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Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB. Kirkpatrick CL, et al. Among authors: ishihara h. J Biol Chem. 2011 Sep 16;286(37):32300-12. doi: 10.1074/jbc.M111.247866. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784843 Free PMC article.
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.
Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, Tokita A, Satake C, Tashiro F, Katagiri H, Aburatani H, Miyazaki J, Oka Y. Yamada T, et al. Among authors: ishihara h. Hum Mol Genet. 2006 May 15;15(10):1600-9. doi: 10.1093/hmg/ddl081. Epub 2006 Mar 28. Hum Mol Genet. 2006. PMID: 16571599
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