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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1998 2
1999 1
2000 7
2001 2
2002 1
2003 3
2004 5
2005 4
2006 3
2007 4
2008 4
2009 4
2010 2
2011 2
2012 2
2013 1
2014 2
2015 2
2017 1
2018 4
2019 2
2020 2
2021 3
2022 2
2023 1
2024 1

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58 results

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Page 1
Autophagy in the physiological endometrium and cancer.
Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D. Devis-Jauregui L, et al. Autophagy. 2021 May;17(5):1077-1095. doi: 10.1080/15548627.2020.1752548. Epub 2020 May 13. Autophagy. 2021. PMID: 32401642 Free PMC article. Review.
Autophagy is a highly conserved catabolic process and a major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. ...Current research efforts aiming to therapeutically exploit autophagy and the methodological approaches used are discusse …
Autophagy is a highly conserved catabolic process and a major cellular pathway for the degradation of long-lived proteins and cytopla …
Insulin activates caspase-3 by a phosphatidylinositol 3'-kinase-dependent pathway.
Godbout JP, Cengel KA, Cheng SL, Minshall C, Kelley KW, Freund GG. Godbout JP, et al. Cell Signal. 1999 Jan;11(1):15-23. doi: 10.1016/s0898-6568(98)00024-2. Cell Signal. 1999. PMID: 10206340
Here we report that insulin activates caspase-3 by a pathway requiring phosphatidylinositol 3'-kinase (PI3-kinase). ...Taken together, these findings indicate that insulin activates caspase-3 by a …
Here we report that insulin activates caspase-3 by a pathway requiring phosphatidylinositol 3
Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism.
Tan J, Digicaylioglu M, Wang SXJ, Dresselhuis J, Dedhar S, Mills J. Tan J, et al. Heliyon. 2019 Aug 16;5(8):e02294. doi: 10.1016/j.heliyon.2019.e02294. eCollection 2019 Aug. Heliyon. 2019. PMID: 31463398 Free PMC article.
Insulin promotes neuronal survival by activating a phosphatidylinositol 3-kinase (PI 3-kinase)/AKT-dependent signaling pathway and reducing caspase activation. ...Insulin and IGF-1 decreased caspase
Insulin promotes neuronal survival by activating a phosphatidylinositol 3-kinase (PI 3-kinase
Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.
Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW. Barber AJ, et al. J Biol Chem. 2001 Aug 31;276(35):32814-21. doi: 10.1074/jbc.M104738200. Epub 2001 Jul 6. J Biol Chem. 2001. PMID: 11443130 Free article.
Insulin induced serine phosphorylation of Akt, through the phosphatidylinositol (PI) 3-kinase pathway. ...These results suggest that insulin is a survival factor for retinal neurons by activating the PI 3-kinase/Akt
Insulin induced serine phosphorylation of Akt, through the phosphatidylinositol (PI) 3-kinase pathway. ..
Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway.
Chen RH, Su YH, Chuang RL, Chang TY. Chen RH, et al. Oncogene. 1998 Oct 15;17(15):1959-68. doi: 10.1038/sj.onc.1202111. Oncogene. 1998. PMID: 9788439
The Ras/mitogen-activated protein kinase (MAP kinase) and the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathways are both activated upon insulin stimulation and can protect against apoptosis under certain circum …
The Ras/mitogen-activated protein kinase (MAP kinase) and the phosphatidylinositol 3-kinase (PI 3-kina
Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway.
Subramaniam S, Shahani N, Strelau J, Laliberté C, Brandt R, Kaplan D, Unsicker K. Subramaniam S, et al. J Neurosci. 2005 Mar 16;25(11):2838-52. doi: 10.1523/JNEUROSCI.5060-04.2005. J Neurosci. 2005. PMID: 15772344 Free PMC article.
Phosphatidylinositol 3-kinase (PI3K) or PKA inhibitors, but not a specific Akt inhibitor, abrogated PKA signaling. ...Activation of caspase-3 promoted DNA damage. Its inhibition by IGF-1 was both PI3K and Akt dependent but PKA inde
Phosphatidylinositol 3-kinase (PI3K) or PKA inhibitors, but not a specific Akt inhibitor, abrogated PKA signaling. ...
Insulin inhibits caspase-3 activity in human renal tubular epithelial cells via the PI3-kinase/Akt pathway.
Meier M, Nitschke M, Hocke C, Kramer J, Jabs W, Steinhoff J, Schutt M. Meier M, et al. Cell Physiol Biochem. 2008;21(4):279-86. doi: 10.1159/000129386. Epub 2008 Apr 23. Cell Physiol Biochem. 2008. PMID: 18441516 Free article.
Apoptosis was induced by camptothecin incubation. Insulin receptor kinase (IR-kinase) activity, phosphorylation of insulin receptor substrate-1 (IRS-1), IRS-1-associated PI3-kinase (p85), Ser(273)-phosphorylation of Akt and caspase-3 activity
Apoptosis was induced by camptothecin incubation. Insulin receptor kinase (IR-kinase) activity, phosphorylation of insulin
Protective effects of curcumin on desipramine-induced islet β-cell damage via AKAP150/PKA/PP2B complex.
Hu M, Cai JY, He Y, Chen K, Hao F, Kang JS, Pan Y, Tie L, Li XJ. Hu M, et al. Acta Pharmacol Sin. 2024 Feb;45(2):327-338. doi: 10.1038/s41401-023-01176-6. Epub 2023 Oct 16. Acta Pharmacol Sin. 2024. PMID: 37845344
We demonstrated that desipramine treatment promoted the cleavage and activation of Caspase 3 in RIN-m5F cells. Curcumin treatment inhibited desipramine-induced apoptosis, increased mitochondrial membrane potential and Bcl-2/Bax ratio. ...These results suggest …
We demonstrated that desipramine treatment promoted the cleavage and activation of Caspase 3 in RIN-m5F cells. Curcumin …
Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells.
Kaifu K, Kiyomoto H, Hitomi H, Matsubara K, Hara T, Moriwaki K, Ihara G, Fujita Y, Sugasawa N, Nagata D, Nishiyama A, Kohno M. Kaifu K, et al. Nephrol Dial Transplant. 2009 Mar;24(3):809-15. doi: 10.1093/ndt/gfn598. Epub 2008 Oct 30. Nephrol Dial Transplant. 2009. PMID: 18974235
To clarify this hypothesis, we examined the effects of insulin on the phosphatidylinositol 3-kinase/Akt signaling pathway and apoptosis in rat peritoneal mesothelial cells. ...Treatment with the phosphatidylinositol 3-kinase
To clarify this hypothesis, we examined the effects of insulin on the phosphatidylinositol 3-kinase/Akt signalin …
Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells.
Kang S, Song J, Kang H, Kim S, Lee Y, Park D. Kang S, et al. Eur J Endocrinol. 2003 Jan;148(1):147-55. doi: 10.1530/eje.0.1480147. Eur J Endocrinol. 2003. PMID: 12534368
Western blot analysis was performed to identify signaling molecules activated in response to insulin. RESULTS: Serum starvation resulted in a marked accumulation of ROS, activation of caspase-3, and subsequent apoptotic cell death which were, in …
Western blot analysis was performed to identify signaling molecules activated in response to insulin. RESULTS: Serum starvatio …
58 results