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Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae.
Yang HW, Fernando KHN, Oh JY, Li X, Jeon YJ, Ryu B. Yang HW, et al. Mar Drugs. 2019 Mar 29;17(4):202. doi: 10.3390/md17040202. Mar Drugs. 2019. PMID: 30934943 Free PMC article. Review.
Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement and exhibits various biological activities in vitro and in vivo. The bioactive compounds isolated from IO extract are known to possess anti- …
Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement …
Ishige okamurae Ameliorates Methylglyoxal-Induced Nephrotoxicity via Reducing Oxidative Stress, RAGE Protein Expression, and Modulating MAPK, Nrf2/ARE Signaling Pathway in Mouse Glomerular Mesangial Cells.
Kim M, Cho C, Lee C, Ryu B, Kim S, Hur J, Lee SH. Kim M, et al. Foods. 2021 Aug 26;10(9):2000. doi: 10.3390/foods10092000. Foods. 2021. PMID: 34574110 Free PMC article.
Advanced glycation end-products (AGEs) such as methylglyoxal (MGO) play a vital role in the pathogenesis of nephropathy, a diabetic complication. In the present study, we evaluated the anti-glycation and renal protective properties of Ishige okamurae extract (IOE) a …
Advanced glycation end-products (AGEs) such as methylglyoxal (MGO) play a vital role in the pathogenesis of nephropathy, a diabetic c …
Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-Induced Obese Mice.
Seo YJ, Lee K, Song JH, Chei S, Lee BY. Seo YJ, et al. Nutrients. 2018 Nov 20;10(11):1802. doi: 10.3390/nu10111802. Nutrients. 2018. PMID: 30463291 Free PMC article.
Obesity is caused by the expansion of white adipose tissue (WAT), which stores excess triacylglycerol (TG), this can lead to disorders including type 2 diabetes, atherosclerosis, metabolic diseases. Ishige okamurae extract (IOE) is prepared from a brown alga and has …
Obesity is caused by the expansion of white adipose tissue (WAT), which stores excess triacylglycerol (TG), this can lead to disorders inclu …
Reversibility of sarcopenia by Ishige okamurae and its active derivative diphloroethohydroxycarmalol in female aging mice.
Hyun J, Ryu B, Oh S, Chung DM, Seo M, Park SJ, Byun K, Jeon YJ. Hyun J, et al. Biomed Pharmacother. 2022 Aug;152:113210. doi: 10.1016/j.biopha.2022.113210. Epub 2022 Jun 8. Biomed Pharmacother. 2022. PMID: 35689860 Free article.
Therefore, it is necessary to develop safe and biocompatible agents to treat age-related sarcopenia. Ishige okamurae (IO), an edible brown alga, and its active substance, diphloroethohydroxycarmalol (DPHC), have been reported to have various physiological functions, includ …
Therefore, it is necessary to develop safe and biocompatible agents to treat age-related sarcopenia. Ishige okamurae (IO), an edible …
Ishophloroglucin A, Isolated from Ishige okamurae, Alleviates Dexamethasone-Induced Muscle Atrophy through Muscle Protein Metabolism In Vivo.
Yang HW, Oh S, Chung DM, Seo M, Park SJ, Jeon YJ, Byun K, Ryu B. Yang HW, et al. Mar Drugs. 2022 Apr 22;20(5):280. doi: 10.3390/md20050280. Mar Drugs. 2022. PMID: 35621931 Free PMC article.
The in vitro capacity of Ishige okamurae extract (IO) to improve impaired muscle function has been previously examined. ...
The in vitro capacity of Ishige okamurae extract (IO) to improve impaired muscle function has been previously examined. ...
Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model.
Ryu B, Oh S, Yang HW, Sosorburam B, Chung DM, Seo M, Park SJ, Byun K, Jeon YJ. Ryu B, et al. Pharmaceutics. 2022 Mar 27;14(4):719. doi: 10.3390/pharmaceutics14040719. Pharmaceutics. 2022. PMID: 35456553 Free PMC article.
