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Interaction of Shiga toxin 2 with complement regulators of the factor H protein family.
Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R. Poolpol K, et al. Mol Immunol. 2014 Mar;58(1):77-84. doi: 10.1016/j.molimm.2013.11.009. Epub 2013 Dec 5. Mol Immunol. 2014. PMID: 24317278
Shiga toxin 2 (Stx2) is believed to be a major virulence factor of enterohemorrhagic Escherichia coli (EHEC) contributing to hemolytic uremic syndrome (HUS). ...We now show that complement factor H-related protein 1 (FHR-1) and
Shiga toxin 2 (Stx2) is believed to be a major virulence factor of enterohemorrhagic Escherichia coli (EHEC) contributi
Role of complement in enterohemorrhagic Escherichia coli-Induced hemolytic uremic syndrome.
Orth-Höller D, Würzner R. Orth-Höller D, et al. Semin Thromb Hemost. 2014 Jun;40(4):503-7. doi: 10.1055/s-0034-1375295. Epub 2014 May 5. Semin Thromb Hemost. 2014. PMID: 24799304 Review.
Binding of Stx2 has also been shown for other members of the FH family, namely FH-like protein 1 and FH-related protein 1. Both proteins also compete with FH for Stx binding, so that in the presence of FHR-1 less FH is bound to Stx and therefore more i …
Binding of Stx2 has also been shown for other members of the FH family, namely FH-like protein 1 and FH-related protein