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Mitochondrial biogenesis and healthy aging.
López-Lluch G, Irusta PM, Navas P, de Cabo R. López-Lluch G, et al. Among authors: irusta pm. Exp Gerontol. 2008 Sep;43(9):813-9. doi: 10.1016/j.exger.2008.06.014. Epub 2008 Jul 9. Exp Gerontol. 2008. PMID: 18662766 Free PMC article. Review.
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.
Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI. Birkenfeld AL, et al. Among authors: irusta pm. Cell Metab. 2011 Aug 3;14(2):184-95. doi: 10.1016/j.cmet.2011.06.009. Cell Metab. 2011. PMID: 21803289 Free PMC article.
Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro.
de Cabo R, Liu L, Ali A, Price N, Zhang J, Wang M, Lakatta E, Irusta PM. de Cabo R, et al. Among authors: irusta pm. Aging (Albany NY). 2015 Mar;7(3):152-66. doi: 10.18632/aging.100719. Aging (Albany NY). 2015. PMID: 25855056 Free PMC article.
Bacterial lysates improve the protective antibody response against respiratory viruses through Toll-like receptor 4.
Coviello S, Wimmenauer V, Polack FP, Irusta PM. Coviello S, et al. Among authors: irusta pm. Hum Vaccin Immunother. 2014;10(10):2896-902. doi: 10.4161/hv.29784. Epub 2014 Nov 19. Hum Vaccin Immunother. 2014. PMID: 25483455 Free PMC article.
The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential.
Melzer IM, Fernández SB, Bösser S, Lohrig K, Lewandrowski U, Wolters D, Kehrloesser S, Brezniceanu ML, Theos AC, Irusta PM, Impens F, Gevaert K, Zörnig M. Melzer IM, et al. Among authors: irusta pm. Cell Death Differ. 2012 Sep;19(9):1435-45. doi: 10.1038/cdd.2012.17. Epub 2012 Mar 2. Cell Death Differ. 2012. PMID: 22388353 Free PMC article.
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Among authors: irusta pm. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.
Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven.
Zou S, Chang J, LaFever L, Tang W, Johnson EL, Hu J, Wilk R, Krause HM, Drummond-Barbosa D, Irusta PM. Zou S, et al. Among authors: irusta pm. Cell Cycle. 2011 Mar 15;10(6):989-98. doi: 10.4161/cc.10.6.15080. Epub 2011 Mar 15. Cell Cycle. 2011. PMID: 21368576 Free PMC article.
Conserved cysteine residues within the attachment G glycoprotein of respiratory syncytial virus play a critical role in the enhancement of cytotoxic T-lymphocyte responses.
Melendi GA, Bridget D, Monsalvo AC, Laham FF, Acosta P, Delgado MF, Polack FP, Irusta PM. Melendi GA, et al. Among authors: irusta pm. Virus Genes. 2011 Feb;42(1):46-54. doi: 10.1007/s11262-010-0545-9. Epub 2010 Nov 4. Virus Genes. 2011. PMID: 21053062 Free PMC article.
Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
Esmaili AM, Johnson EL, Thaivalappil SS, Kuhn HM, Kornbluth S, Irusta PM. Esmaili AM, et al. Among authors: irusta pm. Cell Cycle. 2010 Oct 1;9(19):3913-20. doi: 10.4161/cc.9.19.13138. Epub 2010 Oct 25. Cell Cycle. 2010. PMID: 20935510
Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.
Delgado MF, Coviello S, Monsalvo AC, Melendi GA, Hernandez JZ, Batalle JP, Diaz L, Trento A, Chang HY, Mitzner W, Ravetch J, Melero JA, Irusta PM, Polack FP. Delgado MF, et al. Among authors: irusta pm. Nat Med. 2009 Jan;15(1):34-41. doi: 10.1038/nm.1894. Epub 2008 Dec 14. Nat Med. 2009. PMID: 19079256 Free PMC article.
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