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Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria.
Brähler S, Ising C, Hagmann H, Rasmus M, Hoehne M, Kurschat C, Kisner T, Goebel H, Shankland S, Addicks K, Thaiss F, Schermer B, Pasparakis M, Benzing T, Brinkkoetter PT. Brähler S, et al. Among authors: ising c. Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1473-85. doi: 10.1152/ajprenal.00031.2012. Epub 2012 Sep 12. Am J Physiol Renal Physiol. 2012. PMID: 22975019 Free article.
The role of the podocyte in albumin filtration.
Brinkkoetter PT, Ising C, Benzing T. Brinkkoetter PT, et al. Among authors: ising c. Nat Rev Nephrol. 2013 Jun;9(6):328-36. doi: 10.1038/nrneph.2013.78. Epub 2013 Apr 23. Nat Rev Nephrol. 2013. PMID: 23609563 Review.
Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.
Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT. Ising C, et al. EMBO Mol Med. 2015 Mar;7(3):275-87. doi: 10.15252/emmm.201404916. EMBO Mol Med. 2015. PMID: 25643582 Free PMC article.
The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.
Brähler S, Ising C, Barrera Aranda B, Höhne M, Schermer B, Benzing T, Brinkkoetter PT. Brähler S, et al. Among authors: ising c. Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F617-26. doi: 10.1152/ajprenal.00059.2015. Epub 2015 Aug 12. Am J Physiol Renal Physiol. 2015. PMID: 26268269 Free article.
As previously published, genetic inhibition of the NF-kappaB essential modulator (NEMO) in podocytes does not affect glomerular function under physiological, nonstressed conditions nor does it alter the initial podocyte response in an experimental glomerulonephritis (NTN) model ( …
As previously published, genetic inhibition of the NF-kappaB essential modulator (NEMO) in podocytes does not affect glomerular function und …
Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.
Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB. Brinkkoetter PT, et al. Among authors: ising c. Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012. Cell Rep. 2019. PMID: 31042480 Free PMC article.
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