosphorus (P) compound in soils and m …

99

Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly.

Dick RA, Xu C, Morado DR, Kravchuk V, Ricana CL, Lyddon TD, Broad AM, Feathers JR, Johnson MC, Vogt VM, Perilla JR, Briggs JAG, Schur FKM. Dick RA, et al. PLoS Pathog. 2020 Jan 27;16(1):e1008277. doi: 10.1371/journal.ppat.1008277. eCollection 2020 Jan. PLoS Pathog. 2020. PMID: 31986188 Free PMC article.

Among retroviruses the inter- and intra-hexamer contacts differ, especially in the N-terminal sub-domain of CA (CANTD). For HIV-1 the cellular molecule inositol hexakisphosphate (IP6) interacts with and stabilizes the immature hexamer, and is required for production …

Among retroviruses the inter- and intra-hexamer contacts differ, especially in the N-terminal sub-domain of CA (CANTD). For HIV-1 the cellul …

100

Exploring the Potential Relationship Between Phytate Ingestion, Urinary Phytate Excretion, and Renal Stone Risk in a Unique Human Model: No Hard Evidence in Support of Phytate as a Stone Inhibitor.

Fakier S, Rodgers A. Fakier S, et al. J Ren Nutr. 2020 Sep;30(5):396-403. doi: 10.1053/j.jrn.2019.10.006. Epub 2020 Jan 9. J Ren Nutr. 2020. PMID: 31928801

Dietary intake of IP6 was restricted for 18 days. An IP6 dietary supplement was ingested on days 15-18. ...We conclude that, in the absence of hard evidence, claims that IP6 is a stone inhibitor remain unproven....

Dietary intake of IP6 was restricted for 18 days. An IP6 dietary supplement was ingested on days 15-18. ...We conclude that, i …

101

Effect of Instant Controlled Pressure-Drop (DIC), Cooking and Germination on Non-Nutritional Factors of Common Vetch (Vicia sativa spp.).

Hernandez-Aguirre AI, Téllez-Pérez C, San Martín-Azócar A, Cardador-Martínez A. Hernandez-Aguirre AI, et al. Molecules. 2019 Dec 30;25(1):151. doi: 10.3390/molecules25010151. Molecules. 2019. PMID: 31905949 Free PMC article.

Legumes are widely consumed by humans, being an important source of nutrients; however, they contain non-nutritional factors (NNFs), such as phytic acid (IP(6)), raffinose, stachyose, total phenolic compounds, condensed tannins, and flavonoids, that have negative ef …

Legumes are widely consumed by humans, being an important source of nutrients; however, they contain non-nutritional factors (NNFs), such as …

102

Cellular IP₆ Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP₆ Are Attenuated for Infection and Replication.

Mallery DL, Faysal KMR, Kleinpeter A, Wilson MSC, Vaysburd M, Fletcher AJ, Novikova M, Böcking T, Freed EO, Saiardi A, James LC. Mallery DL, et al. Cell Rep. 2019 Dec 17;29(12):3983-3996.e4. doi: 10.1016/j.celrep.2019.11.050. Cell Rep. 2019. PMID: 31851928 Free PMC article.

Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP(6)) for viral production and primary cell replication. ...

Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP(6)) for viral production and primary c …

103

Effect of Different Dentin Conditioning Agents on Growth Factor Release, Mesenchymal Stem Cell Attachment and Morphology.

Atesci AA, Avci CB, Tuglu MI, Ozates Ay NP, Eronat AC. Atesci AA, et al. J Endod. 2020 Feb;46(2):200-208. doi: 10.1016/j.joen.2019.10.033. Epub 2019 Dec 4. J Endod. 2020. PMID: 31812361

METHODS: Transforming growth factor beta 1, vascular endothelial growth factor, bone morphogenetic protein 2, and fibroblast growth factor 2 release from prepared dentin discs conditioned with 17% EDTA, 10% citric acid, 1% phytic acid (IP6), or 37% pho …

METHODS: Transforming growth factor beta 1, vascular endothelial growth factor, bone morphogenetic protein 2, and fibroblast growth factor 2 …

104

Biochemical Reconstitution of HIV-1 Assembly and Maturation.

Kucharska I, Ding P, Zadrozny KK, Dick RA, Summers MF, Ganser-Pornillos BK, Pornillos O. Kucharska I, et al. J Virol. 2020 Feb 14;94(5):e01844-19. doi: 10.1128/JVI.01844-19. Print 2020 Feb 14. J Virol. 2020. PMID: 31801870 Free PMC article.

Here, we report the development of a biochemical reconstitution system that allowed us to investigate how Gag lattice formation, RNA binding, and the assembly cofactor inositol hexakisphosphate (IP6) synergize to generate immature virus particles in vitro The result …

Here, we report the development of a biochemical reconstitution system that allowed us to investigate how Gag lattice formation, RNA binding …

105

Direct Cloning Method for Expression of Recombinant Proteins with an Inositol Hexakisphosphate Inducible Self-Cleaving Tag.

Kwon K, Biancucci M, Woida PJ, Satchell KJF. Kwon K, et al. Methods Mol Biol. 2020;2091:163-179. doi: 10.1007/978-1-0716-0167-9_15. Methods Mol Biol. 2020. PMID: 31773580

An efficient self-cleavage C-terminal fusion system was developed using the inositol hexakisphosphate-inducible Vibrio cholerae MARTX(Vc) toxin cysteine protease domain (CPD). ...

An efficient self-cleavage C-terminal fusion system was developed using the inositol hexakisphosphate-inducible Vibrio cholerae MARTX …

106

Magnesium Phosphate Cement as Mineral Bone Adhesive.

Brückner T, Meininger M, Groll J, Kübler AC, Gbureck U. Brückner T, et al. Materials (Basel). 2019 Nov 21;12(23):3819. doi: 10.3390/ma12233819. Materials (Basel). 2019. PMID: 31766321 Free PMC article.

The cements were obtained from a mixture of farringtonite (Mg(3)(PO(4))(2)) with different amounts of phytic acid (C(6)H(18)O(24)P(6), inositol hexaphosphate, IP6), whereas cement setting occurred by a chelation reaction between Mg(2+) ions and …

The cements were obtained from a mixture of farringtonite (Mg(3)(PO(4))(2)) with different amounts of phytic acid (C(6)H(18)O( …

107

Regulation of MicroRNA-155 and Its Related Genes Expression by Inositol Hexaphosphate in Colon Cancer Cells.

Kapral M, Wawszczyk J, Węglarz L. Kapral M, et al. Molecules. 2019 Nov 16;24(22):4153. doi: 10.3390/molecules24224153. Molecules. 2019. PMID: 31744065 Free PMC article.

Inositol hexaphosphate (IP6), a natural dietary component, has been found as an antitumor agent by stimulating apoptosis and inhibiting cancer cell proliferation, their migration, and metastasis in diverse cancers including colon cancer. ...Moreover, the expr …

Inositol hexaphosphate (IP6), a natural dietary component, has been found as an antitumor agent by stimulating apoptosi …

108

Amyloid-β Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation.

Lu J, Li Y, Mollinari C, Garaci E, Merlo D, Pei G. Lu J, et al. Curr Alzheimer Res. 2019;16(10):934-949. doi: 10.2174/1567205016666191023104036. Curr Alzheimer Res. 2019. PMID: 31642778

NHEJ components, such as Ku70/80, DNA-PKcs, and XRCC4, are localized in mitochondria and silencing of XRCC4 significantly exacerbates the effect of Abeta42O on mtDNA integrity. On the contrary, pre-treatment with Phytic Acid (IP6), which specifically stimulat …

NHEJ components, such as Ku70/80, DNA-PKcs, and XRCC4, are localized in mitochondria and silencing of XRCC4 significantly exacerbates the ef …

109

Optimization of Inositol Hexaphosphate Colon Targeted Formulation for Anticarcinogenic Marker Modulation.

Mishra N, Arya M, Gupta KP, Saraf SA. Mishra N, et al. AAPS PharmSciTech. 2019 Oct 22;20(8):319. doi: 10.1208/s12249-019-1529-2. AAPS PharmSciTech. 2019. PMID: 31641892

Currently, natural compounds are being looked up to, for subversion and deterrence of cancers. Inositol hexaphosphate (IP6) is one such naturally occurring phosphorylated carbohydrate present in most legumes and cereals which acts as a potential antineoplasti …

Currently, natural compounds are being looked up to, for subversion and deterrence of cancers. Inositol hexaphosphate (IP6 …

110

Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview.

Vucenik I. Vucenik I. J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S18-S22. doi: 10.3177/jnsv.65.S18. J Nutr Sci Vitaminol (Tokyo). 2019. PMID: 31619624 Free article. Review.

Inositol hexaphosphate (IP(6)) and its parent compound myo-inositol (Ins) are active compounds from rice and other grains, with a broad spectrum of biological activities important in health and diseases. ...

Inositol hexaphosphate (IP(6)) and its parent compound myo-inositol (Ins) are active compounds from rice and other grai …

111

Anti-cancer activity of the cell membrane-permeable phytic acid prodrug.

Masunaga T, Murao N, Tateishi H, Koga R, Ohsugi T, Otsuka M, Fujita M. Masunaga T, et al. Bioorg Chem. 2019 Nov;92:103240. doi: 10.1016/j.bioorg.2019.103240. Epub 2019 Sep 4. Bioorg Chem. 2019. PMID: 31525525

Phytic acid (IP6) is an ingredient in cereals and legumes, and limited amounts of this compound are considered to enter the cell and exert anti-cancer effects. ...To overcome this problem, we synthesized a prodrug of IP6 (Pro-IP6) and elucidated …

Phytic acid (IP6) is an ingredient in cereals and legumes, and limited amounts of this compound are considered to enter …

112

SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification.

