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Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.
Buick JK, Moffat I, Williams A, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL. Buick JK, et al. Environ Mol Mutagen. 2015 Jul;56(6):520-34. doi: 10.1002/em.21940. Epub 2015 Mar 2. Environ Mol Mutagen. 2015. PMID: 25733247 Free PMC article.
In a companion article, a genomic biomarker was developed in human TK6 cells to classify chemicals as genotoxic or nongenotoxic. Because TK6 cells are not metabolically competent, we set out to broaden the utility of …
In a companion article, a genomic biomarker was developed in human TK6 cells to classify chemicals as …
A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells.
Williams A, Buick JK, Moffat I, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL. Williams A, et al. Data Brief. 2015 Aug 24;5:77-83. doi: 10.1016/j.dib.2015.08.013. eCollection 2015 Dec. Data Brief. 2015. PMID: 26425668 Free PMC article.
Microarray-based transcriptomic analyses were then used to develop a classifier for genotoxicity using the nearest shrunken centroids method. A panel of 65 genes was identified that could accurately classify toxicants as genotoxic or non-genotoxic …
Microarray-based transcriptomic analyses were then used to develop a classifier for genotoxicity using the nearest shrunken ce …