Isoherranen N - Search Results

1

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification.

Sager JE, Yu J, Ragueneau-Majlessi I, Isoherranen N. Sager JE, et al. Among authors: isoherranen n. Drug Metab Dispos. 2015 Nov;43(11):1823-37. doi: 10.1124/dmd.115.065920. Epub 2015 Aug 21. Drug Metab Dispos. 2015. PMID: 26296709 Free PMC article.

2

Evidence of significant contribution from CYP3A5 to hepatic drug metabolism.

Huang W, Lin YS, McConn DJ 2nd, Calamia JC, Totah RA, Isoherranen N, Glodowski M, Thummel KE. Huang W, et al. Among authors: isoherranen n. Drug Metab Dispos. 2004 Dec;32(12):1434-45. doi: 10.1124/dmd.104.001313. Epub 2004 Sep 21. Drug Metab Dispos. 2004. PMID: 15383492

3

Stereochemical aspects of itraconazole metabolism in vitro and in vivo.

Kunze KL, Nelson WL, Kharasch ED, Thummel KE, Isoherranen N. Kunze KL, et al. Among authors: isoherranen n. Drug Metab Dispos. 2006 Apr;34(4):583-90. doi: 10.1124/dmd.105.008508. Epub 2006 Jan 13. Drug Metab Dispos. 2006. PMID: 16415110 Clinical Trial.

4

Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro.

Dai Y, Hebert MF, Isoherranen N, Davis CL, Marsh C, Shen DD, Thummel KE. Dai Y, et al. Among authors: isoherranen n. Drug Metab Dispos. 2006 May;34(5):836-47. doi: 10.1124/dmd.105.008680. Epub 2006 Feb 24. Drug Metab Dispos. 2006. PMID: 16501005

5

The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation.

Isoherranen N, Ludington SR, Givens RC, Lamba JK, Pusek SN, Dees EC, Blough DK, Iwanaga K, Hawke RL, Schuetz EG, Watkins PB, Thummel KE, Paine MF. Isoherranen N, et al. Drug Metab Dispos. 2008 Jan;36(1):146-54. doi: 10.1124/dmd.107.018382. Epub 2007 Oct 22. Drug Metab Dispos. 2008. PMID: 17954524

6

Qualitative analysis of the role of metabolites in inhibitory drug-drug interactions: literature evaluation based on the metabolism and transport drug interaction database.

Isoherranen N, Hachad H, Yeung CK, Levy RH. Isoherranen N, et al. Chem Res Toxicol. 2009 Feb;22(2):294-8. doi: 10.1021/tx800491e. Chem Res Toxicol. 2009. PMID: 19216580 Free PMC article. Review.

7

Rationalization and prediction of in vivo metabolite exposures: the role of metabolite kinetics, clearance predictions and in vitro parameters.

Lutz JD, Fujioka Y, Isoherranen N. Lutz JD, et al. Among authors: isoherranen n. Expert Opin Drug Metab Toxicol. 2010 Sep;6(9):1095-109. doi: 10.1517/17425255.2010.497487. Expert Opin Drug Metab Toxicol. 2010. PMID: 20557268 Free PMC article. Review.

8

Pregnancy decreases rat CYP1A2 activity and expression.

Walker AA, Dickmann L, Isoherranen N. Walker AA, et al. Among authors: isoherranen n. Drug Metab Dispos. 2011 Jan;39(1):4-7. doi: 10.1124/dmd.110.035766. Epub 2010 Oct 4. Drug Metab Dispos. 2011. PMID: 20921303 Free PMC article.

9

Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole.

Lutz JD, Isoherranen N. Lutz JD, et al. Among authors: isoherranen n. Drug Metab Dispos. 2012 Jan;40(1):159-68. doi: 10.1124/dmd.111.042200. Epub 2011 Oct 18. Drug Metab Dispos. 2012. PMID: 22010218 Free PMC article.

10

Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals.

Peng CC, Shi W, Lutz JD, Kunze KL, Liu JO, Nelson WL, Isoherranen N. Peng CC, et al. Among authors: isoherranen n. Drug Metab Dispos. 2012 Mar;40(3):426-35. doi: 10.1124/dmd.111.042739. Epub 2011 Nov 21. Drug Metab Dispos. 2012. PMID: 22106171 Free PMC article.

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