Zabirnyk A, Ferrer MD, Bogdanova M, Pérez MM, Salcedo C, Kaljusto ML, Kvitting JP, Stensløkken KO, Perelló J, Vaage J. Zabirnyk A, et al. Vascul Pharmacol. 2019 Nov-Dec;122-123:106583. doi: 10.1016/j.vph.2019.106583. Epub 2019 Aug 19. Vascul Pharmacol. 2019. PMID: 31437530 Free article.

The purpose of the present study was to investigate whether SNF472, the hexasodium salt of myo-inositol hexaphosphate (IP6 or phytate): 1. Inhibits induced calcification in cultured aortic valve interstitial cells (VIC) as an in vitro model of aortic valve st …

The purpose of the present study was to investigate whether SNF472, the hexasodium salt of myo-inositol hexaphosphate (IP6 …

113

Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation.

Lin C, Mendoza-Espinosa P, Rouzina I, Guzmán O, Moreno-Razo JA, Francisco JS, Bruinsma R. Lin C, et al. PLoS One. 2019 Aug 22;14(8):e0221256. doi: 10.1371/journal.pone.0221256. eCollection 2019. PLoS One. 2019. PMID: 31437199 Free PMC article.

Sequence analysis shows high conservation within the newly-found intra-Gag MA/CActd binding site, as well as its spatial proximity to other well known elements of Gag -such as CActd's SP1 helix region, its inositol hexaphosphate (IP6) binding site and major h …

Sequence analysis shows high conservation within the newly-found intra-Gag MA/CActd binding site, as well as its spatial proximity to other …

114

FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.

Huang PT, Summers BJ, Xu C, Perilla JR, Malikov V, Naghavi MH, Xiong Y. Huang PT, et al. Cell Rep. 2019 Aug 27;28(9):2373-2385.e7. doi: 10.1016/j.celrep.2019.07.079. Epub 2019 Aug 14. Cell Rep. 2019. PMID: 31422020 Free PMC article.

The FEZ1-capsid interaction directly competes with nucleotides and inositol hexaphosphate (IP6) that bind at the same location. In addition, all-atom molecular dynamic (MD) simulations establish the molecular details of FEZ1-capsid interactions. ...

The FEZ1-capsid interaction directly competes with nucleotides and inositol hexaphosphate (IP6) that bind at the same l …

115

Ultrasensitive fluorometric determination of iron(iii) and inositol hexaphosphate in cancerous and bacterial cells by using carbon dots with bright yellow fluorescence.

Cui F , Sun J , Yang X , Ji J , Pi F , Zhang Y , Lei H , Sun X . Cui F , et al. Analyst. 2019 Aug 5;144(16):5010-5021. doi: 10.1039/c9an00968j. Analyst. 2019. PMID: 31334745

An ON-OFF-ON dual-function fluorescent nanoprobe is described for the trace detection of ferric ions and inositol hexaphosphate (IP6) in living cells. It is based on the use of yellow-fluorescent nitrogen-doped carbon dots (YN-CDs). ...The resulting ON-OFF-ON …

An ON-OFF-ON dual-function fluorescent nanoprobe is described for the trace detection of ferric ions and inositol hexaphosphate …

116

The efficacy of 2 phytases on inositol phosphate degradation in different segments of the gastrointestinal tract, calcium and phosphorus digestibility, and bone quality of broilers.

Bello A, Dersjant-Li Y, Korver DR. Bello A, et al. Poult Sci. 2019 Nov 1;98(11):5789-5800. doi: 10.3382/ps/pez375. Poult Sci. 2019. PMID: 31265114 Free PMC article.

The anti-nutritional effects of dietary inositol phosphates (IP6 through IP3) have been recognized in broiler chickens; however, inositol hexaphosphate (IP6) is more potent than the lower IP esters. ...The ileal IP6 levels were decreased …

The anti-nutritional effects of dietary inositol phosphates (IP6 through IP3) have been recognized in broiler chickens; howeve …

117

Setting Mechanism of a CDHA Forming α-TCP Cement Modified with Sodium Phytate for Improved Injectability.

Weichhold J, Gbureck U, Goetz-Neunhoeffer F, Hurle K. Weichhold J, et al. Materials (Basel). 2019 Jun 29;12(13):2098. doi: 10.3390/ma12132098. Materials (Basel). 2019. PMID: 31261865 Free PMC article.

The injectability of the cement paste was drastically increased by the IP6 addition, independent of the amount of added IP6. Additionally, the cement paste viscosity during the first minutes decreased. These effects could be clearly related to a slightly more negati …

The injectability of the cement paste was drastically increased by the IP6 addition, independent of the amount of added IP6. A …

118

Effect of Inositol Hexaphosphate (IP(6)) on Serum Uric Acid in Hyperuricemic Subjects: a Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Ikenaga T, Kakumoto K, Kohda N, Yamamoto T. Ikenaga T, et al. Plant Foods Hum Nutr. 2019 Sep;74(3):316-321. doi: 10.1007/s11130-019-00735-9. Plant Foods Hum Nutr. 2019. PMID: 31119466 Clinical Trial.

Inositol hexaphosphate (IP(6)), a food constituent with various health benefits, has been shown to suppress postprandial elevations of serum uric acid (SUA) levels in healthy adults by inhibiting purine nucleoside and base absorption. ...The urinary uric a …

Inositol hexaphosphate (IP(6)), a food constituent with various health benefits, has been shown to suppress postprandial eleva …

119

Development of the FAO/INFOODS/IZINCG Global Food Composition Database for Phytate.

Dahdouh S, Grande F, Espinosa SN, Vincent A, Gibson R, Bailey K, King J, Rittenschober D, Charrondière UR. Dahdouh S, et al. J Food Compost Anal. 2019 May;78:42-48. doi: 10.1016/j.jfca.2019.01.023. J Food Compost Anal. 2019. PMID: 31057213 Free PMC article.

120

Reduction of β-ODAP and IP₆ contents in Lathyrus sativus L. seed by high hydrostatic pressure.

Buta MB, Emire SA, Posten C, Andrée S, Greiner R. Buta MB, et al. Food Res Int. 2019 Jun;120:73-82. doi: 10.1016/j.foodres.2019.02.011. Epub 2019 Feb 14. Food Res Int. 2019. PMID: 31000291

Grass pea (Lathyrus sativus L.) seeds contain an endogenous neurotoxic non-proteinogenic amino acid, beta-N-oxalyl-l-alpha,beta-diaminopropionic acid (beta-ODAP), a major limiting factor-for their human consumption. ...

Grass pea (Lathyrus sativus L.) seeds contain an endogenous neurotoxic non-proteinogenic amino acid, beta-N-oxalyl-l-alpha,beta-diami …

121

Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature.

I Ciftci H, G Sierra R, Yoon CH, Su Z, Tateishi H, Koga R, Kotaro K, Yumoto F, Senda T, Liang M, Wakatsuki S, Otsuka M, Fujita M, DeMirci H. I Ciftci H, et al. Int J Mol Sci. 2019 Apr 3;20(7):1675. doi: 10.3390/ijms20071675. Int J Mol Sci. 2019. PMID: 30987231 Free PMC article.

Here, we report the first X-ray free-electron laser (XFEL) study of the HIV-1 MA domain's interaction with inositol hexaphosphate (IP6), a phospholipid headgroup mimic. We also describe the purification, characterization and microcrystallization of two MA cry …

Here, we report the first X-ray free-electron laser (XFEL) study of the HIV-1 MA domain's interaction with inositol hexaphosphate …

122

PI3K/Akt Pathway and miR-21 are Involved in N-Ethyl-N-Nitrosourea-Induced F1 Mouse Lung Tumorigenesis: Effect of Inositol Hexaphosphate.

Sahay S, Tiwari P, Pandey M, Gupta KP. Sahay S, et al. J Environ Pathol Toxicol Oncol. 2019;38(1):69-81. doi: 10.1615/JEnvironPatholToxicolOncol.2018026684. J Environ Pathol Toxicol Oncol. 2019. PMID: 30806292

In this study, we explored the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and microRNA-21 (miR-21) in transplacental lung tumorigenesis and its prevention by dietary compound inositol hexaphosphate (IP6) in F1 mice. Balb/c mice were e …

In this study, we explored the involvement of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and microRNA-21 (miR-21) in transplacenta …

123

In vitro and in silico molecular interaction of multiphase nanoparticles containing inositol hexaphosphate and jacalin: Therapeutic potential against colon cancer cells (HCT-15).

Arya M, Mishra N, Singh P, Tripathi CB, Parashar P, Singh M, Gupta KP, Saraf SA. Arya M, et al. J Cell Physiol. 2019 Sep;234(9):15527-15536. doi: 10.1002/jcp.28200. Epub 2019 Jan 29. J Cell Physiol. 2019. PMID: 30697733

Inositol hexaphosphate (IP6) is a natural constituent found in almost all cereals and legumes. ...The current study was in-quested to develop and evaluate a surface-modified gold nanoparticulate system containing IP6 and jacalin which may maximize the …

Inositol hexaphosphate (IP6) is a natural constituent found in almost all cereals and legumes. ...The current study was …

124

Raman tracking the activity of urease in saliva for healthcare.

