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Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug.
Brennen WN, Rosen DM, Wang H, Isaacs JT, Denmeade SR. Brennen WN, et al. J Natl Cancer Inst. 2012 Sep 5;104(17):1320-34. doi: 10.1093/jnci/djs336. Epub 2012 Aug 21. J Natl Cancer Inst. 2012. PMID: 22911669 Free PMC article.
The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancer.
Denmeade SR, Isaacs JT. Denmeade SR, et al. Cancer Biol Ther. 2005 Jan;4(1):14-22. doi: 10.4161/cbt.4.1.1505. Epub 2005 Jan 23. Cancer Biol Ther. 2005. PMID: 15662118 Review.
Role of notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells.
Dalrymple S, Antony L, Xu Y, Uzgare AR, Arnold JT, Savaugeot J, Sokoll LJ, De Marzo AM, Isaacs JT. Dalrymple S, et al. Cancer Res. 2005 Oct 15;65(20):9269-79. doi: 10.1158/0008-5472.CAN-04-3989. Cancer Res. 2005. PMID: 16230388
Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells.
Vander Griend DJ, Antony L, Dalrymple SL, Xu Y, Christensen SB, Denmeade SR, Isaacs JT. Vander Griend DJ, et al. Mol Cancer Ther. 2009 May;8(5):1340-9. doi: 10.1158/1535-7163.MCT-08-1136. Epub 2009 May 5. Mol Cancer Ther. 2009. PMID: 19417145 Free PMC article.
Stabilizing androgen receptor in mitosis inhibits prostate cancer proliferation.
Vander Griend DJ, Litvinov IV, Isaacs JT. Vander Griend DJ, et al. Cell Cycle. 2007 Mar 15;6(6):647-51. doi: 10.4161/cc.6.6.4028. Epub 2007 Mar 21. Cell Cycle. 2007. PMID: 17387277 Review.
Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells.
Litvinov IV, Vander Griend DJ, Antony L, Dalrymple S, De Marzo AM, Drake CG, Isaacs JT. Litvinov IV, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15085-90. doi: 10.1073/pnas.0603057103. Epub 2006 Oct 2. Proc Natl Acad Sci U S A. 2006. PMID: 17015840 Free PMC article.
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