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Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.
Nat Biotechnol. 1998 Jan;16(1):69-74. doi: 10.1038/nbt0198-69.
Nat Biotechnol. 1998.
PMID: 9447597
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.
Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR.
Lomovskaya N, et al. Among authors: inventi solari a.
J Bacteriol. 1999 Jan;181(1):305-18. doi: 10.1128/JB.181.1.305-318.1999.
J Bacteriol. 1999.
PMID: 9864344
Free PMC article.
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Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius.
Colombo AL, Solinas MM, Perini G, Biamonti G, Zanella G, Caruso M, Torti F, Filippini S, Inventi-Solari A, Garofano L.
Colombo AL, et al. Among authors: inventi solari a.
J Bacteriol. 1992 Mar;174(5):1641-6. doi: 10.1128/jb.174.5.1641-1646.1992.
J Bacteriol. 1992.
PMID: 1537806
Free PMC article.
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