Hu S, Gao Y, Wu Y, Guo X, Ying Y, Wen Y, Yang H. Hu S, et al. Biosens Bioelectron. 2019 Mar 15;129:24-28. doi: 10.1016/j.bios.2018.12.059. Epub 2019 Jan 15. Biosens Bioelectron. 2019. PMID: 30682685

Herein, a rapid surface enhanced Raman scattering (SERS) method is proposed to determine the activity of urease by using inositol hexaphosphate (IP(6)) stabilized silver nanoparticles (AgNPs@IP(6)) as an efficient SERS-active substrate. ...

Herein, a rapid surface enhanced Raman scattering (SERS) method is proposed to determine the activity of urease by using inositol …

125

Photocatalytic Self-Cleaning Cotton Fabrics Coated by Cu₂(OH)PO₄ under VIS/NIR Irradiation.

Gao D, Wang L, Wang C, Chen T. Gao D, et al. Materials (Basel). 2019 Jan 11;12(2):238. doi: 10.3390/ma12020238. Materials (Basel). 2019. PMID: 30642001 Free PMC article.

In the present work, a mild strategy was employed to obtain cotton fabrics (CFs) coated with Cu2(OH)PO4 (CHP) nanoparticles to achieve self-cleaning property. The phytic acid (IP6) assisted method was employed to synthesize nanoparticles (CHP-IP6). The …

In the present work, a mild strategy was employed to obtain cotton fabrics (CFs) coated with Cu2(OH)PO4 (CHP) nanoparticles to achieve self- …

126

Phytic Acid Decreases Oxidative Stress and Intestinal Lesions Induced by Fumonisin B1 and Deoxynivalenol in Intestinal Explants of Pigs.

da Silva EO, Gerez JR, Hohmann MSN, Verri WA Jr, Bracarense APFRL. da Silva EO, et al. Toxins (Basel). 2019 Jan 4;11(1):18. doi: 10.3390/toxins11010018. Toxins (Basel). 2019. PMID: 30621150 Free PMC article.

The purpose of the present study was to investigate the effects of phytic acid (IP6) on morphological and immunohistochemical parameters and oxidative stress response in intestinal explants of pigs exposed to fumonisin B1 (FB1) and/or deoxynivalenol (DON). Th …

The purpose of the present study was to investigate the effects of phytic acid (IP6) on morphological and immunohistoch …

127

Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma: a case report.

Khurana S, Baldeo C, Joseph RW. Khurana S, et al. Melanoma Res. 2019 Jun;29(3):322-324. doi: 10.1097/CMR.0000000000000577. Melanoma Res. 2019. PMID: 30615010

Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. ...On the basis of this case and previous preclinical studies, we believe furthe …

Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found …

128

Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation.

Kato A, Hirakawa Y, Hiraoka W. Kato A, et al. Fujita Med J. 2019;5(4):98-103. doi: 10.20407/fmj.2018-020. Epub 2019 Sep 25. Fujita Med J. 2019. PMID: 35111510 Free PMC article.

OBJECTIVES: The objective of this study was to identify the role of reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, in inositol hexaphosphate (IP6)-induced metabolic disruption in human leukemia PLB-985 …

OBJECTIVES: The objective of this study was to identify the role of reactive oxygen species (ROS) generated by nicotinamide adenine dinucleo …

129

Phytase as an alleviator of high-temperature stress in broilers fed adequate and low dietary calcium.

Lee SA, Nagalakshmi D, Raju MVLN, Rao SVR, Bedford MR, Walk CL. Lee SA, et al. Poult Sci. 2019 May 1;98(5):2122-2132. doi: 10.3382/ps/pey566. Poult Sci. 2019. PMID: 30597079 Free article.

This study aimed to investigate the effect of phytase and dietary Ca level on performance, phytate (inositol hexa-phosphate, IP6) concentration, and anti-oxidant enzyme activity in broilers exposed to cycling high environmental temperatures. ...Phytase and low dieta …

This study aimed to investigate the effect of phytase and dietary Ca level on performance, phytate (inositol hexa-phosphate, IP6 …

130

Effect of dentine conditioning with phytic acid or etidronic acid on growth factor release, dental pulp stem cell migration and viability.

Deniz Sungur D, Aksel H, Ozturk S, Yılmaz Z, Ulubayram K. Deniz Sungur D, et al. Int Endod J. 2019 Jun;52(6):838-846. doi: 10.1111/iej.13066. Epub 2019 Jan 18. Int Endod J. 2019. PMID: 30585644

The dentine discs were then exposed to 17% ethylenediaminetetraacetic acid (EDTA), 1% phytic acid (IP6), 9% etidronic acid (HEDP) or distilled water (DW). ...In terms of cell migration, HEDP was more effective than EDTA (P < 0.05) whilst I

…

The dentine discs were then exposed to 17% ethylenediaminetetraacetic acid (EDTA), 1% phytic acid (IP6), 9% etid …

131

Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets.

Arya M, Singh P, Tripathi CB, Parashar P, Singh M, Kanoujia J, Guleria A, Kaithwas G, Gupta KP, Saraf SA. Arya M, et al. Drug Deliv Transl Res. 2019 Feb;9(1):53-65. doi: 10.1007/s13346-018-00605-y. Drug Deliv Transl Res. 2019. PMID: 30484258

Phytic acid (PA) has momentous chemotherapeutic potential. Due to the chelate formation and rapid elimination, it is not popular in cancer treatment. The present work was inquested to develop a surface-modified nanoformulation of PA which prevents its speedy elimina …

Phytic acid (PA) has momentous chemotherapeutic potential. Due to the chelate formation and rapid elimination, it is not popul …

132

Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy.

Ivarsson ME, Durantie E, Huberli C, Huwiler S, Hegde C, Friedman J, Altamura F, Lu J, Verdu EF, Bercik P, Logan SM, Chen W, Leroux JC, Castagner B. Ivarsson ME, et al. Cell Chem Biol. 2019 Jan 17;26(1):17-26.e13. doi: 10.1016/j.chembiol.2018.10.002. Epub 2018 Oct 25. Cell Chem Biol. 2019. PMID: 30482680 Free article.

Symptoms associated with C. difficile infection (CDI) are mediated by secreted protein toxins, whose virulence is modulated by intracellular auto-proteolysis following allosteric activation of their protease domains by inositol hexakisphosphate (IP6). Here, we explo …

Symptoms associated with C. difficile infection (CDI) are mediated by secreted protein toxins, whose virulence is modulated by intracellular …

133

Effects of microbial phytase on mucin synthesis, gastric protein hydrolysis, and degradation of phytate along the gastrointestinal tract of growing pigs.

Mesina VGR, Lagos LV, Sulabo RC, Walk CL, Stein HH. Mesina VGR, et al. J Anim Sci. 2019 Feb 1;97(2):756-767. doi: 10.1093/jas/sky439. J Anim Sci. 2019. PMID: 30452657 Free PMC article.

Phytase did not affect mucin synthesis in the small intestine, protein hydrolysis in the stomach, or ileal digestibility of dispensable and indispensable AA. However, degradation of higher phytate esters (IP6 and IP5) into lower phytate esters (IP4 and IP3) and inositol …

Phytase did not affect mucin synthesis in the small intestine, protein hydrolysis in the stomach, or ileal digestibility of dispensable and …

134

IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating.

Dick RA, Mallery DL, Vogt VM, James LC. Dick RA, et al. Viruses. 2018 Nov 15;10(11):640. doi: 10.3390/v10110640. Viruses. 2018. PMID: 30445742 Free PMC article. Review.

Recent discoveries of positively-charged rings in the immature and mature protein hexamer subunits that comprise them and their binding to the cellular metabolite inositol hexakisphosphate (IP6) have stimulated exciting new hypotheses. In this paper, we discuss how …

Recent discoveries of positively-charged rings in the immature and mature protein hexamer subunits that comprise them and their binding to t …

135

Hydration mechanism of a calcium phosphate cement modified with phytic acid.

Hurle K, Weichhold J, Brueckner M, Gbureck U, Brueckner T, Goetz-Neunhoeffer F. Hurle K, et al. Acta Biomater. 2018 Oct 15;80:378-389. doi: 10.1016/j.actbio.2018.09.002. Epub 2018 Sep 6. Acta Biomater. 2018. PMID: 30195085

Calcium phosphate cements composed of beta-tricalcium phosphate (beta-TCP) and phosphoric acid were modified by addition of 5, 10, 12.5, 15 and 20 wt% phytic acid (IP6) related to the beta-TCP content and compared to a reference containing 0.5 M citric …

Calcium phosphate cements composed of beta-tricalcium phosphate (beta-TCP) and phosphoric acid were modified by addition of 5, 10, 12 …

136

Inositol hexaphosphate limits the migration and the invasiveness of colorectal carcinoma cells in vitro.

Schröterová L, Ježková A, Rudolf E, Caltová K, Králová V, Hanušová V. Schröterová L, et al. Int J Oncol. 2018 Oct;53(4):1625-1632. doi: 10.3892/ijo.2018.4488. Epub 2018 Jul 19. Int J Oncol. 2018. PMID: 30066850

Inositol hexaphosphate (IP6), also known as phytic acid, has been shown to exhibit anticancer effects in a number of preclinical tumor models. ...The present study attempted to characterize the effect of IP6 on the migration and adhesion …

Inositol hexaphosphate (IP6), also known as phytic acid, has been shown to exhibit anticancer effects in …

137

Phytate Decreases Formation of Advanced Glycation End-Products in Patients with Type II Diabetes: Randomized Crossover Trial.

