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Who let the dogs out? The ever-present threat of autoreactive T cells.
Ehlers MR. Ehlers MR. Sci Immunol. 2018 Feb 2;3(20):eaar6602. doi: 10.1126/sciimmunol.aar6602. Epub 2018 Feb 2. Sci Immunol. 2018. PMID: 29429979 Review.
Islet-reactive cytotoxic CD8(+) T cells home to the pancreas in type 1 diabetes but circulate at similar frequencies in patients and healthy controls....
Islet-reactive cytotoxic CD8(+) T cells home to the pancreas in type 1 diabetes but
The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment.
Martinuzzi E, Novelli G, Scotto M, Blancou P, Bach JM, Chaillous L, Bruno G, Chatenoud L, van Endert P, Mallone R. Martinuzzi E, et al. Diabetes. 2008 May;57(5):1312-20. doi: 10.2337/db07-1594. Epub 2008 Feb 27. Diabetes. 2008. PMID: 18305140 Free article.
OBJECTIVE: Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. ...RESULTS: CD8(+) T-cell reactivities were less frequent at follow-up, as 28.6% of responses te …
OBJECTIVE: Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes
Characterization of anti-islet cytotoxic human T-cell clones from patients with type 1 diabetes mellitus.
Sobel DO, Creswell K. Sobel DO, et al. Autoimmunity. 2006 Jun;39(4):323-32. doi: 10.1080/08916930600720753. Autoimmunity. 2006. PMID: 16891221
To identify important anti-islet T-cells and their target antigen(s), we have isolated and characterized seventeen human T-cell clones which are reactive to an extract of rat insulinoma (RIN) cells from three children with new onset ty
To identify important anti-islet T-cells and their target antigen(s), we have isolated and characterized seventeen huma …
Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4high expression as a marker.
Lejon K, Fathman CG. Lejon K, et al. J Immunol. 1999 Nov 15;163(10):5708-14. J Immunol. 1999. PMID: 10553102 Free article.
As few as 500 CD4high islet-infiltrating CD4+ T cells transferred insulin-dependent diabetes mellitus to CD8 reconstituted NOD-SCID mice within 30 days of transfer. ...These data indicate that the precursor frequency of NOD islet- …
As few as 500 CD4high islet-infiltrating CD4+ T cells transferred insulin-dependent diabetes mellitus to CD8
Differences in adhesion markers, activation markers, and TcR in islet infiltrating vs. peripheral lymphocytes in the NOD mouse.
Goldrath AW, Barber L, Chen KE, Alters SE. Goldrath AW, et al. J Autoimmun. 1995 Apr;8(2):209-20. doi: 10.1006/jaut.1995.0016. J Autoimmun. 1995. PMID: 7612149
Insulin dependent diabetes mellitus (IDDM) in the non-obese diabetic (NOD) mouse is the result of a cellular mediated autoimmune event that destroys pancreatic islet beta cells. ...Significantly increased levels of CD4+CD8+ double-positive
Insulin dependent diabetes mellitus (IDDM) in the non-obese diabetic (NOD) mouse is the result of a cellular mediated a …