Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice.
Zhou Y, Tu C, Coutton C, Tang J, Tian S, Tang S, Martinez G, Zhou D, Tebbakh C, Wang J, Zouari R, Zhou X, Ben Mustapha SF, Wang X, Wu B, Geng X, Liu S, Jin L, Shi H, Tan YQ, Ray PF, Wang L, Yang X, Zhang F, Liu C.
Zhou Y, et al.
Sci China Life Sci. 2025 Mar;68(3):777-792. doi: 10.1007/s11427-024-2757-7. Epub 2024 Dec 18.
Sci China Life Sci. 2025.
PMID: 39704931
Subsequently, we generated a Mycbpap knockout (Mycbpap(-/-)) mouse model, which also exhibited male infertility with reduced sperm motility and abnormal morphologies in sperm heads and flagella. ...Furthermore, MYCBPAP-associated male inferti …
Subsequently, we generated a Mycbpap knockout (Mycbpap(-/-)) mouse model, which also exhibited male infertility with reduced …