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Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae.
Yang HW, Fernando KHN, Oh JY, Li X, Jeon YJ, Ryu B. Yang HW, et al. Mar Drugs. 2019 Mar 29;17(4):202. doi: 10.3390/md17040202. Mar Drugs. 2019. PMID: 30934943 Free PMC article. Review.
Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement and exhibits various biological activities in vitro and in vivo. The bioactive compounds isolated from IO extract are known to possess anti- …
Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement …
Ishige okamurae Extract and Its Constituent Ishophloroglucin A Attenuated In Vitro and In Vivo High Glucose-Induced Angiogenesis.
Fernando KHN, Yang HW, Jiang Y, Jeon YJ, Ryu B. Fernando KHN, et al. Int J Mol Sci. 2019 Nov 6;20(22):5542. doi: 10.3390/ijms20225542. Int J Mol Sci. 2019. PMID: 31698871 Free PMC article.
Diabetes is associated with vascular complications, such as impaired wound healing and accelerated vascular growth. ...This study was performed to evaluate the effects of an extract of Ishige okamurae (IO) and its constituent, Ishophloroglucin A (IPA) on high glucos
Diabetes is associated with vascular complications, such as impaired wound healing and accelerated vascular growth. ...This study was
Ishige okamurae Extract Ameliorates the Hyperglycemia and Body Weight Gain of db/db Mice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21.
Seo YJ, Lee K, Chei S, Jeon YJ, Lee BY. Seo YJ, et al. Mar Drugs. 2019 Jul 9;17(7):407. doi: 10.3390/md17070407. Mar Drugs. 2019. PMID: 31323977 Free PMC article.
Type 2 diabetes mellitus and related metabolic disorders, such as dyslipidemia, present increasing challenges to health worldwide, as a result of urbanization, the increasing prevalence of obesity, poor lifestyle, and other stress-related factors. Ishige okam …
Type 2 diabetes mellitus and related metabolic disorders, such as dyslipidemia, present increasing challenges to health worldw …
Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-Induced Obese Mice.
Seo YJ, Lee K, Song JH, Chei S, Lee BY. Seo YJ, et al. Nutrients. 2018 Nov 20;10(11):1802. doi: 10.3390/nu10111802. Nutrients. 2018. PMID: 30463291 Free PMC article.
Obesity is caused by the expansion of white adipose tissue (WAT), which stores excess triacylglycerol (TG), this can lead to disorders including type 2 diabetes, atherosclerosis, metabolic diseases. Ishige okamurae extract (IOE) is prepared from a brown alga and has …
Obesity is caused by the expansion of white adipose tissue (WAT), which stores excess triacylglycerol (TG), this can lead to disorders inclu …
Effect of Ishophloroglucin A, A Component of Ishige okamurae, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice.
Yang HW, Son M, Choi J, Oh S, Jeon YJ, Byun K, Ryu B. Yang HW, et al. Mar Drugs. 2019 Oct 25;17(11):608. doi: 10.3390/md17110608. Mar Drugs. 2019. PMID: 31731426 Free PMC article.
Ishophloroglucin A (IPA), a component of Ishige okamurae (IO), was previously evaluated to standardize the antidiabetic potency of IO. However, the potential of IPA as a functional food for diabetes prevention has not yet been evaluated. Here, we investigated if 1.3 …
Ishophloroglucin A (IPA), a component of Ishige okamurae (IO), was previously evaluated to standardize the antidiabetic potency of IO …
Diphlorethohydroxycarmalol Isolated from Ishige okamurae Represses High Glucose-Induced Angiogenesis In Vitro and In Vivo.
Fernando KHN, Yang HW, Jiang Y, Jeon YJ, Ryu B. Fernando KHN, et al. Mar Drugs. 2018 Oct 10;16(10):375. doi: 10.3390/md16100375. Mar Drugs. 2018. PMID: 30308943 Free PMC article.
