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Year Number of Results
1988 3
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1991 5
1992 4
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1994 2
1995 1
1996 2
1997 2
1998 2
1999 6
2000 4
2003 2
2004 4
2007 1
2008 1
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2010 1
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Page 1
The 5-HT1B receptors.
Middlemiss DN, Hutson PH. Middlemiss DN, et al. Ann N Y Acad Sci. 1990;600:132-47; discussion 347-48. doi: 10.1111/j.1749-6632.1990.tb16878.x. Ann N Y Acad Sci. 1990. PMID: 2252306 Review.
Antagonists at the 5-HT1B site include the drugs metitepin, metergoline, cyanopindolol, isamoltane, and propranolol but none of these drugs are selective for this receptor. ...
Antagonists at the 5-HT1B site include the drugs metitepin, metergoline, cyanopindolol, isamoltane, and propranolol but none of these …
Serotonin 5-HT1D receptors.
Hoyer D, Schoeffter P, Waeber C, Palacios JM. Hoyer D, et al. Ann N Y Acad Sci. 1990;600:168-81; discussion 181-2. doi: 10.1111/j.1749-6632.1990.tb16880.x. Ann N Y Acad Sci. 1990. PMID: 2252308 Review.
Rat 5-HT1B receptors recognize with high affinity a number of beta-adrenoceptor antagonists, such as SDZ 21-009, cyanopindolol, pindolol, propranolol and isamoltane. In contrast, calf, pig or human 5-HT1D receptors show significantly lower affinities for these drugs. 5-HT1 …
Rat 5-HT1B receptors recognize with high affinity a number of beta-adrenoceptor antagonists, such as SDZ 21-009, cyanopindolol, pindolol, pr …
Assessment of beta-adrenergic receptor blockade after isamoltane, a 5-HT1-receptor active compound, in healthy volunteers.
Bauer K, Dietersdorfer F, Kaik G. Bauer K, et al. Clin Pharmacol Ther. 1993 Jun;53(6):675-83. doi: 10.1038/clpt.1993.89. Clin Pharmacol Ther. 1993. PMID: 8099863 Clinical Trial.
The volunteers were given placebo, 4 mg isamoltane, 10 mg isamoltane, or 20 mg propranolol over a 7-day period in a randomized, double-blind, crossover design. ...Propranolol reduced exercise heart rate by 11% (compared with placebo), 10 mg isamoltane reduced …
The volunteers were given placebo, 4 mg isamoltane, 10 mg isamoltane, or 20 mg propranolol over a 7-day period in a randomized …
Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.
Waldmeier PC, Williams M, Baumann PA, Bischoff S, Sills MA, Neale RF. Waldmeier PC, et al. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun;337(6):609-20. doi: 10.1007/BF00175785. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2905765
The 5-HT1B activity of the compound resided in the (-)-enantiomer. (-)-Isamoltane had weak activity (IC50 3-10 mumol/l) at 5-HT2 and alpha 1-adrenoceptors. ...No changes in brain tryptophan levels were associated with the isamoltane-evoked changes in brain 5-HTP lev …
The 5-HT1B activity of the compound resided in the (-)-enantiomer. (-)-Isamoltane had weak activity (IC50 3-10 mumol/l) at 5-HT2 and …
Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain.
Rényi L, Larsson LG, Berg S, Svensson BE, Thorell G, Ross SB. Rényi L, et al. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jan;343(1):1-6. doi: 10.1007/BF00180669. Naunyn Schmiedebergs Arch Pharmacol. 1991. PMID: 1674359
Isamoltane increased the K(+)-evoked overflow of 3H from 3H-5-HT loaded slices of rat occipital cortex at 0.1 mumol/l, consistent with inhibition of the terminal 5-HT autoreceptor. ...Isamoltane at 3 mg/kg s.c. induced the wet-dog shake response which was blocked by …
Isamoltane increased the K(+)-evoked overflow of 3H from 3H-5-HT loaded slices of rat occipital cortex at 0.1 mumol/l, consistent wit …
Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices.