Sanchis P, Rivera R, Berga F, Fortuny R, Adrover M, Costa-Bauza A, Grases F, Masmiquel L. Sanchis P, et al. Sci Rep. 2018 Jun 25;8(1):9619. doi: 10.1038/s41598-018-27853-9. Sci Rep. 2018. PMID: 29941991 Free PMC article. Clinical Trial.

Myo-inositol hexaphosphate (phytate; IP6) is a natural compound that is abundant in cereals, legumes, and nuts and it has the ability to chelate metal cations. ...Thus, we measured AGEs, glycated hemoglobin (HbA1c), several vascular risk factors, and urinary …

Myo-inositol hexaphosphate (phytate; IP6) is a natural compound that is abundant in cereals, legumes, and nuts and it h …

138

Structural and functional analysis of mRNA export regulation by the nuclear pore complex.

Lin DH, Correia AR, Cai SW, Huber FM, Jette CA, Hoelz A. Lin DH, et al. Nat Commun. 2018 Jun 13;9(1):2319. doi: 10.1038/s41467-018-04459-3. Nat Commun. 2018. PMID: 29899397 Free PMC article.

139

Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.

Gottlieb L, Marmorstein R. Gottlieb L, et al. Structure. 2018 Jul 3;26(7):925-935.e8. doi: 10.1016/j.str.2018.04.003. Epub 2018 May 10. Structure. 2018. PMID: 29754825 Free PMC article.

We demonstrate that hNatA contains unique features: a stabilizing inositol hexaphosphate (IP(6)) molecule and a metazoan-specific Naa15 domain that mediates high-affinity HYPK binding. ...

We demonstrate that hNatA contains unique features: a stabilizing inositol hexaphosphate (IP(6)) molecule and a metazoan-speci …

140

Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.

Okamura M, Yamanaka Y, Shigemoto M, Kitadani Y, Kobayashi Y, Kambe T, Nagao M, Kobayashi I, Okumura K, Masuda S. Okamura M, et al. PLoS One. 2018 May 10;13(5):e0197165. doi: 10.1371/journal.pone.0197165. eCollection 2018. PLoS One. 2018. PMID: 29746542 Free PMC article.

DBP5, also known as DDX19, GLE1 and inositol hexakisphosphate (IP6) function in messenger RNA (mRNA) export at the cytoplasmic surface of the nuclear pore complex in eukaryotic cells. DBP5 is a DEAD-box RNA helicase, and its activity is stimulated by interactions wi …

DBP5, also known as DDX19, GLE1 and inositol hexakisphosphate (IP6) function in messenger RNA (mRNA) export at the cytoplasmic …

141

Bioinspired Interfacial Chelating-like Reinforcement Strategy toward Mechanically Enhanced Lamellar Materials.

Chen K, Zhang S, Li A, Tang X, Li L, Guo L. Chen K, et al. ACS Nano. 2018 May 22;12(5):4269-4279. doi: 10.1021/acsnano.7b08671. Epub 2018 Apr 30. ACS Nano. 2018. PMID: 29697956

Herein, inspired by biologically strong chelating interactions of phytic acid (PA) or IP6 in many biomaterials, we present a biologically interfacial chelating-like reinforcement (BICR) strategy for fabrication of a highly dense ordered "brick-and-mortar" mic …

Herein, inspired by biologically strong chelating interactions of phytic acid (PA) or IP6 in many biomaterials, we pres …

142

3D powder printed tetracalcium phosphate scaffold with phytic acid binder: fabrication, microstructure and in situ X-Ray tomography analysis of compressive failure.

Mandal S, Meininger S, Gbureck U, Basu B. Mandal S, et al. J Mater Sci Mater Med. 2018 Mar 8;29(3):29. doi: 10.1007/s10856-018-6034-8. J Mater Sci Mater Med. 2018. PMID: 29520670

To this end, a new powder-binder combination, namely tetracalcium phosphate (TTCP) and phytic acid (IP6) was investigated at ambient temperature, for low load bearing application. ...

To this end, a new powder-binder combination, namely tetracalcium phosphate (TTCP) and phytic acid (IP6) was investigat …

143

Effect of phytase on growth performance, phytate degradation and gene expression of myo-inositol transporters in the small intestine, liver and kidney of 21 day old broilers.

Walk CL, Bedford MR, Olukosi OA. Walk CL, et al. Poult Sci. 2018 Apr 1;97(4):1155-1162. doi: 10.3382/ps/pex392. Poult Sci. 2018. PMID: 29444320 Free article.

Phytase supplementation increased gain (linear, P < 0.05). Phytate (iP6; quadratic, P < 0.05), phytate ester (iP5, iP4, iP3; quadratic, P < 0.05), and inositol (linear, P < 0.05) concentration in the gizzard was influenced by phytase supplementation. ...

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Phytase supplementation increased gain (linear, P < 0.05). Phytate (iP6; quadratic, P < 0.05), phytate ester (iP5, iP4, iP3; qu

…

144

Inositol polyphosphates contribute to cellular circadian rhythms: Implications for understanding lithium's molecular mechanism.

Wei H, Landgraf D, Wang G, McCarthy MJ. Wei H, et al. Cell Signal. 2018 Apr;44:82-91. doi: 10.1016/j.cellsig.2018.01.001. Epub 2018 Jan 11. Cell Signal. 2018. PMID: 29331582

We examined whether the signaling molecule inositol hexaphosphate (IP(6)) has effects on circadian rhythms. Using a bioluminescent reporter (Per2::luc) to measure circadian rhythms, we determined that IP(6) increased rhythm amplitude and shortened period in NIH3T3 c …

We examined whether the signaling molecule inositol hexaphosphate (IP(6)) has effects on circadian rhythms. Using a biolumines …

145

Inhibition of P-Glycoprotein Mediated Efflux in Caco-2 Cells by Phytic Acid.

Li L, Fu Q, Xia M, Xin L, Shen H, Li G, Ji G, Meng Q, Xie Y. Li L, et al. J Agric Food Chem. 2018 Jan 31;66(4):988-998. doi: 10.1021/acs.jafc.7b04307. Epub 2018 Jan 16. J Agric Food Chem. 2018. PMID: 29282978

Phytic acid (IP6) is a natural phosphorylated inositol, which is abundantly present in most cereal grains and seeds. ...In summary, IP6 is a promising P-gp inhibitor candidate....

Phytic acid (IP6) is a natural phosphorylated inositol, which is abundantly present in most cereal grains and se …

146

The Role of Arabidopsis Inositol Polyphosphate Kinase AtIPK2beta in Glucose Suppression of Seed Germination and Seedling Development.

Yang Q, Sang S, Chen Y, Wei Z, Wang P. Yang Q, et al. Plant Cell Physiol. 2018 Feb 1;59(2):343-354. doi: 10.1093/pcp/pcx186. Plant Cell Physiol. 2018. PMID: 29216370

In this study, we demonstrate that AtIPK2beta, known to participate in the synthesis of myo-inositol 1,2,3,4,5,6-hexakisphosphate (IP6, phytate), affects Arabidopsis responses to glucose during seed germination. ...Collectively, these findings indicate that AtIPK2be …

In this study, we demonstrate that AtIPK2beta, known to participate in the synthesis of myo-inositol 1,2,3,4,5,6-hexakisphosphate ( …

147

Structural basis of arrestin-3 activation and signaling.

Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM. Chen Q, et al. Nat Commun. 2017 Nov 10;8(1):1427. doi: 10.1038/s41467-017-01218-8. Nat Commun. 2017. PMID: 29127291 Free PMC article.

A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP(6)) is a non-receptor activator of arrestin-3 and report the structure of IP(6)-activated arrestin-3 at 2.4- …

A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that in …

148

Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway.

Kapral M, Wawszczyk J, Jesse K, Paul-Samojedny M, Kuśmierz D, Węglarz L. Kapral M, et al. Molecules. 2017 Oct 3;22(10):1657. doi: 10.3390/molecules22101657. Molecules. 2017. PMID: 28972559 Free PMC article.

Therefore, AKT/mTOR signaling pathway has been recognized as an attractive target for anticancer therapy. Inositol hexaphosphate (InsP6), a natural occurring phytochemical, has been shown to have both preventive and therapeutic effects against various cancers, howev …

Therefore, AKT/mTOR signaling pathway has been recognized as an attractive target for anticancer therapy. Inositol hexaphosphate …

149

Pancreatic and renal function in streptozotocin-induced type 2 diabetic rats administered combined inositol hexakisphosphate and inositol supplement.

Foster SR, Dilworth LL, Omoruyi FO, Thompson R, Alexander-Lindo RL. Foster SR, et al. Biomed Pharmacother. 2017 Dec;96:72-77. doi: 10.1016/j.biopha.2017.09.126. Epub 2017 Sep 28. Biomed Pharmacother. 2017. PMID: 28965010

Examination of H&E stained pancreatic sections showed a significant increase (107%) in the number of islets in the combined IP6 and inositol treated group compared to the untreated diabetic group. Overall, the treatment of type 2 diabetic rats with combined I …

Examination of H&E stained pancreatic sections showed a significant increase (107%) in the number of islets in the combined IP6 a …

150

Impacts of dietary calcium, phytate, and phytase on inositol hexakisphosphate degradation and inositol phosphate release in different segments of digestive tract of broilers.

