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Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Chonan T, Wakasugi D, Yamamoto D, Yashiro M, Oi T, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A. Chonan T, et al. Among authors: io f. Bioorg Med Chem. 2011 Mar 1;19(5):1580-93. doi: 10.1016/j.bmc.2011.01.041. Epub 2011 Jan 27. Bioorg Med Chem. 2011. PMID: 21324704
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, Yamamoto K. Kakinuma H, et al. Among authors: io f. J Med Chem. 2010 Apr 22;53(8):3247-61. doi: 10.1021/jm901893x. J Med Chem. 2010. PMID: 20302302
Identification of 2-[2-(4-tert-Butylphenyl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide as an Orally Active MGAT2 Inhibitor.
Busujima T, Tanaka H, Iwakiri K, Shirasaki Y, Munetomo E, Saito M, Masuko A, Kitano K, Io F, Kato K, Kamigaso S, Nozoe A, Sato N. Busujima T, et al. Among authors: io f. Chem Pharm Bull (Tokyo). 2016;64(3):228-38. doi: 10.1248/cpb.c15-00803. Chem Pharm Bull (Tokyo). 2016. PMID: 26936050 Free article.
13 results