Abstract
PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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COS Cells
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Calcium-Calmodulin-Dependent Protein Kinases*
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Cell Adhesion Molecules, Neuronal
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Cell Line
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Cell Membrane / metabolism
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Cytoplasm / metabolism
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Disks Large Homolog 4 Protein
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Guanylate Kinases
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Intercellular Junctions / metabolism
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism*
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Mice
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / metabolism*
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Neurons / metabolism*
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Nucleoside-Phosphate Kinase / metabolism
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Potassium Channels / metabolism
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Prosencephalon / metabolism*
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Receptors, N-Methyl-D-Aspartate / metabolism
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Recombinant Fusion Proteins / metabolism
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Tumor Suppressor Proteins
Substances
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Cell Adhesion Molecules, Neuronal
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Disks Large Homolog 4 Protein
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Dlg4 protein, mouse
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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Nerve Tissue Proteins
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Potassium Channels
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Receptors, N-Methyl-D-Aspartate
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Recombinant Fusion Proteins
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Tumor Suppressor Proteins
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neuroligin 1
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neuroligin 2
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neuroligin 3
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postsynaptic density proteins
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neurexin Ibeta
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CASK kinases
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Calcium-Calmodulin-Dependent Protein Kinases
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Nucleoside-Phosphate Kinase
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DLG2 protein, human
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Guanylate Kinases