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Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations.
Morshead CM, Benveniste P, Iscove NN, van der Kooy D. Morshead CM, et al. Among authors: iscove nn. Nat Med. 2002 Mar;8(3):268-73. doi: 10.1038/nm0302-268. Nat Med. 2002. PMID: 11875498
Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.
Berger A, Benveniste P, Corfe SA, Tran AH, Barbara M, Wakeham A, Mak TW, Iscove NN, Paige CJ. Berger A, et al. Among authors: iscove nn. Blood. 2010 Nov 11;116(19):3792-801. doi: 10.1182/blood-2010-06-291062. Epub 2010 Jul 26. Blood. 2010. PMID: 20660792
Hematopoietic stem cells engraft in mice with absolute efficiency.
Benveniste P, Cantin C, Hyam D, Iscove NN. Benveniste P, et al. Among authors: iscove nn. Nat Immunol. 2003 Jul;4(7):708-13. doi: 10.1038/ni940. Epub 2003 May 25. Nat Immunol. 2003. PMID: 12766767
Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA.
Iscove NN, Barbara M, Gu M, Gibson M, Modi C, Winegarden N. Iscove NN, et al. Nat Biotechnol. 2002 Sep;20(9):940-3. doi: 10.1038/nbt729. Epub 2002 Aug 12. Nat Biotechnol. 2002. PMID: 12172558
Self-renewal as a therapeutic target in human colorectal cancer.
Kreso A, van Galen P, Pedley NM, Lima-Fernandes E, Frelin C, Davis T, Cao L, Baiazitov R, Du W, Sydorenko N, Moon YC, Gibson L, Wang Y, Leung C, Iscove NN, Arrowsmith CH, Szentgyorgyi E, Gallinger S, Dick JE, O'Brien CA. Kreso A, et al. Among authors: iscove nn. Nat Med. 2014 Jan;20(1):29-36. doi: 10.1038/nm.3418. Epub 2013 Dec 1. Nat Med. 2014. PMID: 24292392
GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.
Frelin C, Herrington R, Janmohamed S, Barbara M, Tran G, Paige CJ, Benveniste P, Zuñiga-Pflücker JC, Souabni A, Busslinger M, Iscove NN. Frelin C, et al. Among authors: iscove nn. Nat Immunol. 2013 Oct;14(10):1037-44. doi: 10.1038/ni.2692. Epub 2013 Aug 25. Nat Immunol. 2013. PMID: 23974957 Free PMC article.
Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.
Berger A, Frelin C, Shah DK, Benveniste P, Herrington R, Gerard NP, Zúñiga-Pflücker JC, Iscove NN, Paige CJ. Berger A, et al. Among authors: iscove nn. PLoS One. 2013;8(3):e58787. doi: 10.1371/journal.pone.0058787. Epub 2013 Mar 14. PLoS One. 2013. PMID: 23516556 Free PMC article.
Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.
Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G. Ting SB, et al. Among authors: iscove nn. Blood. 2012 Mar 15;119(11):2510-22. doi: 10.1182/blood-2011-11-393272. Epub 2011 Dec 14. Blood. 2012. PMID: 22174158
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.
Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G. Hope KJ, et al. Among authors: iscove nn. Cell Stem Cell. 2010 Jul 2;7(1):101-13. doi: 10.1016/j.stem.2010.06.007. Cell Stem Cell. 2010. PMID: 20621054
Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential.
Benveniste P, Frelin C, Janmohamed S, Barbara M, Herrington R, Hyam D, Iscove NN. Benveniste P, et al. Among authors: iscove nn. Cell Stem Cell. 2010 Jan 8;6(1):48-58. doi: 10.1016/j.stem.2009.11.014. Cell Stem Cell. 2010. PMID: 20074534
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