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The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells.
Park JM, Kohn MJ, Bruinsma MW, Vech C, Intine RV, Fuhrmann S, Grinberg A, Mukherjee I, Love PE, Ko MS, DePamphilis ML, Maraia RJ. Park JM, et al. Mol Cell Biol. 2006 Feb;26(4):1445-51. doi: 10.1128/MCB.26.4.1445-1451.2006. Mol Cell Biol. 2006. PMID: 16449655 Free PMC article.
Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.
Huang Y, Intine RV, Mozlin A, Hasson S, Maraia RJ. Huang Y, et al. Mol Cell Biol. 2005 Jan;25(2):621-36. doi: 10.1128/MCB.25.2.621-636.2005. Mol Cell Biol. 2005. PMID: 15632064 Free PMC article.
Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.
Intine RV, Dundr M, Vassilev A, Schwartz E, Zhao Y, Zhao Y, Depamphilis ML, Maraia RJ. Intine RV, et al. Mol Cell Biol. 2004 Dec;24(24):10894-904. doi: 10.1128/MCB.24.24.10894-10904.2004. Mol Cell Biol. 2004. PMID: 15572691 Free PMC article.
La protein and its associated small nuclear and nucleolar precursor RNAs.
Maraia RJ, Intine RV. Maraia RJ, et al. Gene Expr. 2002;10(1-2):41-57. Gene Expr. 2002. PMID: 11868987 Free PMC article. Review.
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