Li W, Angel R, Kim SW, Brady K, Yu S, Plumstead PW. Li W, et al. Poult Sci. 2017 Oct 1;96(10):3626-3637. doi: 10.3382/ps/pex170. Poult Sci. 2017. PMID: 28938789 Free PMC article.

Concentrations of IP3-6 in the crop, proventriculus (Prov) plus (+) gizzard (Giz), and distal ileum, as well as the ileal IP6 and P disappearance were determined at 13 d of age. The detrimental impact of Ca on IP6 and P disappearance was observed only in the ileum, …

Concentrations of IP3-6 in the crop, proventriculus (Prov) plus (+) gizzard (Giz), and distal ileum, as well as the ileal IP6 and P d …

151

Inositol Hexakis Phosphate is the Seasonal Phosphorus Reservoir in the Deciduous Woody Plant Populus alba L.

Kurita Y, Baba K, Ohnishi M, Matsubara R, Kosuge K, Anegawa A, Shichijo C, Ishizaki K, Kaneko Y, Hayashi M, Suzaki T, Fukaki H, Mimura T. Kurita Y, et al. Plant Cell Physiol. 2017 Sep 1;58(9):1477-1485. doi: 10.1093/pcp/pcx106. Plant Cell Physiol. 2017. PMID: 28922751

.), organic phosphates are accumulated in twigs from late summer to winter, and that IP6 (myo-inositol-1,2,3,4,5,6-hexakis phosphate: phytic acid) is the primary storage form. IP6 was found in high concentrations in twigs during winter and quick …

.), organic phosphates are accumulated in twigs from late summer to winter, and that IP6 (myo-inositol-1,2,3,4,5,6-hexakis pho …

152

Inositol hexaphosphate hydrolysate competitively binds to AKT to inhibit the proliferation of colon carcinoma.

Chen C, Yang F, Liu C, Cui L, Fu M, Song Y. Chen C, et al. Oncol Rep. 2017 Nov;38(5):2901-2910. doi: 10.3892/or.2017.5943. Epub 2017 Sep 7. Oncol Rep. 2017. PMID: 28901472

Phytate, myto-inositol 1,2,3,4,5,6 hexaphosphate (IP6), is recognized as an anti-nutrition phytochemical for decades. Recently, numerous studies have indicated that IP6 and its hydrolysates could suppress colon oncogenesis. However, very little is know …

Phytate, myto-inositol 1,2,3,4,5,6 hexaphosphate (IP6), is recognized as an anti-nutrition phytochemical for decades. R …

153

Nup42 and IP₆ coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells.

Adams RL, Mason AC, Glass L, Aditi, Wente SR. Adams RL, et al. Traffic. 2017 Dec;18(12):776-790. doi: 10.1111/tra.12526. Epub 2017 Oct 16. Traffic. 2017. PMID: 28869701 Free PMC article.

As mRNPs exit the nuclear pore complex (NPC) in Saccharomyces cerevisiae, this remodeling occurs through activation of Dbp5 by inositol hexakisphosphate (IP(6) )-bound Gle1. At the NPC, Gle1 also binds Nup42, but Nup42's molecular function is unclear. ...

As mRNPs exit the nuclear pore complex (NPC) in Saccharomyces cerevisiae, this remodeling occurs through activation of Dbp5 by inositol …

154

Effects of Adding Polysaccharides and Citric Acid into Sodium Dihydrogen Phosphate Mixing Solution on the Material Properties of Gelatin-Hybridized Calcium-Phosphate Cement.

Kiminami K, Konishi T, Mizumoto M, Nagata K, Honda M, Arimura H, Aizawa M. Kiminami K, et al. Materials (Basel). 2017 Aug 12;10(8):941. doi: 10.3390/ma10080941. Materials (Basel). 2017. PMID: 28805704 Free PMC article.

We have succeeded in improving the material properties of a chelate-setting calcium-phosphate cement (CPC), which is composed of hydroxyapatite (HAp) the surface of which has been modified with inositol hexaphosphate (IP6) by adding alpha-tricalcium phosphate …

We have succeeded in improving the material properties of a chelate-setting calcium-phosphate cement (CPC), which is composed of hydroxyapat …

155

Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathways in colon cancer cells.

Kapral M, Wawszczyk J, Sośnicki S, Jesse K, Węglarz L. Kapral M, et al. Prostaglandins Other Lipid Mediat. 2017 Jul;131:41-48. doi: 10.1016/j.prostaglandins.2017.08.002. Epub 2017 Aug 8. Prostaglandins Other Lipid Mediat. 2017. PMID: 28797636

Cyclooxygenase (COX) and lipoxygenase (LOX) are key enzymes of arachidonic acid metabolism. Their products, prostaglandins and leukotrienes, are involved in the pathogenesis of inflammatory bowel diseases and colorectal cancer. The aim of the study was to examine the influ …

Cyclooxygenase (COX) and lipoxygenase (LOX) are key enzymes of arachidonic acid metabolism. Their products, prostaglandins and leukot …

156

The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes.

Cordeiro CD, Saiardi A, Docampo R. Cordeiro CD, et al. Mol Microbiol. 2017 Oct;106(2):319-333. doi: 10.1111/mmi.13766. Epub 2017 Aug 22. Mol Microbiol. 2017. PMID: 28792096 Free PMC article.

Here, we report the correct identification and characterization of the kinases involved in the inositol pyrophosphate biosynthetic pathway in Trypanosoma brucei: inositol polyphosphate multikinase (TbIPMK), inositol pentakisphosphate 2-kinase (TbIP5K) and …

Here, we report the correct identification and characterization of the kinases involved in the inositol pyrophosphate biosynthetic pa …

157

Effects of combined inositol hexakisphosphate and inositol supplement on antioxidant activity and metabolic enzymes in the liver of streptozotocin-induced type 2 diabetic rats.

Foster SR, Dilworth LL, Thompson RK, Alexander-Lindo RL, Omoruyi FO. Foster SR, et al. Chem Biol Interact. 2017 Sep 25;275:108-115. doi: 10.1016/j.cbi.2017.07.024. Epub 2017 Jul 28. Chem Biol Interact. 2017. PMID: 28757134

Diabetes mellitus is associated with elevated reactive oxygen species, lipid abnormalities, reduced antioxidant activity and organ damage. This study examines the effects of combined inositol hexakisphosphate (IP6) and inositol supplement on antioxidant level …

Diabetes mellitus is associated with elevated reactive oxygen species, lipid abnormalities, reduced antioxidant activity and organ damage. T …

158

High-resolution mass spectrometric analysis of myo-inositol hexakisphosphate using electrospray ionisation Orbitrap.

McIntyre CA, Arthur CJ, Evershed RP. McIntyre CA, et al. Rapid Commun Mass Spectrom. 2017 Oct 30;31(20):1681-1689. doi: 10.1002/rcm.7935. Rapid Commun Mass Spectrom. 2017. PMID: 28696018 Free PMC article.

RATIONALE: The phosphorus storage compound in grains, phytic acid, or myo-inositol hexakisphosphate (IP6), is important for nutrition and human health, and is reportedly the most abundant organic phosphorus compound in soils. ...Further evidence for di …

RATIONALE: The phosphorus storage compound in grains, phytic acid, or myo-inositol hexakisphosphate (IP6), is im …

159

Enhanced Fenton-like degradation of TCE in sand suspensions with magnetite by NTA/EDTA at circumneutral pH.

Wang N, Jia D, Jin Y, Sun SP, Ke Q. Wang N, et al. Environ Sci Pollut Res Int. 2017 Jul;24(21):17598-17605. doi: 10.1007/s11356-017-9387-5. Epub 2017 Jun 8. Environ Sci Pollut Res Int. 2017. PMID: 28597389

The present study investigated the degradation of trichloroethylene (TCE) in sand suspensions by Fenton-like reaction with magnetite (Fe(3)O(4)) in the presence of various chelators at circumneutral pH. The results showed that ethylenediaminetetraacetic acid (EDTA) and nit …

The present study investigated the degradation of trichloroethylene (TCE) in sand suspensions by Fenton-like reaction with magnetite (Fe(3)O …

160

Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase.

Franco-Echevarría E, Sanz-Aparicio J, Troffer-Charlier N, Poterszman A, González B. Franco-Echevarría E, et al. Protein J. 2017 Aug;36(4):240-248. doi: 10.1007/s10930-017-9717-y. Protein J. 2017. PMID: 28429156

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) is an enzyme that catalyses the formation of phytic acid (IP(6)) from IP(5) and ATP. In mammals, IP(6) is involved in multiple events such as DNA repair and mRNA edit and it is the precursor of inos …

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) is an enzyme that catalyses the formation of phytic acid (IP( …

161

Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis.

Ren L, Hong ES, Mendoza A, Issaq S, Tran Hoang C, Lizardo M, LeBlanc A, Khanna C. Ren L, et al. Oncotarget. 2017 Jun 13;8(24):38541-38553. doi: 10.18632/oncotarget.15872. Oncotarget. 2017. PMID: 28404949 Free PMC article.

By comparing the identity and level of the metabolites between high/low metastatic cells, several metabolic pathways were identified to be differentially activated, such as arginine, glutathione, inositol and fatty acid metabolic pathways. To further interrogate the …

By comparing the identity and level of the metabolites between high/low metastatic cells, several metabolic pathways were identified to be d …

162

Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.

