Isoherranen N - Search Results

1

Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data.

Isoherranen N, Lutz JD, Chung SP, Hachad H, Levy RH, Ragueneau-Majlessi I. Isoherranen N, et al. Chem Res Toxicol. 2012 Nov 19;25(11):2285-300. doi: 10.1021/tx300192g. Epub 2012 Sep 27. Chem Res Toxicol. 2012. PMID: 22823924 Free PMC article. Review.

2

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism.

Yabut KCB, Martynova A, Nath A, Zercher BP, Bush MF, Isoherranen N. Yabut KCB, et al. Among authors: isoherranen n. bioRxiv [Preprint]. 2024 Jan 19:2024.01.17.576032. doi: 10.1101/2024.01.17.576032. bioRxiv. 2024. Update in: Mol Pharmacol. 2024 May 17;105(6):395-410. doi: 10.1124/molpharm.124.000878. PMID: 38293009 Free PMC article. Updated. Preprint.

3

Analysis of topiramate and its metabolites in plasma and urine of healthy subjects and patients with epilepsy by use of a novel liquid chromatography-mass spectrometry assay.

Britzi M, Soback S, Isoherranen N, Levy RH, Perucca E, Doose DR, Maryanoff BE, Bialer M. Britzi M, et al. Among authors: isoherranen n. Ther Drug Monit. 2003 Jun;25(3):314-22. doi: 10.1097/00007691-200306000-00012. Ther Drug Monit. 2003. PMID: 12766560

4

Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites.

Isoherranen N, Levy RH, Yagen B, Woodhead JH, White HS, Bialer M. Isoherranen N, et al. Epilepsy Res. 2004 Jan;58(1):1-12. doi: 10.1016/j.eplepsyres.2003.12.001. Epilepsy Res. 2004. PMID: 15066669

5

Role of itraconazole metabolites in CYP3A4 inhibition.

Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE. Isoherranen N, et al. Drug Metab Dispos. 2004 Oct;32(10):1121-31. doi: 10.1124/dmd.104.000315. Epub 2004 Jul 8. Drug Metab Dispos. 2004. PMID: 15242978

6

Stereochemical aspects of itraconazole metabolism in vitro and in vivo.

Kunze KL, Nelson WL, Kharasch ED, Thummel KE, Isoherranen N. Kunze KL, et al. Among authors: isoherranen n. Drug Metab Dispos. 2006 Apr;34(4):583-90. doi: 10.1124/dmd.105.008508. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415110 Clinical Trial.

7

Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.

Templeton IE, Thummel KE, Kharasch ED, Kunze KL, Hoffer C, Nelson WL, Isoherranen N. Templeton IE, et al. Among authors: isoherranen n. Clin Pharmacol Ther. 2008 Jan;83(1):77-85. doi: 10.1038/sj.clpt.6100230. Epub 2007 May 9. Clin Pharmacol Ther. 2008. PMID: 17495874 Free PMC article. Clinical Trial.

8

The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation.

Isoherranen N, Ludington SR, Givens RC, Lamba JK, Pusek SN, Dees EC, Blough DK, Iwanaga K, Hawke RL, Schuetz EG, Watkins PB, Thummel KE, Paine MF. Isoherranen N, et al. Drug Metab Dispos. 2008 Jan;36(1):146-54. doi: 10.1124/dmd.107.018382. Epub 2007 Oct 22. Drug Metab Dispos. 2008. PMID: 17954524

9

Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy.

Dickmann LJ, Tay S, Senn TD, Zhang H, Visone A, Unadkat JD, Hebert MF, Isoherranen N. Dickmann LJ, et al. Among authors: isoherranen n. Biochem Pharmacol. 2008 Apr 15;75(8):1677-87. doi: 10.1016/j.bcp.2008.01.012. Epub 2008 Feb 7. Biochem Pharmacol. 2008. PMID: 18342837 Free PMC article.

10

Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.

Lutz JD, Dixit V, Yeung CK, Dickmann LJ, Zelter A, Thatcher JE, Nelson WL, Isoherranen N. Lutz JD, et al. Among authors: isoherranen n. Biochem Pharmacol. 2009 Jan 15;77(2):258-68. doi: 10.1016/j.bcp.2008.10.012. Epub 2008 Oct 17. Biochem Pharmacol. 2009. PMID: 18992717 Free PMC article.

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