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Estimation of glomerular filtration rate: does haemoglobin discriminate between ageing and true CKD?
Ferrari P, Xiao J, Ukich A, Irish A. Ferrari P, et al. Nephrol Dial Transplant. 2009 Jun;24(6):1828-33. doi: 10.1093/ndt/gfn738. Epub 2009 Jan 8. Nephrol Dial Transplant. 2009. PMID: 19131346
There was a negative relationship between age and median eGFR, and the slope of the regression line was -0.68 ml/min/year for males and -0.74 ml/min/year for females. ...Only an eGFR <45 ml/min/1.73 m(2) identified a smaller sub-group of older people with an incr …
There was a negative relationship between age and median eGFR, and the slope of the regression line was -0.68 ml/min/year for males a …
The effects of gemfibrozil upon the hypercoagulable state in dyslipidaemic patients with chronic renal failure.
Irish AB, Thompson CH. Irish AB, et al. Nephrol Dial Transplant. 1996 Nov;11(11):2223-8. doi: 10.1093/oxfordjournals.ndt.a027140. Nephrol Dial Transplant. 1996. PMID: 8941582
METHODS: We measured the coagulation activation marker prothrombin fragment F1 + 2 (F1 + 2), fibrinogen, plasminogen activator inhibitor-1 activity (PAI1), interleukin-6 (IL6), insulin, lipids and lipoprotein(a) (Lp(a)), in 12 patients with chronic renal disease bef …
METHODS: We measured the coagulation activation marker prothrombin fragment F1 + 2 (F1 + 2), fibrinogen, plasminogen activator inhibitor-1 a …
Factor VII coagulant activity (VIIc) and hypercoagulability in chronic renal disease and dialysis: relationship with dyslipidaemia, inflammation, and factor VII genotype.
Irish AB, Green FR. Irish AB, et al. Nephrol Dial Transplant. 1998 Mar;13(3):679-84. doi: 10.1093/ndt/13.3.679. Nephrol Dial Transplant. 1998. PMID: 9550647
Patients with CVD complications or a history of myocardial infarction did not have higher VIIc or F1+2 than those without CVD. ...Prospective studies are required to evaluate increased VIIc as a thrombotic risk factor in chronic renal disease....
Patients with CVD complications or a history of myocardial infarction did not have higher VIIc or F1+2 than those without CVD. ...Pro …
Renal allograft thrombosis: can thrombophilia explain the inexplicable?
Irish A. Irish A. Nephrol Dial Transplant. 1999 Oct;14(10):2297-303. doi: 10.1093/ndt/14.10.2297. Nephrol Dial Transplant. 1999. PMID: 10528648 Review.
Renal allograft thrombosis remains a preventable cause of early allograft thrombosis. It should not be considered simply an unpredictable and poorly understood consequence of surgery. ...The contribution of thrombophilia to non-immune mechanisms of chronic allograft loss i …
Renal allograft thrombosis remains a preventable cause of early allograft thrombosis. It should not be considered simply an unpredict …
Oxidant stress in nephrotic syndrome: comparison of F(2)-isoprostanes and plasma antioxidant potential.
Dogra G, Ward N, Croft KD, Mori TA, Barrett PH, Herrmann SE, Irish AB, Watts GF. Dogra G, et al. Nephrol Dial Transplant. 2001 Aug;16(8):1626-30. doi: 10.1093/ndt/16.8.1626. Nephrol Dial Transplant. 2001. PMID: 11477165
The plasma ORAC assay measured the decrease in fluorescence of phycoerythrin added to plasma in the presence of a free-radical generator. The ORAC value (microM) was calculated as the ratio of the area under the fluorescence decay curve for plasma to the area under the flu …
The plasma ORAC assay measured the decrease in fluorescence of phycoerythrin added to plasma in the presence of a free-radical genera …
Insulin resistance, dyslipidaemia, inflammation and endothelial function in nephrotic syndrome.
Dogra GK, Herrmann S, Irish AB, Thomas MA, Watts GF. Dogra GK, et al. Nephrol Dial Transplant. 2002 Dec;17(12):2220-5. doi: 10.1093/ndt/17.12.2220. Nephrol Dial Transplant. 2002. PMID: 12454236
Despite significantly lower plasma NEFAs in NS, the NEFA:albumin ratio showed a non-significant trend to higher levels in NS (NS 10.7+/-0.1 micro mol/g, CS 8.7+/-0.1 micro mol/g, P=0.06). ...
Despite significantly lower plasma NEFAs in NS, the NEFA:albumin ratio showed a non-significant trend to higher levels in NS (NS 10.7 …
Hypercoagulability in renal transplant recipients. Identifying patients at risk of renal allograft thrombosis and evaluating strategies for prevention.
Irish A. Irish A. Am J Cardiovasc Drugs. 2004;4(3):139-49. doi: 10.2165/00129784-200404030-00001. Am J Cardiovasc Drugs. 2004. PMID: 15134466 Review.
Early allograft loss, due to acute thrombotic complications, remains a constant and proportionally increasing complication of renal transplantation. ...In unselected patients at low clinical risk, aspirin (75-150 mg/day) with or without a short period of unfractiona …
Early allograft loss, due to acute thrombotic complications, remains a constant and proportionally increasing complication of renal t …
Efficacy and safety of oral versus intravenous ascorbic acid for anaemia in haemodialysis patients.
Chan D, Irish A, Dogra G. Chan D, et al. Nephrology (Carlton). 2005 Aug;10(4):336-40. doi: 10.1111/j.1440-1797.2005.00424.x. Nephrology (Carlton). 2005. PMID: 16109077 Clinical Trial.
In the second study, oral AA had no effect on Hb, rEPO dose and ferritin in the whole group and a subgroup of 30 with anaemia. ...AA in this select small group of iron-overloaded haemodialysis patients or in a larger population of haemodialysis patients given oral A …
In the second study, oral AA had no effect on Hb, rEPO dose and ferritin in the whole group and a subgroup of 30 with anaemia. ...AA …
Effect of ascorbic acid supplementation on plasma isoprostanes in haemodialysis patients.
Chan D, Irish A, Croft KD, Dogra G. Chan D, et al. Nephrol Dial Transplant. 2006 Jan;21(1):234-5. doi: 10.1093/ndt/gfi154. Epub 2005 Oct 4. Nephrol Dial Transplant. 2006. PMID: 16204285 Clinical Trial. No abstract available.
Insulin resistance, inflammation, and blood pressure determine vascular dysfunction in CKD.
Dogra G, Irish A, Chan D, Watts G. Dogra G, et al. Am J Kidney Dis. 2006 Dec;48(6):926-34. doi: 10.1053/j.ajkd.2006.08.008. Am J Kidney Dis. 2006. PMID: 17162147
BACKGROUND: Conventional cardiovascular risk equations underestimate the risk for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD), implying a role for novel risk factors. ...
BACKGROUND: Conventional cardiovascular risk equations underestimate the risk for cardiovascular disease (CVD) in patients with chronic kidn …
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