Muscle atrophy refers to the loss of skeletal muscle mass, myofiber size, and related physical functions such as walking speed or grip strength caused by aging or a lack of physical activity due to injury or illness and can also be attributed to excessive exposure to corticostero …
Muscle atrophy refers to the loss of skeletal muscle mass, myofiber size, and related physical functions such as walking speed or grip stren …
Diphlorethohydroxycarmalol Isolated from Ishige okamurae Represses High Glucose-Induced Angiogenesis In Vitro and In Vivo.
Fernando KHN, Yang HW, Jiang Y, Jeon YJ, Ryu B. Fernando KHN, et al. Mar Drugs. 2018 Oct 10;16(10):375. doi: 10.3390/md16100375. Mar Drugs. 2018. PMID: 30308943 Free PMC article.
Diabetes mellitus causes abnormalities of angiogenesis leading to vascular dysfunction and serious pathologies. Diphlorethohydroxycarmalol (DPHC), which is isolated from Ishige okamurae, is well known for its bioactivities, including antihyperglycemic and pro …
Diabetes mellitus causes abnormalities of angiogenesis leading to vascular dysfunction and serious pathologies. Diphlorethohyd …
Effect of Ishige okamurae extract on musculoskeletal biomarkers in adults with relative sarcopenia: Study protocol for a randomized double-blind placebo-controlled trial.
Lee SR, Lee YL, Lee SY. Lee SR, et al. Front Nutr. 2022 Sep 27;9:1015351. doi: 10.3389/fnut.2022.1015351. eCollection 2022. Front Nutr. 2022. PMID: 36238450 Free PMC article.
Many studies have been conducted to improve sarcopenia nutritionally. Ishige okamura (IO) is a genus of brown algae and plays a role in anti-diabetes, anti-obesity, and myogenesis. ...
Many studies have been conducted to improve sarcopenia nutritionally. Ishige okamura (IO) is a genus of brown algae and plays a role …
Ishige okamurae Extract and Its Constituent Ishophloroglucin A Attenuated In Vitro and In Vivo High Glucose-Induced Angiogenesis.
Fernando KHN, Yang HW, Jiang Y, Jeon YJ, Ryu B. Fernando KHN, et al. Int J Mol Sci. 2019 Nov 6;20(22):5542. doi: 10.3390/ijms20225542. Int J Mol Sci. 2019. PMID: 31698871 Free PMC article.
Diabetes is associated with vascular complications, such as impaired wound healing and accelerated vascular growth. ...This study was performed to evaluate the effects of an extract of Ishige okamurae (IO) and its constituent, Ishophloroglucin A (IPA) on high glucos …
Diabetes is associated with vascular complications, such as impaired wound healing and accelerated vascular growth. ...This study was …
Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation.
Matsuda T, Kambe N, Ueki Y, Kanazawa N, Izawa K, Honda Y, Kawakami A, Takei S, Tonomura K, Inoue M, Kobayashi H, Okafuji I, Sakurai Y, Kato N, Maruyama Y, Inoue Y, Otsubo Y, Makino T, Okada S, Kobayashi I, Yashiro M, Ito S, Fujii H, Kondo Y, Okamoto N, Ito S, Iwata N, Kaneko U, Doi M, Hosokawa J, Ohara O, Saito MK, Nishikomori R; PIDJ members in the JSIAD; PIDJ (Primary Immunodeficiency and Autoinflammatory Diseases Database Project) members in the JSIAD (Japanese Society for Immunodeficiency and Autoinflammatory Diseases). Matsuda T, et al. Ann Rheum Dis. 2020 Nov;79(11):1492-1499. doi: 10.1136/annrheumdis-2020-217320. Epub 2020 Jul 9. Ann Rheum Dis. 2020. PMID: 32647028
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