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Role of itraconazole metabolites in CYP3A4 inhibition.
Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE. Isoherranen N, et al. Drug Metab Dispos. 2004 Oct;32(10):1121-31. doi: 10.1124/dmd.104.000315. Epub 2004 Jul 8. Drug Metab Dispos. 2004. PMID: 15242978
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism.
Huang W, Lin YS, McConn DJ 2nd, Calamia JC, Totah RA, Isoherranen N, Glodowski M, Thummel KE. Huang W, et al. Among authors: isoherranen n. Drug Metab Dispos. 2004 Dec;32(12):1434-45. doi: 10.1124/dmd.104.001313. Epub 2004 Sep 21. Drug Metab Dispos. 2004. PMID: 15383492
Stereochemical aspects of itraconazole metabolism in vitro and in vivo.
Kunze KL, Nelson WL, Kharasch ED, Thummel KE, Isoherranen N. Kunze KL, et al. Among authors: isoherranen n. Drug Metab Dispos. 2006 Apr;34(4):583-90. doi: 10.1124/dmd.105.008508. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415110 Clinical Trial.
Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
Templeton IE, Thummel KE, Kharasch ED, Kunze KL, Hoffer C, Nelson WL, Isoherranen N. Templeton IE, et al. Among authors: isoherranen n. Clin Pharmacol Ther. 2008 Jan;83(1):77-85. doi: 10.1038/sj.clpt.6100230. Epub 2007 May 9. Clin Pharmacol Ther. 2008. PMID: 17495874 Free PMC article. Clinical Trial.
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