Diabetes mellitus causes abnormalities of angiogenesis leading to vascular dysfunction and serious pathologies. Diphlorethohydroxycarmalol (DPHC), which is isolated from Ishige okamurae, is well known for its bioactivities, including antihyperglycemic and pro
Diabetes mellitus causes abnormalities of angiogenesis leading to vascular dysfunction and serious pathologies. Diphlorethohyd
Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation.
Matsuda T, Kambe N, Ueki Y, Kanazawa N, Izawa K, Honda Y, Kawakami A, Takei S, Tonomura K, Inoue M, Kobayashi H, Okafuji I, Sakurai Y, Kato N, Maruyama Y, Inoue Y, Otsubo Y, Makino T, Okada S, Kobayashi I, Yashiro M, Ito S, Fujii H, Kondo Y, Okamoto N, Ito S, Iwata N, Kaneko U, Doi M, Hosokawa J, Ohara O, Saito MK, Nishikomori R; PIDJ members in the JSIAD; PIDJ (Primary Immunodeficiency and Autoinflammatory Diseases Database Project) members in the JSIAD (Japanese Society for Immunodeficiency and Autoinflammatory Diseases). Matsuda T, et al. Ann Rheum Dis. 2020 Nov;79(11):1492-1499. doi: 10.1136/annrheumdis-2020-217320. Epub 2020 Jul 9. Ann Rheum Dis. 2020. PMID: 32647028
Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice.
Min KH, Kim HJ, Jeon YJ, Han JS. Min KH, et al. Diabetes Res Clin Pract. 2011 Jul;93(1):70-6. doi: 10.1016/j.diabres.2011.03.018. Epub 2011 Apr 11. Diabetes Res Clin Pract. 2011. PMID: 21481483
We investigated the effect of Ishige okamurae extract on blood glucose level and insulin resistance in C57BL/-KsJ-db/db mice. ...After 6 weeks, blood glucose level was improved and blood glycosylated hemoglobin levels were lowered in sample group mice as compared to those …
We investigated the effect of Ishige okamurae extract on blood glucose level and insulin resistance in C57BL/-KsJ-db/db mice. ...Afte …
Octaphlorethol A: a potent alpha-glucosidase inhibitor isolated from Ishige foliacea shows an anti-hyperglycemic effect in mice with streptozotocin-induced diabetes.
Lee SH, Kang SM, Ko SC, Moon SH, Jeon BT, Lee DH, Jeon YJ. Lee SH, et al. Food Funct. 2014 Oct;5(10):2602-8. doi: 10.1039/c4fo00420e. Epub 2014 Aug 22. Food Funct. 2014. PMID: 25145393
Furthermore, increases in postprandial blood glucose levels were significantly suppressed in the OPA-treated group compared with those in the streptozotocin-induced diabetic or normal mice. Additionally, the area under the curve was significantly reduced following OPA admi …
Furthermore, increases in postprandial blood glucose levels were significantly suppressed in the OPA-treated group compared with those in th …
Octaphlorethol A, a novel phenolic compound isolated from a brown alga, Ishige foliacea, increases glucose transporter 4-mediated glucose uptake in skeletal muscle cells.
Lee SH, Kang SM, Ko SC, Lee DH, Jeon YJ. Lee SH, et al. Biochem Biophys Res Commun. 2012 Apr 13;420(3):576-81. doi: 10.1016/j.bbrc.2012.03.036. Epub 2012 Mar 15. Biochem Biophys Res Commun. 2012. PMID: 22445752
Promoting glucose uptake into this tissue may attenuate the insulin resistance that precedes type 2 diabetes. However, the anti-diabetic effect of marine algae on glucose uptake and metabolism in skeletal muscle remains poorly understood. ...In summary, PI3-K/Akt an …
Promoting glucose uptake into this tissue may attenuate the insulin resistance that precedes type 2 diabetes. However, the anti-di
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