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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1840 1
1864 1
1872 1
1897 1
1899 1
1900 1
1901 2
1902 1
1905 1
1906 2
1908 1
1909 2
1910 4
1911 5
1913 4
1915 1
1917 1
1918 3
1919 2
1920 4
1921 2
1922 2
1923 3
1924 3
1925 2
1926 6
1927 2
1928 3
1929 4
1930 6
1931 3
1932 5
1933 4
1934 5
1935 6
1936 5
1937 11
1938 6
1939 4
1940 7
1941 5
1942 3
1943 5
1944 2
1945 5
1946 16
1947 27
1948 32
1949 28
1950 37
1951 51
1952 61
1953 78
1954 56
1955 72
1956 71
1957 79
1958 95
1959 102
1960 102
1961 120
1962 161
1963 180
1964 174
1965 239
1966 278
1967 318
1968 316
1969 367
1970 383
1971 375
1972 445
1973 482
1974 509
1975 1584
1976 1726
1977 1588
1978 1613
1979 1764
1980 2005
1981 2185
1982 2551
1983 2950
1984 3346
1985 3566
1986 3760
1987 3902
1988 4061
1989 4507
1990 4660
1991 4835
1992 4982
1993 5215
1994 5468
1995 5460
1996 5888
1997 5854
1998 6136
1999 6414
2000 7261
2001 7764
2002 8015
2003 8269
2004 8910
2005 9829
2006 10250
2007 10821
2008 11177
2009 11696
2010 12613
2011 13290
2012 14146
2013 14706
2014 15290
2015 15753
2016 16315
2017 16594
2018 16975
2019 17713
2020 14473
2021 23
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337,022 results
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Page 1
Cytotoxic Curli Intermediates Form during Salmonella Biofilm Development.
Nicastro LK, Tursi SA, Le LS, Miller AL, Efimov A, Buttaro B, Tam V, Tükel Ç. Nicastro LK, et al. J Bacteriol. 2019 Aug 22;201(18):e00095-19. doi: 10.1128/JB.00095-19. Print 2019 Sep 15. J Bacteriol. 2019. PMID: 31182496 Free PMC article.
Similar to the intermediate oligomers of amyloid β, intermediate curli aggregates were more cytotoxic than the mature curli fibrils when incubated with bone marrow-derived macrophages. ...Here we detected oligomeric intermediates of curli for the first time. …
Similar to the intermediate oligomers of amyloid β, intermediate curli aggregates were more cytotoxic than the mature curli fi …
Didehydroisobenzofuran: A New Reactive Intermediate for Construction of Isoacenofuran.
Matsuoka S, Jung S, Miyakawa K, Chuda Y, Sugimoto R, Hamura T. Matsuoka S, et al. Chemistry. 2018 Dec 17;24(71):18886-18889. doi: 10.1002/chem.201804655. Epub 2018 Nov 14. Chemistry. 2018. PMID: 30328164
The reactive intermediate, thus generated, was trapped by appropriate arynophile to give the [2+2], [2+3], and [2+4] cycloadducts, respectively. ...
The reactive intermediate, thus generated, was trapped by appropriate arynophile to give the [2+2], [2+3], and [2+4] cycloadducts, re …
Single-Molecule Observation of the Intermediates in a Catalytic Cycle.
Ramsay WJ, Bell NAW, Qing Y, Bayley H. Ramsay WJ, et al. J Am Chem Soc. 2018 Dec 19;140(50):17538-17546. doi: 10.1021/jacs.8b09282. Epub 2018 Dec 10. J Am Chem Soc. 2018. PMID: 30472844
The development of catalysts benefits from knowledge of the intermediate steps that accelerate the transformations of substrates into products. ...Measurements of the lifetimes of the intermediates allowed a full kinetic analysis of the metal-catalyzed reaction cycl …
The development of catalysts benefits from knowledge of the intermediate steps that accelerate the transformations of substrates into …
Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin.
Baidilov D, Rycek L, Trant JF, Froese J, Murphy B, Hudlicky T. Baidilov D, et al. Angew Chem Int Ed Engl. 2018 Aug 20;57(34):10994-10998. doi: 10.1002/anie.201804602. Epub 2018 May 30. Angew Chem Int Ed Engl. 2018. PMID: 29750851
Advanced intermediates for the syntheses of tetrodotoxin reported by the groups of Fukuyama, Alonso, and Sato were prepared. ...The resulting diene diols were transformed into Fukuyama's intermediate in six steps, into Alonso's intermediate in nine steps, and …
Advanced intermediates for the syntheses of tetrodotoxin reported by the groups of Fukuyama, Alonso, and Sato were prepared. ...The r …
Atomic-Scale Visualization of the Stepwise Metal-Mediated Dehalogenative Cycloaddition Reaction Pathways: Competition between Radicals and Organometallic Intermediates.
