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Interaction of Shiga toxin 2 with complement regulators of the factor H protein family.
Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R. Poolpol K, et al. Mol Immunol. 2014 Mar;58(1):77-84. doi: 10.1016/j.molimm.2013.11.009. Epub 2013 Dec 5. Mol Immunol. 2014. PMID: 24317278
Shiga toxin 2 (Stx2) is believed to be a major virulence factor of enterohemorrhagic Escherichia coli (EHEC) contributing to hemolytic uremic syndrome (HUS). ...We now show that complement factor H-related protein 1 (FHR-1)
Shiga toxin 2 (Stx2) is believed to be a major virulence factor of enterohemorrhagic Escherichia coli (EHEC) con
Role of complement in enterohemorrhagic Escherichia coli-Induced hemolytic uremic syndrome.
Orth-Höller D, Würzner R. Orth-Höller D, et al. Semin Thromb Hemost. 2014 Jun;40(4):503-7. doi: 10.1055/s-0034-1375295. Epub 2014 May 5. Semin Thromb Hemost. 2014. PMID: 24799304 Review.
Besides its cytotoxic activity, Stx has been shown to interact with the complement system. Complement breakdown products have been found in serum of HUS patients suggesting complement activation and in vitro studies have demonstrated that Stx2 d …
Besides its cytotoxic activity, Stx has been shown to interact with the complement system. Complement breakdown …