Yu W, Liu C, Li X, Yang F, Cheng L, Liu C, Song Y. Yu W, et al. Eur J Pharmacol. 2017 Jun 15;805:67-74. doi: 10.1016/j.ejphar.2017.03.011. Epub 2017 Mar 15. Eur J Pharmacol. 2017. PMID: 28315345

Colorectal cancer (CRC) is common worldwide, and most treatments for CRC have undesirable side effects. Many researchers have demonstrated that inositol hexaphosphate (IP6) has potent anticarcinogenic activity against CRC and no apparent toxicity to normal ce …

Colorectal cancer (CRC) is common worldwide, and most treatments for CRC have undesirable side effects. Many researchers have demonstrated t …

163

Complexes of myo-Inositol-Hexakisphosphate (IP6) with Zinc or Lanthanum for the Decorporation of Radiocesium.

Ogawa K, Aoki M, Fukuda T, Kadono S, Kiwada T, Odani A. Ogawa K, et al. Chem Pharm Bull (Tokyo). 2017;65(3):261-267. doi: 10.1248/cpb.c16-00792. Chem Pharm Bull (Tokyo). 2017. PMID: 28250348 Free article.

In vitro binding assays indicated that La-IP6 and Zn-IP6 complexes adsorbed (137)Cs, with the adsorption capacity of Zn-IP6 to (137)Cs greater than that of La-IP6. To evaluate the usefulness of La-IP6 and Zn-IP6 in vivo, La-IP6 or …

In vitro binding assays indicated that La-IP6 and Zn-IP6 complexes adsorbed (137)Cs, with the adsorption capacity of Zn-IP6 …

164

Hydrolysis of phytate to its lower esters can influence the growth performance and nutrient utilization of broilers with regular or super doses of phytase.

Beeson LA, Walk CL, Bedford MR, Olukosi OA. Beeson LA, et al. Poult Sci. 2017 Jul 1;96(7):2243-2253. doi: 10.3382/ps/pex012. Poult Sci. 2017. PMID: 28204754 Free PMC article.

Phytase linearly increased copper (P < 0.001) and linearly decreased Ca (P < 0.05) utilization in the ileum. Phytase decreased ileal (IPx, inositol x-phosphate) IP6 and IP5 and increased inositol (quadratic, P < 0.001) but had no effect on IP4 or IP3

…

Phytase linearly increased copper (P < 0.001) and linearly decreased Ca (P < 0.05) utilization in the ileum. Phytase decreased ileal (

…

165

Colloidal Vesicular System of Inositol Hexaphosphate to Counteract DMBA Induced Dysregulation of Markers Pertaining to Cellular Proliferation/Differentiation and Inflammation of Epidermal Layer in Mouse Model.

Arya M, Tiwari P, Tripathi CB, Parashar P, Singh M, Sinha P, Yadav NP, Kaithwas G, Gupta KP, Saraf SA. Arya M, et al. Mol Pharm. 2017 Mar 6;14(3):928-939. doi: 10.1021/acs.molpharmaceut.6b01147. Epub 2017 Feb 16. Mol Pharm. 2017. PMID: 28169546

Cancer is a global health problem and chemoprevention is a promising approach for reducing cancer burden. Inositol hexaphosphate (IP6), a natural bioactive constituent of cereals, legumes, etc., has momentous potential as an antiangiogenic agent, that specifi …

Cancer is a global health problem and chemoprevention is a promising approach for reducing cancer burden. Inositol hexaphosphate …

166

Inositol hexa phosphoric acid (phytic acid), a nutraceuticals, attenuates iron-induced oxidative stress and alleviates liver injury in iron overloaded mice.

Bhowmik A, Ojha D, Goswami D, Das R, Chandra NS, Chatterjee TK, Chakravarty A, Chakravarty S, Chattopadhyay D. Bhowmik A, et al. Biomed Pharmacother. 2017 Mar;87:443-450. doi: 10.1016/j.biopha.2016.12.125. Epub 2017 Jan 6. Biomed Pharmacother. 2017. PMID: 28068635

Inositol hexa phosphoric acid (IP6) or Phytic acid, a natural antioxidant of some leguminous plants, known to act as a protective agent for seed storage in plants by suppressing iron catalyzed oxidative process. ...Oral administration of IP6 …

Inositol hexa phosphoric acid (IP6) or Phytic acid, a natural antioxidant of some leguminous plants, know …

167

Fast determination of bioactive phytic acid and pyrophosphate in walnuts using microwave accelerated extraction.

Liu T, He L, Valiente M, López-Mesas M. Liu T, et al. Food Chem. 2017 Apr 15;221:771-775. doi: 10.1016/j.foodchem.2016.11.105. Epub 2016 Nov 23. Food Chem. 2017. PMID: 27979271

Bioactive compounds phytic acid (IP6) and pyrophosphate (PPi) are minor components of walnuts with the ability of being inhibitors of urolithiasis, among others. ...The possible hydrolysis of phytic acid by MAE was analyzed. Compared with the co …

Bioactive compounds phytic acid (IP6) and pyrophosphate (PPi) are minor components of walnuts with the ability of being …

168

The effect of combined inositol hexakisphosphate and inositol supplement in streptozotocin-induced type 2 diabetic rats.

Foster SR, Omoruyi FO, Bustamante J, Lindo RL, Dilworth LL. Foster SR, et al. Int J Exp Pathol. 2016 Oct;97(5):397-407. doi: 10.1111/iep.12210. Epub 2016 Dec 6. Int J Exp Pathol. 2016. PMID: 27921351 Free PMC article.

Inositol hexakisphosphate (IP6) and inositol both regulate insulin secretion, but their combined use in the management of diabetes deserves investigation. The combined effects of IP6 and inositol supplementation were investigated in streptozotoc …

Inositol hexakisphosphate (IP6) and inositol both regulate insulin secretion, but their combined use in the management …

169

Effect of phytic acid etchant on resin-dentin bonding: Monomer penetration and stability of dentin collagen.

Kong K, Hiraishi N, Nassar M, Otsuki M, Yiu CKY, Tagami J. Kong K, et al. J Prosthodont Res. 2017 Jul;61(3):251-258. doi: 10.1016/j.jpor.2016.10.001. Epub 2016 Oct 21. J Prosthodont Res. 2017. PMID: 27777071

PURPOSE: Phytic acid (IP6) works well as an etchant in dentin bonding to remove the smear layer due to its acidity and chelating effect. This study compared the etching effect of IP6 with phosphoric acid (PA) and ethylenediaminetetraacetic ac …

PURPOSE: Phytic acid (IP6) works well as an etchant in dentin bonding to remove the smear layer due to its acidity and …

170

Effect of popping and fermentation on proximate composition, minerals and absorption inhibitors, and mineral bioavailability of Amaranthus caudatus grain cultivated in Ethiopia.

Amare E, Mouquet-Rivier C, Rochette I, Adish A, Haki GD. Amare E, et al. J Food Sci Technol. 2016 Jul;53(7):2987-2994. doi: 10.1007/s13197-016-2266-0. Epub 2016 Jul 13. J Food Sci Technol. 2016. PMID: 27765968 Free PMC article.

While fermentation increased protein, fat and ash content by 3, 22 and 14 %, respectively but did not significantly change ADF and NDF content. Fe, Ca and phytic acid (IP6) decreased during popping but Mg, Zn, galloyl and catechol did not change significantly …

While fermentation increased protein, fat and ash content by 3, 22 and 14 %, respectively but did not significantly change ADF and NDF conte …

171

Methodology affects measures of phosphorus availability in growing broilers. 2. Effects of calcium feeding strategy and dietary adaptation period length on phytate hydrolysis at different locations in the gastrointestinal tract1.

Perryman KR, Masey O'Neill HV, Bedford MR, Dozier WA 3rd. Perryman KR, et al. Poult Sci. 2017 Mar 1;96(3):622-633. doi: 10.3382/ps/pew292. Poult Sci. 2017. PMID: 27601686 Free article.

An experiment was conducted to determine the effects of dietary adaptation period length (DAPL; 0, 24, and 48 h) and Ca feeding strategy (0.35% or 1.4:1 Ca:P ratio) on apparent phytate P (myo-inositol 1,2,3,4,5,6 hexakis dihydrogen phosphate; IP6) hydrolysis (AIP6H) …

An experiment was conducted to determine the effects of dietary adaptation period length (DAPL; 0, 24, and 48 h) and Ca feeding strategy (0. …

172

Methodology affects measures of phosphorus availability in growing broilers: Effects of calcium feeding strategy and dietary adaptation period length on true ileal phosphorus digestibility and predicted endogenous phosphorus losses1.

Perryman KR, Masey O'Neill HV, Bedford MR, Dozier WA 3rd. Perryman KR, et al. Poult Sci. 2017 Mar 1;96(3):611-621. doi: 10.3382/ps/pew291. Poult Sci. 2017. PMID: 27591272 Free article.

An experiment was conducted to determine the effects of Ca feeding strategy and dietary adaptation period length (DAPL) on the apparent ileal P digestibility (AIPD) and apparent ileal myo-inositol 1,2,3,4,5,6 hexakis dihydrogen phosphate (IP6) hydrolysis (AIIP6H) of …

An experiment was conducted to determine the effects of Ca feeding strategy and dietary adaptation period length (DAPL) on the apparent ilea …

173

Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family.

