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2012 1
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Page 1
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Gerlinger M, Rowan AJ, Horswell S, Math M, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C. Gerlinger M, et al. N Engl J Med. 2012 Mar 8;366(10):883-892. doi: 10.1056/NEJMoa1113205. N Engl J Med. 2012. PMID: 22397650 Free PMC article.
We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. ...Allelic composition and ploidy profiling analysis revealed exten …
We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional …
Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer.
Ma L, Heinrich S, Wang L, Keggenhoff FL, Khatib S, Forgues M, Kelly M, Hewitt SM, Saif A, Hernandez JM, Mabry D, Kloeckner R, Greten TF, Chaisaingmongkol J, Ruchirawat M, Marquardt JU, Wang XW. Ma L, et al. Nat Commun. 2022 Dec 7;13(1):7533. doi: 10.1038/s41467-022-35291-5. Nat Commun. 2022. PMID: 36476645 Free PMC article.
Intratumor heterogeneity may result from the evolution of tumor cells and their continuous interactions with the tumor microenvironment which collectively drives tumorigenesis. ...Here we perform multiregional single-cell RNA sequencing (scRNA-s …
Intratumor heterogeneity may result from the evolution of tumor cells and their continuous interactions with the tumor …
Multiregion sequencing and subclonal analysis reveal intratumoral heterogeneity in esophageal squamous cell carcinoma.
Gao D, Zhang Z, Yang Q, Li B. Gao D, et al. J Cancer Res Ther. 2021 Jul;17(3):756-763. doi: 10.4103/jcrt.jcrt_270_21. J Cancer Res Ther. 2021. PMID: 34269310 Free article.
MATERIALS AND METHODS: Multiregion whole-exome sequencing was performed on 24 surgically acquired tumor samples from five untreated ESCC patients collected in 2019 to determine the heterogeneity of mutational landscape within tumors. ...RESULTS: An average of …
MATERIALS AND METHODS: Multiregion whole-exome sequencing was performed on 24 surgically acquired tumor samples from five untr …
Multiregion sequencing reveals the intratumor heterogeneity of driver mutations in TP53-driven non-small cell lung cancer.
Zhang LL, Kan M, Zhang MM, Yu SS, Xie HJ, Gu ZH, Wang HN, Zhao SX, Zhou GB, Song HD, Zheng CX. Zhang LL, et al. Int J Cancer. 2017 Jan 1;140(1):103-108. doi: 10.1002/ijc.30437. Epub 2016 Oct 3. Int J Cancer. 2017. PMID: 27646734
A total of 12-paired normal-tumor tissues were subjected to whole-genome/whole-exome sequencing. From these, 367 non-silent mutations were selected as driver mutations and deeply sequenced in 61 intratumoral microdissections. We identified a universal prevale …
A total of 12-paired normal-tumor tissues were subjected to whole-genome/whole-exome sequencing. From these, 367 non-silent mutations …
Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing.
Lu YW, Zhang HF, Liang R, Xie ZR, Luo HY, Zeng YJ, Xu Y, Wang LM, Kong XY, Wang KH. Lu YW, et al. PLoS One. 2016 Mar 29;11(3):e0152673. doi: 10.1371/journal.pone.0152673. eCollection 2016. PLoS One. 2016. PMID: 27023146 Free PMC article.
Intratumor heterogeneity (ITH) leads to an underestimation of the mutational landscape portrayed by a single needle biopsy and consequently affects treatment precision. ...KMT2C aberrations and the NCOR1 mutation were the only ubiquitous events. Subsequent phylogene …
Intratumor heterogeneity (ITH) leads to an underestimation of the mutational landscape portrayed by a single needle biopsy and …
Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.
Dong LQ, Shi Y, Ma LJ, Yang LX, Wang XY, Zhang S, Wang ZC, Duan M, Zhang Z, Liu LZ, Zheng BH, Ding ZB, Ke AW, Gao DM, Yuan K, Zhou J, Fan J, Xi R, Gao Q. Dong LQ, et al. J Hepatol. 2018 Jul;69(1):89-98. doi: 10.1016/j.jhep.2018.02.029. Epub 2018 Mar 16. J Hepatol. 2018. PMID: 29551704 Free article.
LAY SUMMARY: We applied multiregional whole-exome sequencing to investigate the evolution of intrahepatic cholangiocarcinoma (ICC). The results revealed that many factors, such as parallel evolution and chromosome instability, may participate an …
LAY SUMMARY: We applied multiregional whole-exome sequencing to investigate the evolution of intrahepatic cholangiocarc …
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.
Zhang M, Luo JL, Sun Q, Harber J, Dawson AG, Nakas A, Busacca S, Sharkey AJ, Waller D, Sheaff MT, Richards C, Wells-Jordan P, Gaba A, Poile C, Baitei EY, Bzura A, Dzialo J, Jama M, Le Quesne J, Bajaj A, Martinson L, Shaw JA, Pritchard C, Kamata T, Kuse N, Brannan L, De Philip Zhang P, Yang H, Griffiths G, Wilson G, Swanton C, Dudbridge F, Hollox EJ, Fennell DA. Zhang M, et al. Nat Commun. 2021 Mar 19;12(1):1751. doi: 10.1038/s41467-021-21798-w. Nat Commun. 2021. PMID: 33741915 Free PMC article.
To elucidate this path, we conducted multi-regional exome sequencing of 90 tumour samples from 22 MPMs acquired at surgery. Here we show that exomic intratumour heterogeneity varies widely across the cohort. Phylogenetic tree topology ranges from linear to hi …
To elucidate this path, we conducted multi-regional exome sequencing of 90 tumour samples from 22 MPMs acquired at surgery. Here we s …
Whole exome sequencing of multi-regions reveals tumor heterogeneity in Opisthorchis viverrini-associated cholangiocarcinoma.
Sitthirak S, Wangwiwatsin A, Jusakul A, Namwat N, Klanrit P, Dokduang H, Sa-Ngiamwibool P, Titapun A, Jareanrat A, Thanasukarn V, Khuntikeo N, Teh BT, Boulter L, Murakami Y, Loilome W. Sitthirak S, et al. Sci Rep. 2025 Mar 29;15(1):10886. doi: 10.1038/s41598-025-95142-3. Sci Rep. 2025. PMID: 40157958 Free PMC article.
The study examines Opisthorchis viverrini (OV)-related cholangiocarcinoma (CCA), a serious malignancy common in Southeast Asia. Through multi-regional whole-exome sequencing of 52 tumor samples and 13 adjacent tissues from 13 patients, significant intratumoral he …
The study examines Opisthorchis viverrini (OV)-related cholangiocarcinoma (CCA), a serious malignancy common in Southeast Asia. Through mult …
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