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Page 1
Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.
Ristow M, Mulder H, Pomplun D, Schulz TJ, Müller-Schmehl K, Krause A, Fex M, Puccio H, Müller J, Isken F, Spranger J, Müller-Wieland D, Magnuson MA, Möhlig M, Koenig M, Pfeiffer AF. Ristow M, et al. Among authors: isken f. J Clin Invest. 2003 Aug;112(4):527-34. doi: 10.1172/JCI18107. J Clin Invest. 2003. PMID: 12925693 Free PMC article.
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M. Thierbach R, et al. Among authors: isken f. Hum Mol Genet. 2005 Dec 15;14(24):3857-64. doi: 10.1093/hmg/ddi410. Epub 2005 Nov 8. Hum Mol Genet. 2005. PMID: 16278235
Activation of mitochondrial energy metabolism protects against cardiac failure.
Schulz TJ, Westermann D, Isken F, Voigt A, Laube B, Thierbach R, Kuhlow D, Zarse K, Schomburg L, Pfeiffer AF, Tschöpe C, Ristow M. Schulz TJ, et al. Among authors: isken f. Aging (Albany NY). 2010 Nov;2(11):843-53. doi: 10.18632/aging.100234. Aging (Albany NY). 2010. PMID: 21084725 Free PMC article.
A high normal TSH is associated with the metabolic syndrome.
Ruhla S, Weickert MO, Arafat AM, Osterhoff M, Isken F, Spranger J, Schöfl C, Pfeiffer AF, Möhlig M. Ruhla S, et al. Among authors: isken f. Clin Endocrinol (Oxf). 2010 May;72(5):696-701. doi: 10.1111/j.1365-2265.2009.03698.x. Clin Endocrinol (Oxf). 2010. PMID: 20447068
Annual change in insulin sensitivity.
Isken F, Abraham U, Weickert MO, Keyhani-Nejad F, Arafat AM, Spranger J, Pfeiffer AF, Möhlig M. Isken F, et al. Horm Metab Res. 2011 Sep;43(10):720-2. doi: 10.1055/s-0031-1286310. Epub 2011 Sep 19. Horm Metab Res. 2011. PMID: 21932177
A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects.
Weickert MO, Loeffelholz CV, Roden M, Chandramouli V, Brehm A, Nowotny P, Osterhoff MA, Isken F, Spranger J, Landau BR, Pfeiffer AF, Möhlig M. Weickert MO, et al. Among authors: isken f. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E1078-84. doi: 10.1152/ajpendo.00337.2007. Epub 2007 Aug 14. Am J Physiol Endocrinol Metab. 2007. PMID: 17698986 Free article. Clinical Trial.
32 results