Zhang ZM, Ma KW, Yuan S, Luo Y, Jiang S, Hawara E, Pan S, Ma W, Song J. Zhang ZM, et al. Nat Struct Mol Biol. 2016 Sep;23(9):847-52. doi: 10.1038/nsmb.3279. Epub 2016 Aug 15. Nat Struct Mol Biol. 2016. PMID: 27525589

Here, we report the crystal structures of the YopJ effector HopZ1a, produced by the phytopathogen Pseudomonas syringae, in complex with the eukaryote-specific cofactor inositol hexakisphosphate (IP6) and/or coenzyme A (CoA). Structural, computational and functional …

Here, we report the crystal structures of the YopJ effector HopZ1a, produced by the phytopathogen Pseudomonas syringae, in complex with the …

174

Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems.

Silva EO, Bracarense AP. Silva EO, et al. J Food Sci. 2016 Jun;81(6):R1357-62. doi: 10.1111/1750-3841.13320. Epub 2016 May 3. J Food Sci. 2016. PMID: 27272247 Review.

Several studies have shown the benefits of natural antioxidants on health and food preservation. Phytic acid (IP6) is a natural antioxidant that is found mainly in cereals and vegetables and, for a long period of time, was considered an antinutritional factor …

Several studies have shown the benefits of natural antioxidants on health and food preservation. Phytic acid (IP6) is a …

175

Synergy and antagonism in regulation of recombinant human INO80 chromatin remodeling complex.

Willhoft O, Bythell-Douglas R, McCormack EA, Wigley DB. Willhoft O, et al. Nucleic Acids Res. 2016 Sep 30;44(17):8179-88. doi: 10.1093/nar/gkw509. Epub 2016 Jun 2. Nucleic Acids Res. 2016. PMID: 27257055 Free PMC article.

This core complex has nucleosome sliding activity that is similar to that of endogenous human and yeast Ino80 complexes and is also inhibited by inositol hexaphosphate (IP6). We show that IP6 is a non-competitive inhibitor that acts by blocking the sti …

This core complex has nucleosome sliding activity that is similar to that of endogenous human and yeast Ino80 complexes and is also inhibite …

176

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice.

Fu M, Song Y, Wen Z, Lu X, Cui L. Fu M, et al. Nutrients. 2016 May 12;8(5):286. doi: 10.3390/nu8050286. Nutrients. 2016. PMID: 27187454 Free PMC article.

Inositol hexaphosphate (IP6) and inositol (Ins), naturally occurring carbohydrates present in most mammals and plants, inhibit the growth of numerous cancers both in vitro and in vivo. ...CT-26 cells were injected into the splenic capsule of 48 BALB/c …

Inositol hexaphosphate (IP6) and inositol (Ins), naturally occurring carbohydrates present in most mammals and p …

177

The effect of inositol hexaphosphate on cadmium sorption to gibbsite.

Ruyter-Hooley M, Larsson AC, Johnson BB, Antzutkin ON, Angove MJ. Ruyter-Hooley M, et al. J Colloid Interface Sci. 2016 Jul 15;474:159-70. doi: 10.1016/j.jcis.2016.04.028. Epub 2016 Apr 20. J Colloid Interface Sci. 2016. PMID: 27124810

The presence of complexing anions is also known to affect the binding of these metals in soils. Since organophosphates, such as inositol hexaphosphate (IP6), are present in most soil systems they are expected to affect the nature of the interaction between me …

The presence of complexing anions is also known to affect the binding of these metals in soils. Since organophosphates, such as inositol …

178

Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti-O-P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion.

Córdoba A, Hierro-Oliva M, Pacha-Olivenza MÁ, Fernández-Calderón MC, Perelló J, Isern B, González-Martín ML, Monjo M, Ramis JM. Córdoba A, et al. ACS Appl Mater Interfaces. 2016 May 11;8(18):11326-35. doi: 10.1021/acsami.6b02533. Epub 2016 Apr 27. ACS Appl Mater Interfaces. 2016. PMID: 27088315

Myo-inositol hexaphosphate, also called phytic acid or phytate (IP6), is a natural molecule abundant in vegetable seeds and legumes. ...We present here a method to directly functionalize Ti surfaces covalently with IP6, without using a cr …

Myo-inositol hexaphosphate, also called phytic acid or phytate (IP6), is a natural molecule abundant in v …

179

Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.

Li C, Lev S, Saiardi A, Desmarini D, Sorrell TC, Djordjevic JT. Li C, et al. Sci Rep. 2016 Apr 1;6:23927. doi: 10.1038/srep23927. Sci Rep. 2016. PMID: 27033523 Free PMC article.

Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP6 to PP-IP5/IP7, but the kinase converting IP5 to IP …

Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is ess …

180

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

Scherer PC, Ding Y, Liu Z, Xu J, Mao H, Barrow JC, Wei N, Zheng N, Snyder SH, Rao F. Scherer PC, et al. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3503-8. doi: 10.1073/pnas.1525580113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976604 Free PMC article.

We now report that inositol hexakisphosphate (IP6) is a major physiologic determinant of the CRL-CSN interface, which includes a hitherto unidentified electrostatic interaction between the N-terminal acidic tail of CSN subunit 2 (CSN2) and a conserved basic canyon o …

We now report that inositol hexakisphosphate (IP6) is a major physiologic determinant of the CRL-CSN interface, which includes …

181

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.

Ouyang Z, Zheng G, Tomchick DR, Luo X, Yu H. Ouyang Z, et al. Mol Cell. 2016 Apr 21;62(2):248-259. doi: 10.1016/j.molcel.2016.02.033. Epub 2016 Mar 10. Mol Cell. 2016. PMID: 26971492 Free PMC article.

Our structure establishes the basis for how Wapl and Sororin antagonistically influence cohesin dynamics. The structure further reveals that Pds5 can bind inositol hexakisphosphate (IP6). The IP6-binding segment of Pds5B is shaped like the jaw of a plier leve …

Our structure establishes the basis for how Wapl and Sororin antagonistically influence cohesin dynamics. The structure further reveals that …

182

Analysis of weighted co-regulatory networks in maize provides insights into new genes and regulatory mechanisms related to inositol phosphate metabolism.

Zhang S, Yang W, Zhao Q, Zhou X, Jiang L, Ma S, Liu X, Li Y, Zhang C, Fan Y, Chen R. Zhang S, et al. BMC Genomics. 2016 Feb 24;17:129. doi: 10.1186/s12864-016-2476-x. BMC Genomics. 2016. PMID: 26911482 Free PMC article.

BACKGROUND: D-myo-inositol phosphates (IPs) are a series of phosphate esters. Myo-inositol hexakisphosphate (phytic acid, IP6) is the most abundant IP and has negative effects on animal and human nutrition. ...However, the metabolic pathways and …

BACKGROUND: D-myo-inositol phosphates (IPs) are a series of phosphate esters. Myo-inositol hexakisphosphate (phytic …

183

Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.

Yin MX, Catimel B, Gregory M, Condron M, Kapp E, Holmes AB, Burgess AW. Yin MX, et al. Integr Biol (Camb). 2016 Mar 14;8(3):309-18. doi: 10.1039/c5ib00264h. Integr Biol (Camb). 2016. PMID: 26840369

Inositol hexakisphosphate (InsP6 or IP6) is an important signalling molecule in vesicular trafficking, neurotransmission, immune responses, regulation of protein kinases and phosphatases, activation of ion channels, antioxidant functions and anticancer activities. A …

Inositol hexakisphosphate (InsP6 or IP6) is an important signalling molecule in vesicular trafficking, neurotransmission, immu …

184

An amyotrophic lateral sclerosis-linked mutation in GLE1 alters the cellular pool of human Gle1 functional isoforms.

Aditi, Glass L, Dawson TR, Wente SR. Aditi, et al. Adv Biol Regul. 2016 Sep;62:25-36. doi: 10.1016/j.jbior.2015.11.001. Epub 2015 Nov 11. Adv Biol Regul. 2016. PMID: 26776475 Free PMC article.

In prior studies, two deleterious heterozygous mutations in the gene encoding human (h)Gle1 were identified in ALS patients. hGle1 is an mRNA processing modulator that requires inositol hexakisphosphate (IP(6)) binding for function. Interestingly, one hGLE1 mutation (c.196 …

In prior studies, two deleterious heterozygous mutations in the gene encoding human (h)Gle1 were identified in ALS patients. hGle1 is an mRN …

185

Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and alpha-synuclein aggregation in 6-OHDA induced parkinson's disease cell model.

Zhang Z, Hou L, Li X, Ju C, Zhang J, Li X, Wang X, Liu C, Lv Y, Wang Y. Zhang Z, et al. Brain Res. 2016 Feb 15;1633:87-95. doi: 10.1016/j.brainres.2015.12.035. Epub 2015 Dec 29. Brain Res. 2016. PMID: 26740400

Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydop …

Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease ( …

186

Impacts of dietary calcium, phytate, and nonphytate phosphorus concentrations in the presence or absence of phytase on inositol hexakisphosphate (IP6) degradation in different segments of broilers digestive tract.

Li W, Angel R, Kim SW, Brady K, Yu S, Plumstead PW. Li W, et al. Poult Sci. 2016 Mar;95(3):581-9. doi: 10.3382/ps/pev354. Epub 2016 Jan 6. Poult Sci. 2016. PMID: 26740131 Free PMC article.

A total of 1,440 straight-run Heritage 56M fast-feathering Cobb 500F broiler birds were fed from 11 to 13 d of age to determine the impacts of calcium (Ca), phytate phosphorus (PP), nonphytate P (NPP) and phytase concentrations on the myo-inositol hexakisphosphate (IP6 …

A total of 1,440 straight-run Heritage 56M fast-feathering Cobb 500F broiler birds were fed from 11 to 13 d of age to determine the impacts …

187

ANTIPROLIFERATIVE EFFECT OF INOSITOL HEXAPHOSPHATE ON HUMAN SKIN MELANOMA CELLS IN VITRO.