Zhang C, Kazuma E, Kim Y. Zhang C, et al. Angew Chem Int Ed Engl. 2019 Dec 2;58(49):17736-17744. doi: 10.1002/anie.201909111. Epub 2019 Oct 23. Angew Chem Int Ed Engl. 2019. PMID: 31591789 Review.
Now, the evolutions of competing surface-stabilized radicals and organometallic intermediates in real space were visualized toward the formation of dominant conjugated four-membered ring connections. ...The results provide fundamental insights into the intermediate …
Now, the evolutions of competing surface-stabilized radicals and organometallic intermediates in real space were visualized toward th …
Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in Vitamin K Biosynthesis.
Qin M, Song H, Dai X, Chan CK, Chan W, Guo Z. Qin M, et al. Chembiochem. 2018 Jul 16;19(14):1514-1522. doi: 10.1002/cbic.201800143. Epub 2018 Jun 19. Chembiochem. 2018. PMID: 29726079
By real-time monitoring of the cofactor chemical state with circular dichroism spectroscopy, we found that a new post-decarboxylation intermediate was formed from a multistep process that was rate limited by binding of the α-ketoglutarate substrate before it quickly relaxe …
By real-time monitoring of the cofactor chemical state with circular dichroism spectroscopy, we found that a new post-decarboxylation int …
Clinical implications of vancomycin heteroresistant and intermediately susceptible Staphylococcus aureus.
Gomes DM, Ward KE, LaPlante KL. Gomes DM, et al. Pharmacotherapy. 2015 Apr;35(4):424-32. doi: 10.1002/phar.1577. Pharmacotherapy. 2015. PMID: 25884530 Review.
Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infec …
Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections …
Charge Dispersion and Its Effects on the Reactivity of Thiamin-Derived Breslow Intermediates.
Bielecki M, Howe GW, Kluger R. Bielecki M, et al. Biochemistry. 2018 Jul 3;57(26):3867-3872. doi: 10.1021/acs.biochem.8b00463. Epub 2018 Jun 15. Biochemistry. 2018. PMID: 29856601
Our study reveals that nonenzymic decarboxylation of the related thiamin adducts proceeds to the alternative charge-dispersed enol form of the Breslow intermediate. ...Applying Guthrie's "no-barrier" addition to Marcus theory also leads to the conclusion that maintaining t …
Our study reveals that nonenzymic decarboxylation of the related thiamin adducts proceeds to the alternative charge-dispersed enol form of t …
Time-resolved FTIR study of light-driven sodium pump rhodopsins.
Chen HF , Inoue K , Ono H , Abe-Yoshizumi R , Wada A , Kandori H . Chen HF , et al. Phys Chem Chem Phys. 2018 Jul 4;20(26):17694-17704. doi: 10.1039/c8cp02599a. Phys Chem Chem Phys. 2018. PMID: 29938283
Strong hydrogen-out-of-plane (HOOP) vibrations, which appeared in the K intermediate, are common among other rhodopsins. It is, however, unique for NaR that such HOOP bands are persistent in late intermediates, such as L and O intermediates. This observation …
Strong hydrogen-out-of-plane (HOOP) vibrations, which appeared in the K intermediate, are common among other rhodopsins. It is, howev …
Retinal Configuration of ppR Intermediates Revealed by Photoirradiation Solid-State NMR and DFT.
Makino Y, Kawamura I, Okitsu T, Wada A, Kamo N, Sudo Y, Ueda K, Naito A. Makino Y, et al. Biophys J. 2018 Jul 3;115(1):72-83. doi: 10.1016/j.bpj.2018.05.030. Biophys J. 2018. PMID: 29972813 Free PMC article.
The signals caused by the N'-intermediate appeared at 115.4 and 23.9 ppm and were assigned to the 13-cis configuration, and they were in an equilibrium state with the O-intermediate during thermal decay of the M-intermediates at -60°C. Thus, photoirradiation …
The signals caused by the N'-intermediate appeared at 115.4 and 23.9 ppm and were assigned to the 13-cis configuration, and they were …
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