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Ca v 1.2 L-type Ca2+ channel protects mast cells against activation-induced cell death by preventing mitochondrial integrity disruption.
Suzuki Y, Yoshimaru T, Inoue T, Ra C. Suzuki Y, et al. Among authors: inoue t. Mol Immunol. 2009 Jul;46(11-12):2370-80. doi: 10.1016/j.molimm.2009.03.017. Epub 2009 May 17. Mol Immunol. 2009. PMID: 19447492
Recently, store-independent Ca(2+) channels which are pharmacologically and/or immunologically similar to L-type Ca(2+) channels (LTCCs) have been shown to exist in various hematopoietic cells, including T cells, B cells and neutrophils. ...
Recently, store-independent Ca(2+) channels which are pharmacologically and/or immunologically similar to L-type Ca(2+) channels (LTCCs) hav …
Calcium signaling in mast cells: focusing on L-type calcium channels.
Suzuki Y, Inoue T, Ra C. Suzuki Y, et al. Among authors: inoue t. Adv Exp Med Biol. 2012;740:955-77. doi: 10.1007/978-94-007-2888-2_44. Adv Exp Med Biol. 2012. PMID: 22453979 Review.
Autoimmunity-inducing metals (Hg, Au and Ag) modulate mast cell signaling, function and survival.
Suzuki Y, Inoue T, Ra C. Suzuki Y, et al. Among authors: inoue t. Curr Pharm Des. 2011 Nov;17(34):3805-14. doi: 10.2174/138161211798357917. Curr Pharm Des. 2011. PMID: 22103852 Review.
The disorders are characterized by autoantibody production, increases in serum IgG and IgE, polyclonal activation of B and T lymphocytes and renal immune complex deposition and glomerulonephritis. ...
The disorders are characterized by autoantibody production, increases in serum IgG and IgE, polyclonal activation of B and T lymphocy …
Gold activates mast cells via calcium influx through multiple H2O2-sensitive pathways including L-type calcium channels.
Hayama K, Suzuki Y, Inoue T, Ochiai T, Terui T, Ra C. Hayama K, et al. Among authors: inoue t. Free Radic Biol Med. 2011 May 15;50(10):1417-28. doi: 10.1016/j.freeradbiomed.2011.02.025. Epub 2011 Mar 1. Free Radic Biol Med. 2011. PMID: 21376117
Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death.
Nakata K, Suzuki Y, Inoue T, Ra C, Yakura H, Mizuno K. Nakata K, et al. Among authors: inoue t. Mol Immunol. 2011 Jan;48(4):472-80. doi: 10.1016/j.molimm.2010.10.001. Epub 2010 Nov 1. Mol Immunol. 2011. PMID: 21044800
Epigallocatechin-3-gallate inhibits mast cell degranulation, leukotriene C4 secretion, and calcium influx via mitochondrial calcium dysfunction.
Inoue T, Suzuki Y, Ra C. Inoue T, et al. Free Radic Biol Med. 2010 Aug 15;49(4):632-40. doi: 10.1016/j.freeradbiomed.2010.05.015. Epub 2010 May 25. Free Radic Biol Med. 2010. PMID: 20510351
L-type Ca2+ channels: a new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells.
Suzuki Y, Inoue T, Ra C. Suzuki Y, et al. Among authors: inoue t. Mol Immunol. 2010 Jan;47(4):640-8. doi: 10.1016/j.molimm.2009.10.013. Epub 2009 Nov 18. Mol Immunol. 2010. PMID: 19926136 Review.
Endothelial nitric oxide synthase is essential for nitric oxide generation, L-type Ca2+ channel activation and survival in RBL-2H3 mast cells.
Suzuki Y, Inoue T, Ra C. Suzuki Y, et al. Among authors: inoue t. Biochim Biophys Acta. 2010 Mar;1803(3):372-85. doi: 10.1016/j.bbamcr.2009.11.003. Epub 2009 Nov 24. Biochim Biophys Acta. 2010. PMID: 19925832
SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways.
Inoue T, Suzuki Y, Mizuno K, Nakata K, Yoshimaru T, Ra C. Inoue T, et al. Mol Immunol. 2009 Dec;47(2-3):222-32. doi: 10.1016/j.molimm.2009.09.033. Epub 2009 Oct 28. Mol Immunol. 2009. PMID: 19875169
Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway.
Inoue T, Suzuki Y, Yoshimaru T, Ra C. Inoue T, et al. J Leukoc Biol. 2009 Dec;86(6):1365-75. doi: 10.1189/jlb.0609387. Epub 2009 Aug 25. J Leukoc Biol. 2009. PMID: 19706839
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