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Integrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expression.
Hu X, Han C, Jin J, Qin K, Zhang H, Li T, Li N, Cao X. Hu X, et al. Sci Rep. 2016 May 18;6:26252. doi: 10.1038/srep26252. Sci Rep. 2016. PMID: 27188220 Free PMC article.
Importantly, Src inhibitor dasatinib aggravated DSS-induced colitis by decreasing IL-10 while increasing TNF-alpha in vivo. Therefore, CD11b promotes IL-10 production by activating Src-Akt signal pathway. An axis of …
Importantly, Src inhibitor dasatinib aggravated DSS-induced colitis by decreasing IL-10 while increasing TNF-alpha in v …