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Targeting oncoproteins with a positive selection assay for protein degraders.
Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG Jr. Koduri V, et al. Among authors: ishoey m. Sci Adv. 2021 Feb 5;7(6):eabd6263. doi: 10.1126/sciadv.abd6263. Print 2021 Feb. Sci Adv. 2021. PMID: 33547076 Free PMC article.
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES. Nowak RP, et al. Among authors: ishoey m. Nat Chem Biol. 2018 Jul;14(7):706-714. doi: 10.1038/s41589-018-0055-y. Epub 2018 Jun 11. Nat Chem Biol. 2018. PMID: 29892083 Free PMC article.
Ligand-Promoted Meta-C-H Arylation of Anilines, Phenols, and Heterocycles.
Wang P, Farmer ME, Huo X, Jain P, Shen PX, Ishoey M, Bradner JE, Wisniewski SR, Eastgate MD, Yu JQ. Wang P, et al. Among authors: ishoey m. J Am Chem Soc. 2016 Jul 27;138(29):9269-76. doi: 10.1021/jacs.6b04966. Epub 2016 Jul 19. J Am Chem Soc. 2016. PMID: 27384126 Free PMC article.