Irving JA - Search Results

1

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.

Irving JA, Pike RN, Dai W, Brömme D, Worrall DM, Silverman GA, Coetzer TH, Dennison C, Bottomley SP, Whisstock JC. Irving JA, et al. Biochemistry. 2002 Apr 16;41(15):4998-5004. doi: 10.1021/bi0159985. Biochemistry. 2002. PMID: 11939796

2

Serpins in the Caenorhabditis elegans genome.

Whisstock JC, Irving JA, Bottomley SP, Pike RN, Lesk AM. Whisstock JC, et al. Among authors: irving ja. Proteins. 1999 Jul 1;36(1):31-41. doi: 10.1002/(sici)1097-0134(19990701)36:1<31::aid-prot3>3.3.co;2-h. Proteins. 1999. PMID: 10373004

3

Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.

Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA. Luke C, et al. Among authors: irving ja. Biochemistry. 2000 Jun 20;39(24):7081-91. doi: 10.1021/bi000050g. Biochemistry. 2000. PMID: 10852705

4

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

Irving JA, Pike RN, Lesk AM, Whisstock JC. Irving JA, et al. Genome Res. 2000 Dec;10(12):1845-64. doi: 10.1101/gr.gr-1478r. Genome Res. 2000. PMID: 11116082 Free article.

5

Protein structural alignments and functional genomics.

Irving JA, Whisstock JC, Lesk AM. Irving JA, et al. Proteins. 2001 Feb 15;42(3):378-82. doi: 10.1002/1097-0134(20010215)42:3<378::aid-prot70>3.0.co;2-3. Proteins. 2001. PMID: 11151008

6

A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica.

Smooker PM, Whisstock JC, Irving JA, Siyaguna S, Spithill TW, Pike RN. Smooker PM, et al. Among authors: irving ja. Protein Sci. 2000 Dec;9(12):2567-72. doi: 10.1110/ps.9.12.2567. Protein Sci. 2000. PMID: 11206078 Free PMC article.

7

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.

Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. Silverman GA, et al. Among authors: irving ja. J Biol Chem. 2001 Sep 7;276(36):33293-6. doi: 10.1074/jbc.R100016200. Epub 2001 Jul 2. J Biol Chem. 2001. PMID: 11435447 Free article. Review. No abstract available.

8

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation.

Irving JA, Shushanov SS, Pike RN, Popova EY, Brömme D, Coetzer TH, Bottomley SP, Boulynko IA, Grigoryev SA, Whisstock JC. Irving JA, et al. J Biol Chem. 2002 Apr 12;277(15):13192-201. doi: 10.1074/jbc.M108460200. Epub 2002 Jan 30. J Biol Chem. 2002. PMID: 11821386 Free article.

9

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

Al-Khunaizi M, Luke CJ, Askew YS, Pak SC, Askew DJ, Cataltepe S, Miller D, Mills DR, Tsu C, Brömme D, Irving JA, Whisstock JC, Silverman GA. Al-Khunaizi M, et al. Among authors: irving ja. Biochemistry. 2002 Mar 5;41(9):3189-99. doi: 10.1021/bi015999x. Biochemistry. 2002. PMID: 11863458

10

Serpins: finely balanced conformational traps.

Pike RN, Bottomley SP, Irving JA, Bird PI, Whisstock JC. Pike RN, et al. Among authors: irving ja. IUBMB Life. 2002 Jul;54(1):1-7. doi: 10.1080/15216540213825. IUBMB Life. 2002. PMID: 12387568 Free article. Review.

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