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Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2.
Lassuthova P, Rebelo AP, Ravenscroft G, Lamont PJ, Davis MR, Manganelli F, Feely SM, Bacon C, Brožková DŠ, Haberlova J, Mazanec R, Tao F, Saghira C, Abreu L, Courel S, Powell E, Buglo E, Bis DM, Baxter MF, Ong RW, Marns L, Lee YC, Bai Y, Isom DG, Barro-Soria R, Chung KW, Scherer SS, Larsson HP, Laing NG, Choi BO, Seeman P, Shy ME, Santoro L, Zuchner S. Lassuthova P, et al. Among authors: isom dg. Am J Hum Genet. 2018 Mar 1;102(3):505-514. doi: 10.1016/j.ajhg.2018.01.023. Am J Hum Genet. 2018. PMID: 29499166 Free PMC article.
The evolution and mechanism of GPCR proton sensing.
Rowe JB, Kapolka NJ, Taghon GJ, Morgan WM, Isom DG. Rowe JB, et al. Among authors: isom dg. J Biol Chem. 2021 Jan-Jun;296:100167. doi: 10.1074/jbc.RA120.016352. Epub 2020 Dec 13. J Biol Chem. 2021. PMID: 33478938 Free PMC article.
HCAR3: an underexplored metabolite sensor.
Kapolka NJ, Isom DG. Kapolka NJ, et al. Among authors: isom dg. Nat Rev Drug Discov. 2020 Nov;19(11):745. doi: 10.1038/d41573-020-00173-2. Nat Rev Drug Discov. 2020. PMID: 33009526 Free PMC article. No abstract available.
Proton-gated coincidence detection is a common feature of GPCR signaling.
Kapolka NJ, Rowe JB, Taghon GJ, Morgan WM, O'Shea CR, Isom DG. Kapolka NJ, et al. Among authors: isom dg. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2100171118. doi: 10.1073/pnas.2100171118. Epub 2021 Jul 6. Proc Natl Acad Sci U S A. 2021. PMID: 34260394 Free PMC article.
Amino acid metabolites that regulate G protein signaling during osmotic stress.
Shellhammer JP, Morin-Kensicki E, Matson JP, Yin G, Isom DG, Campbell SL, Mohney RP, Dohlman HG. Shellhammer JP, et al. Among authors: isom dg. PLoS Genet. 2017 May 30;13(5):e1006829. doi: 10.1371/journal.pgen.1006829. eCollection 2017 May. PLoS Genet. 2017. PMID: 28558063 Free PMC article.
27 results