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1,019 results
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Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria.
Ono T, Isobe K, Nakada K, Hayashi JI. Ono T, et al. Among authors: isobe k. Nat Genet. 2001 Jul;28(3):272-5. doi: 10.1038/90116. Nat Genet. 2001. PMID: 11431699
A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.
Tawata M, Hayashi JI, Isobe K, Ohkubo E, Ohtaka M, Chen J, Aida K, Onaya T. Tawata M, et al. Among authors: isobe k. Diabetes. 2000 Jul;49(7):1269-72. doi: 10.2337/diabetes.49.7.1269. Diabetes. 2000. PMID: 10909988
Transcomplementation between different types of respiration-deficient mitochondria with different pathogenic mutant mitochondrial DNAs.
Takai D, Isobe K, Hayashi J. Takai D, et al. Among authors: isobe k. J Biol Chem. 1999 Apr 16;274(16):11199-202. doi: 10.1074/jbc.274.16.11199. J Biol Chem. 1999. PMID: 10196206
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA.
Nakada K, Inoue K, Ono T, Isobe K, Ogura A, Goto YI, Nonaka I, Hayashi JI. Nakada K, et al. Among authors: isobe k. Nat Med. 2001 Aug;7(8):934-40. doi: 10.1038/90976. Nat Med. 2001. PMID: 11479626
Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function.
Aomi Y, Chen CS, Nakada K, Ito S, Isobe K, Murakami H, Kuno SY, Tawata M, Matsuoka R, Mizusawa H, Hayashi JI. Aomi Y, et al. Among authors: isobe k. Biochem Biophys Res Commun. 2001 Jan 12;280(1):265-73. doi: 10.1006/bbrc.2000.4113. Biochem Biophys Res Commun. 2001. PMID: 11162509
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes.
Inoue K, Nakada K, Ogura A, Isobe K, Goto Y, Nonaka I, Hayashi JI. Inoue K, et al. Among authors: isobe k. Nat Genet. 2000 Oct;26(2):176-81. doi: 10.1038/82826. Nat Genet. 2000. PMID: 11017072
Complete repopulation of mouse mitochondrial DNA-less cells with rat mitochondrial DNA restores mitochondrial translation but not mitochondrial respiratory function.
Yamaoka M, Isobe K, Shitara H, Yonekawa H, Miyabayashi S, Hayashi JI. Yamaoka M, et al. Among authors: isobe k. Genetics. 2000 May;155(1):301-7. Genetics. 2000. PMID: 10790404 Free PMC article.
Nuclear-recessive mutations of factors involved in mitochondrial translation are responsible for age-related respiration deficiency of human skin fibroblasts.
Isobe K, Ito S, Hosaka H, Iwamura Y, Kondo H, Kagawa Y, Hayashi JI. Isobe K, et al. J Biol Chem. 1998 Feb 20;273(8):4601-6. doi: 10.1074/jbc.273.8.4601. J Biol Chem. 1998. PMID: 9468517
Isolation and characterization of mitochondrial DNA-less lines from various mammalian cell lines by application of an anticancer drug, ditercalinium.
Inoue K, Takai D, Hosaka H, Ito S, Shitara H, Isobe K, LePecq JB, Segal-Bendirdjian E, Hayashi J. Inoue K, et al. Among authors: isobe k. Biochem Biophys Res Commun. 1997 Oct 9;239(1):257-60. doi: 10.1006/bbrc.1997.7446. Biochem Biophys Res Commun. 1997. PMID: 9345305
Mutant mtDNA at 1555 A to G in 12S rRNA gene and hypersusceptibility of mitochondrial translation to streptomycin can be co-transferred to rho 0 HeLa cells.
Inoue K, Takai D, Soejima A, Isobe K, Yamasoba T, Oka Y, Goto Y, Hayashi J. Inoue K, et al. Among authors: isobe k. Biochem Biophys Res Commun. 1996 Jun 25;223(3):496-501. doi: 10.1006/bbrc.1996.0923. Biochem Biophys Res Commun. 1996. PMID: 8687424
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