Wawszczyk J, Kapral M, Lodowska J, Jesse K, Hollek A, Węglarz L. Wawszczyk J, et al. Acta Pol Pharm. 2015 Sep-Oct;72(5):895-900. Acta Pol Pharm. 2015. PMID: 26665395 Free article.

In recent years, the interest in plants and their biologically active constituents as a source of novel potential drugs significantly increased. Inositol hexaphosphate (IP6) is a naturally occurring compound that has been shown to inhibit the growth of a wide …

In recent years, the interest in plants and their biologically active constituents as a source of novel potential drugs significantly increa …

188

DOWN-REGULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION BY INOSITOL HEXAPHOSPHATE IN HUMAN COLON CANCER CELLS.

Kapral M, Wawszczyk J, Sośnicki S, Węglarz L. Kapral M, et al. Acta Pol Pharm. 2015 Jul-Aug;72(4):705-11. Acta Pol Pharm. 2015. PMID: 26647627 Free article.

A selective inhibitors of iNOS could be, therefore, considered to be good candidates as chemopreventive agents against colon cancer. In this study, the effect of inositol hexaphosphate (IP6), dietary phytochemical, on the mRNA expression of iNOS stimulated wi …

A selective inhibitors of iNOS could be, therefore, considered to be good candidates as chemopreventive agents against colon cancer. In this …

189

Enteric-coated tablet of risedronate sodium in combination with phytic acid, a natural chelating agent, for improved oral bioavailability.

Kim JS, Jang SW, Son M, Kim BM, Kang MJ. Kim JS, et al. Eur J Pharm Sci. 2016 Jan 20;82:45-51. doi: 10.1016/j.ejps.2015.11.011. Epub 2015 Dec 1. Eur J Pharm Sci. 2016. PMID: 26594027

In the present study, to increase oral BA of the bisphosphonate, a novel enteric-coated tablet (ECT) dosage form of RS in combination with phytic acid (IP6), a natural chelating agent recognized as safe, was formulated. The chelating behavior of IP6 ag …

In the present study, to increase oral BA of the bisphosphonate, a novel enteric-coated tablet (ECT) dosage form of RS in combination with …

190

Conundrum of IP6.

Vucenik I. Vucenik I. Open Biol. 2015 Nov;5(11):150048. doi: 10.1098/rsob.150048. Open Biol. 2015. PMID: 26581571 Free PMC article.

Here are comments on the recent paper on the determination of inositol hexaphosphate (IP6) in human plasma and on its efficacy....

Here are comments on the recent paper on the determination of inositol hexaphosphate (IP6) in human plasma and on its e …

191

Synthesis of Biotinylated Inositol Hexakisphosphate To Study DNA Double-Strand Break Repair and Affinity Capture of IP6-Binding Proteins.

Jiao C, Summerlin M, Bruzik KS, Hanakahi L. Jiao C, et al. Biochemistry. 2015 Oct 20;54(41):6312-22. doi: 10.1021/acs.biochem.5b00642. Epub 2015 Oct 7. Biochemistry. 2015. PMID: 26397942

Inositol hexakisphosphate (IP6) is a soluble inositol polyphosphate, which is abundant in mammalian cells. ...We report on the synthesis, characterization, and application of biotin-labeled IP6 (IP6-biotin), which has biotin attached at position …

Inositol hexakisphosphate (IP6) is a soluble inositol polyphosphate, which is abundant in mammalian cells. ...We report …

192

How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy.

Brewster MS, Gaudet R. Brewster MS, et al. Bioessays. 2015 Nov;37(11):1184-92. doi: 10.1002/bies.201500085. Epub 2015 Sep 21. Bioessays. 2015. PMID: 26387779 Free PMC article. Review.

Unexpected structural features include a TRP-domain helix similar to TRPV1, a novel ligand-binding site, and an unusual C-terminal coiled coil stabilized by inositol hexakisphosphate (IP6). TRP-domain helices, which structurally act as a nexus for communication betw …

Unexpected structural features include a TRP-domain helix similar to TRPV1, a novel ligand-binding site, and an unusual C-terminal coiled co …

193

The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism.

Fu Q, Wang H, Xia M, Deng B, Shen H, Ji G, Li G, Xie Y. Fu Q, et al. Eur J Pharm Sci. 2015 Dec 1;80:1-8. doi: 10.1016/j.ejps.2015.09.009. Epub 2015 Sep 15. Eur J Pharm Sci. 2015. PMID: 26385515

This study investigated the effect of phytic acid (IP6), a potential absorption enhancer of flavonoid components, on tight junction (TJ) integrity in Caco-2 cell monolayers and its possible mechanisms. ...The present work will offer some useful guidance for t …

This study investigated the effect of phytic acid (IP6), a potential absorption enhancer of flavonoid components, on ti …

194

Two serine residues in Pseudomonas syringae effector HopZ1a are required for acetyltransferase activity and association with the host co-factor.

Ma KW, Jiang S, Hawara E, Lee D, Pan S, Coaker G, Song J, Ma W. Ma KW, et al. New Phytol. 2015 Dec;208(4):1157-68. doi: 10.1111/nph.13528. Epub 2015 Jun 23. New Phytol. 2015. PMID: 26103463 Free PMC article.

Using proton nuclear magnetic resonance (NMR), we observed a conformational change of HopZ1a in the presence of inositol hexakisphosphate (IP6), which acts as a eukaryotic co-factor and significantly enhances the acetyltransferase activity of several YopJ family eff …

Using proton nuclear magnetic resonance (NMR), we observed a conformational change of HopZ1a in the presence of inositol hexakisphosp …

195

Optimized core-shell Au@Ag nanoparticles for label-free Raman determination of trace Rhodamine B with cancer risk in food product.

Wang H, Guo X, Fu S, Yang T, Wen Y, Yang H. Wang H, et al. Food Chem. 2015 Dec 1;188:137-42. doi: 10.1016/j.foodchem.2015.04.122. Epub 2015 Apr 30. Food Chem. 2015. PMID: 26041175

A simple and reliable method based on surface-enhanced Raman scattering (SERS) with a portable Raman system is described for sensitive determination of trace levels of Rhodamine B (RB) in hot sauce samples. The sodium salt of phytic acid (IP6) stabilized Au@A …

A simple and reliable method based on surface-enhanced Raman scattering (SERS) with a portable Raman system is described for sensitive deter …

196

Enhanced secretion of natto phytase by Bacillus subtilis.

Tsuji S, Tanaka K, Takenaka S, Yoshida K. Tsuji S, et al. Biosci Biotechnol Biochem. 2015;79(11):1906-14. doi: 10.1080/09168451.2015.1046366. Epub 2015 May 29. Biosci Biotechnol Biochem. 2015. PMID: 26023739

Phytases comprise a group of phosphatases that trim inorganic phosphates from phytic acid (IP6). In this study, we aimed to achieve the efficient secretion of phytase by Bacillus subtilis. ...Thus, the secreted natto phytase was purified and found to remove u …

Phytases comprise a group of phosphatases that trim inorganic phosphates from phytic acid (IP6). In this study, we aime …

197

Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target.

Liu G, Song Y, Cui L, Wen Z, Lu X. Liu G, et al. Int J Clin Exp Pathol. 2015 Feb 1;8(2):1402-10. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 25973024 Free PMC article.

BACKGROUND: Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in high amounts in almost all plants and mammalian cells. ...IP6 induced apoptosis in HT-29 cells in a dose-dependent manner. ...

BACKGROUND: Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in high amounts in almost …

198

Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding.

Kong K, Islam MS, Nassar M, Hiraishi N, Otsuki M, Yiu CKY, Tagami J. Kong K, et al. J Mech Behav Biomed Mater. 2015 Aug;48:145-152. doi: 10.1016/j.jmbbm.2015.03.027. Epub 2015 Apr 6. J Mech Behav Biomed Mater. 2015. PMID: 25933170

OBJECTIVE: This study examined the effect of phytic acid (IP6) in stabilizing the morphology of dentine collagen network and resin-dentine bonding. METHODS: Dentine beams were fully demineralized with 10% phosphoric acid (PA) or 1% IP6 (pH 1.2). …

OBJECTIVE: This study examined the effect of phytic acid (IP6) in stabilizing the morphology of dentine collagen networ …

199

Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate.

Sahay S, Tiwari P, Gupta KP. Sahay S, et al. Toxicol Rep. 2015 Apr 2;2:590-599. doi: 10.1016/j.toxrep.2015.03.010. eCollection 2015. Toxicol Rep. 2015. PMID: 28962394 Free PMC article.

We evaluated the effects of N-ethyl-N-nitrosourea (ENU) given on the 17th day of gestation and antitumour agent inositol hexaphosphate (IP6) to the mothers at the early stage of lung tumourigenesis in F1 mice. ...IP6 administration also inhibited the a …

We evaluated the effects of N-ethyl-N-nitrosourea (ENU) given on the 17th day of gestation and antitumour agent inositol hexaphosp …

200

A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine.

Wilson MS, Bulley SJ, Pisani F, Irvine RF, Saiardi A. Wilson MS, et al. Open Biol. 2015 Mar;5(3):150014. doi: 10.1098/rsob.150014. Open Biol. 2015. PMID: 25808508 Free PMC article.

Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized. A key obstacle in inositol phosphate research in mam …

Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions …

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