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A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency.
Courtois G, Smahi A, Reichenbach J, Döffinger R, Cancrini C, Bonnet M, Puel A, Chable-Bessia C, Yamaoka S, Feinberg J, Dupuis-Girod S, Bodemer C, Livadiotti S, Novelli F, Rossi P, Fischer A, Israël A, Munnich A, Le Deist F, Casanova JL. Courtois G, et al. Among authors: israel a. J Clin Invest. 2003 Oct;112(7):1108-15. doi: 10.1172/JCI18714. J Clin Invest. 2003. PMID: 14523047 Free PMC article.
Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization.
Agou F, Courtois G, Chiaravalli J, Baleux F, Coïc YM, Traincard F, Israël A, Véron M. Agou F, et al. Among authors: israel a. J Biol Chem. 2004 Dec 24;279(52):54248-57. doi: 10.1074/jbc.M406423200. Epub 2004 Oct 5. J Biol Chem. 2004. PMID: 15466857
NF-kappa B essential modulator/IKK-gamma (NEMO/IKK-gamma) plays a key role in the activation of the NF-kappa B pathway in response to proinflammatory stimuli. ...The minimal oligomerization domain of this protein consists of two coiled-coil subdomains named Coiled-coil 2 ( …
NF-kappa B essential modulator/IKK-gamma (NEMO/IKK-gamma) plays a key role in the activation of the NF-kappa B pathway in response to …
The IKK complex contributes to the induction of autophagy.
Criollo A, Senovilla L, Authier H, Maiuri MC, Morselli E, Vitale I, Kepp O, Tasdemir E, Galluzzi L, Shen S, Tailler M, Delahaye N, Tesniere A, De Stefano D, Younes AB, Harper F, Pierron G, Lavandero S, Zitvogel L, Israel A, Baud V, Kroemer G. Criollo A, et al. Among authors: israel a. EMBO J. 2010 Feb 3;29(3):619-31. doi: 10.1038/emboj.2009.364. Epub 2009 Dec 3. EMBO J. 2010. PMID: 19959994 Free PMC article.
From calcium to NF-kappa B signaling pathways in neurons.
Lilienbaum A, Israël A. Lilienbaum A, et al. Among authors: israel a. Mol Cell Biol. 2003 Apr;23(8):2680-98. doi: 10.1128/MCB.23.8.2680-2698.2003. Mol Cell Biol. 2003. PMID: 12665571 Free PMC article.
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Vinolo E, Sebban H, Chaffotte A, Israël A, Courtois G, Véron M, Agou F. Vinolo E, et al. Among authors: israel a. J Biol Chem. 2006 Mar 10;281(10):6334-48. doi: 10.1074/jbc.M510118200. Epub 2005 Dec 26. J Biol Chem. 2006. PMID: 16379012
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