Isoherranen N - Search Results

1

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.

Wang H, Brown PC, Chow ECY, Ewart L, Ferguson SS, Fitzpatrick S, Freedman BS, Guo GL, Hedrich W, Heyward S, Hickman J, Isoherranen N, Li AP, Liu Q, Mumenthaler SM, Polli J, Proctor WR, Ribeiro A, Wang JY, Wange RL, Huang SM. Wang H, et al. Among authors: isoherranen n. Clin Transl Sci. 2021 Sep;14(5):1659-1680. doi: 10.1111/cts.13066. Epub 2021 Jun 16. Clin Transl Sci. 2021. PMID: 33982436 Free PMC article. Review.

2

Gut commensals expand vitamin A metabolic capacity of the mammalian host.

Bonakdar M, Czuba LC, Han G, Zhong G, Luong H, Isoherranen N, Vaishnava S. Bonakdar M, et al. Among authors: isoherranen n. Cell Host Microbe. 2022 Aug 10;30(8):1084-1092.e5. doi: 10.1016/j.chom.2022.06.011. Epub 2022 Jul 20. Cell Host Microbe. 2022. PMID: 35863343 Free PMC article.

3

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism.

Yabut KCB, Martynova A, Nath A, Zercher BP, Bush MF, Isoherranen N. Yabut KCB, et al. Among authors: isoherranen n. bioRxiv [Preprint]. 2024 Jan 19:2024.01.17.576032. doi: 10.1101/2024.01.17.576032. bioRxiv. 2024. PMID: 38293009 Free PMC article. Updated. Preprint.

4

CYP2D6 Activity Is Correlated with Changes in Plasma Concentrations of Taurocholic Acid during Pregnancy and Postpartum in CYP2D6 Extensive Metabolizers.

Czuba LC, Malhotra K, Enthoven L, Fay EE, Moreni SL, Mao J, Shi Y, Huang W, Totah RA, Isoherranen N, Hebert MF. Czuba LC, et al. Among authors: isoherranen n. Drug Metab Dispos. 2023 Nov;51(11):1474-1482. doi: 10.1124/dmd.123.001358. Epub 2023 Aug 7. Drug Metab Dispos. 2023. PMID: 37550070

5

Temporal changes in the systemic concentrations of retinoids in pregnant and postpartum women.

Jeong H, Armstrong AT, Isoherranen N, Czuba L, Yang A, Zumpf K, Ciolino J, Torres E, Stika CS, Wisner KL. Jeong H, et al. Among authors: isoherranen n. PLoS One. 2023 Feb 16;18(2):e0280424. doi: 10.1371/journal.pone.0280424. eCollection 2023. PLoS One. 2023. PMID: 36795769 Free PMC article.

6

Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug-Drug Interactions? Preclinical and Clinical Studies With 13-cis-Retinoic Acid.

Stevison F, Kosaka M, Kenny JR, Wong S, Hogarth C, Amory JK, Isoherranen N. Stevison F, et al. Among authors: isoherranen n. Clin Transl Sci. 2019 Jul;12(4):350-360. doi: 10.1111/cts.12616. Epub 2019 Mar 20. Clin Transl Sci. 2019. PMID: 30681285 Free PMC article. Clinical Trial.

7

Emerging Role of Organ-on-a-Chip Technologies in Quantitative Clinical Pharmacology Evaluation.

Isoherranen N, Madabushi R, Huang SM. Isoherranen N, et al. Clin Transl Sci. 2019 Mar;12(2):113-121. doi: 10.1111/cts.12627. Clin Transl Sci. 2019. PMID: 30740886 Free PMC article. Review.

8

Altered vitamin A metabolism in human liver slices corresponds to fibrogenesis.

Czuba LC, Wu X, Huang W, Hollingshead N, Roberto JB, Kenerson HL, Yeung RS, Crispe IN, Isoherranen N. Czuba LC, et al. Among authors: isoherranen n. Clin Transl Sci. 2021 May;14(3):976-989. doi: 10.1111/cts.12962. Epub 2021 Feb 2. Clin Transl Sci. 2021. PMID: 33382909 Free PMC article.

9

Do Inhibitory Metabolites Impact DDI Risk Assessment? Analysis of in vitro and in vivo Data from NDA Reviews Between 2013 and 2018.

Steinbronn C, Yang X, Yu J, Dimova H, Huang SM, Ragueneau-Majlessi I, Isoherranen N. Steinbronn C, et al. Among authors: isoherranen n. Clin Pharmacol Ther. 2021 Aug;110(2):452-463. doi: 10.1002/cpt.2259. Epub 2021 May 8. Clin Pharmacol Ther. 2021. PMID: 33835478 Free PMC article.

10

Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy.

Amaeze OU, Isoherranen N. Amaeze OU, et al. Among authors: isoherranen n. Clin Transl Sci. 2023 Nov;16(11):2163-2176. doi: 10.1111/cts.13614. Epub 2023 Sep 15. Clin Transl Sci. 2023. PMID: 37712488 Free PMC article.

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