Davidson C, Stamford JA. Davidson C, et al. Brain Res Bull. 1997;43(4):405-9. doi: 10.1016/s0361-9230(97)00026-9. Brain Res Bull. 1997. PMID: 9241443
When given alone, neither the selective 5-HT 1B antagonist isamoltane (1 microM) nor the 5-HT 1D/B antagonist GR 127935 (50 nM), affected 5-HT efflux or uptake under this stimulation paradigm. When added in combination with paroxetine, both isamoltane and GR 127935 …
When given alone, neither the selective 5-HT 1B antagonist isamoltane (1 microM) nor the 5-HT 1D/B antagonist GR 127935 (50 nM), affe …
The role of 5-HT(1A) and 5-HT(1B/1D) receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (+/-)pindolol.
Dawson LA, Nguyen HQ. Dawson LA, et al. Neuropharmacology. 2000 Apr 3;39(6):1044-52. doi: 10.1016/s0028-3908(99)00192-6. Neuropharmacology. 2000. PMID: 10727715
In the present study, we compared the pharmacology of (+/-)pindolol, WAY-100635 (a 5-HT(1A) antagonist), GR127935 (a 5-HT(1B/1D) antagonist), and isamoltane (a 5-HT(1B) antagonist), when given acutely in combination with fluoxetine, using in vivo microdialysis in the front …
In the present study, we compared the pharmacology of (+/-)pindolol, WAY-100635 (a 5-HT(1A) antagonist), GR127935 (a 5-HT(1B/1D) antagonist) …
Differential effects of anxiolytics and beta-receptor blocking drugs on novelty-oriented ("neophobic") behavior in the rat.
Delini-Stula A, Hunn C. Delini-Stula A, et al. Pharmacopsychiatry. 1988 Jul;21(4):186-91. doi: 10.1055/s-2007-1014673. Pharmacopsychiatry. 1988. PMID: 2905063
The effects of diazepam, I-propranolol and isamoltane (CGP 361 A) (I-isopropylamino-3[2-(I-pyrrolyl)-phenoxy]-2-propranol), a drug with beta-receptor blocking and anxiolytic-like properties, on behavioral responses in rats encountering either a novel object or a drinking b …
The effects of diazepam, I-propranolol and isamoltane (CGP 361 A) (I-isopropylamino-3[2-(I-pyrrolyl)-phenoxy]-2-propranol), a drug wi …
Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.
Dias Elpo Zomkowski A, Oscar Rosa A, Lin J, Santos AR, Calixto JB, Lúcia Severo Rodrigues A. Dias Elpo Zomkowski A, et al. Brain Res. 2004 Oct 15;1023(2):253-63. doi: 10.1016/j.brainres.2004.07.041. Brain Res. 2004. PMID: 15374751
., a 5-HT(1A) receptor antagonist), 1-(2-(1-pyrrolyl)-phenoxy)-3-isopropylamino-2-propanol (isamoltane; 2.5 mg/kg, i.p., a 5-HT(1B) receptor antagonist), cyproheptadine (3 mg/kg, i.p., a 5-HT(2) antagonist) or ketanserin (5 mg/kg, i.p., a 5-HT(2A/2C) receptor antagonist), …
., a 5-HT(1A) receptor antagonist), 1-(2-(1-pyrrolyl)-phenoxy)-3-isopropylamino-2-propanol (isamoltane; 2.5 mg/kg, i.p., a 5-HT(1B) r …
Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5-HT1A and 5-HT1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181.
Hillegaart V, Ahlenius S. Hillegaart V, et al. Br J Pharmacol. 1998 Dec;125(8):1733-43. doi: 10.1038/sj.bjp.0702239. Br J Pharmacol. 1998. PMID: 9886765 Free PMC article.
The 5-HT1B receptor agonist anpirtoline (0.25-4.00 micromol kg(-1) s.c.) produced a dose-dependent inhibition of the male rat ejaculatory behaviour, and this effect was fully antagonized by pretreatment with the 5-HT1B receptor antagonist isamoltane (16 micromol kg(-1) s.c …
The 5-HT1B receptor agonist anpirtoline (0.25-4.00 micromol kg(-1) s.c.) produced a dose-dependent inhibition of the male rat ejaculatory be …
60 results