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The NPC1 protein: structure implies function.
Scott C, Ioannou YA. Scott C, et al. Among authors: ioannou ya. Biochim Biophys Acta. 2004 Oct 11;1685(1-3):8-13. doi: 10.1016/j.bbalip.2004.08.006. Biochim Biophys Acta. 2004. PMID: 15465421 Review.
Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes.
Higgins ME, Ioannou YA. Higgins ME, et al. Among authors: ioannou ya. J Lipid Res. 2001 Dec;42(12):1939-46. J Lipid Res. 2001. PMID: 11734566
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.
Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H. Knöpfel M, et al. Among authors: ioannou ya. Biochim Biophys Acta. 2007 Sep;1771(9):1140-7. doi: 10.1016/j.bbalip.2007.05.011. Epub 2007 Jun 23. Biochim Biophys Acta. 2007. PMID: 17689140
Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.
Labonté ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY. Labonté ED, et al. Among authors: ioannou ya. Biochim Biophys Acta. 2007 Sep;1771(9):1132-9. doi: 10.1016/j.bbalip.2007.03.002. Epub 2007 Mar 16. Biochim Biophys Acta. 2007. PMID: 17442616 Free PMC article.
Transmembrane molecular pump activity of Niemann-Pick C1 protein.
Davies JP, Chen FW, Ioannou YA. Davies JP, et al. Among authors: ioannou ya. Science. 2000 Dec 22;290(5500):2295-8. doi: 10.1126/science.290.5500.2295. Science. 2000. PMID: 11125140
Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein.
Davies JP, Ioannou YA. Davies JP, et al. Among authors: ioannou ya. J Biol Chem. 2000 Aug 11;275(32):24367-74. doi: 10.1074/jbc.M002184200. J Biol Chem. 2000. PMID: 10821832
Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.
Davies JP, Levy B, Ioannou YA. Davies JP, et al. Among authors: ioannou ya. Genomics. 2000 Apr 15;65(2):137-45. doi: 10.1006/geno.2000.6151. Genomics. 2000. PMID: 10783261
Ribosomal proteins in cell proliferation and apoptosis.
Chen FW, Ioannou YA. Chen FW, et al. Among authors: ioannou ya. Int Rev Immunol. 1999;18(5-6):429-48. doi: 10.3109/08830189909088492. Int Rev Immunol. 1999. PMID: 10672495 Review.
Multidrug permeases and subcellular cholesterol transport.
Ioannou YA. Ioannou YA. Nat Rev Mol Cell Biol. 2001 Sep;2(9):657-68. doi: 10.1038/35089558. Nat Rev Mol Cell Biol. 2001. PMID: 11533723 Review.
The structure and function of the Niemann-Pick C1 protein.
Ioannou YA. Ioannou YA. Mol Genet Metab. 2000 Sep-Oct;71(1-2):175-81. doi: 10.1006/mgme.2000.3061. Mol Genet Metab. 2000. PMID: 11001808 Review.
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