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Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia.
Losordo DW, Vale PR, Hendel RC, Milliken CE, Fortuin FD, Cummings N, Schatz RA, Asahara T, Isner JM, Kuntz RE. Losordo DW, et al. Circulation. 2002 Apr 30;105(17):2012-8. doi: 10.1161/01.cir.0000015982.70785.b7. Circulation. 2002. PMID: 11980678 Clinical Trial.
Myocardial gene therapy.
Isner JM. Isner JM. Nature. 2002 Jan 10;415(6868):234-9. doi: 10.1038/415234a. Nature. 2002. PMID: 11805848 Review.
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.
Kirchmair R, Walter DH, Ii M, Rittig K, Tietz AB, Murayama T, Emanueli C, Silver M, Wecker A, Amant C, Schratzberger P, Yoon YS, Weber A, Panagiotou E, Rosen KM, Bahlmann FH, Adelman LS, Weinberg DH, Ropper AH, Isner JM, Losordo DW. Kirchmair R, et al. Circulation. 2005 May 24;111(20):2662-70. doi: 10.1161/CIRCULATIONAHA.104.470849. Epub 2005 May 16. Circulation. 2005. PMID: 15897348
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia.
Kawamoto A, Tkebuchava T, Yamaguchi J, Nishimura H, Yoon YS, Milliken C, Uchida S, Masuo O, Iwaguro H, Ma H, Hanley A, Silver M, Kearney M, Losordo DW, Isner JM, Asahara T. Kawamoto A, et al. Among authors: isner jm. Circulation. 2003 Jan 28;107(3):461-8. doi: 10.1161/01.cir.0000046450.89986.50. Circulation. 2003. PMID: 12551872
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