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Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates.

Slingsby MHL, Vijey P, Tsai IT, Roweth H, Couldwell G, Wilkie AR, Gaus H, Goolsby JM, Okazaki R, Terkovich BE, Semple JW, Thon JN, Henry SP, Narayanan P, Italiano JE Jr. Slingsby MHL, et al. Among authors: italiano je jr. Haematologica. 2021 Feb 11. doi: 10.3324/haematol.2020.260059. Online ahead of print. Haematologica. 2021. PMID: 33567808 Free article.

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High-content, label-free analysis of proplatelet production from megakaryocytes.

French SL, Vijey P, Karhohs KW, Wilkie AR, Horin LJ, Ray A, Posorske B, Carpenter AE, Machlus KR, Italiano JE Jr. French SL, et al. Among authors: italiano je jr. J Thromb Haemost. 2020 Oct;18(10):2701-2711. doi: 10.1111/jth.15012. Epub 2020 Aug 23. J Thromb Haemost. 2020. PMID: 32662223 Free PMC article.

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Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood.

Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsey CR, Italiano JE Jr, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray PF. Bhatlekar S, et al. Among authors: italiano je jr. Haematologica. 2019 Oct;104(10):2075-2083. doi: 10.3324/haematol.2018.204685. Epub 2019 Feb 7. Haematologica. 2019. PMID: 30733267 Free PMC article.

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Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.

Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE Jr, Battinelli EM. Johnson KE, et al. Among authors: italiano je jr. Blood Adv. 2019 Jan 22;3(2):198-211. doi: 10.1182/bloodadvances.2018026161. Blood Adv. 2019. PMID: 30670536 Free PMC article.

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Unlocking the Molecular Secrete(s) of α-Granule Biogenesis.

Noetzli LJ, Italiano JE Jr. Noetzli LJ, et al. Among authors: italiano je jr. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2539-2541. doi: 10.1161/ATVBAHA.118.311614. Arterioscler Thromb Vasc Biol. 2018. PMID: 30354241 Free PMC article. No abstract available.

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Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE Jr, Semple JW. Zufferey A, et al. Among authors: italiano je jr. Blood Adv. 2017 Sep 8;1(20):1773-1785. doi: 10.1182/bloodadvances.2017007021. eCollection 2017 Sep 12. Blood Adv. 2017. PMID: 29296823 Free PMC article.

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Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.

Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W. Paul DS, et al. Among authors: italiano je jr. Blood Adv. 2017 Aug 8;1(18):1398-1408. doi: 10.1182/bloodadvances.2017006973. Blood Adv. 2017. PMID: 29104956 Free PMC article.

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Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.

Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE Jr, Landesman Y. Machlus KR, et al. Among authors: italiano je jr. Blood. 2017 Aug 31;130(9):1132-1143. doi: 10.1182/blood-2016-11-752840. Epub 2017 Jun 19. Blood. 2017. PMID: 28630120 Free PMC article. Clinical Trial.

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Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis.

Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE Jr, Battinelli EM. Johnson KE, et al. Among authors: italiano je jr. Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):664-674. doi: 10.1161/ATVBAHA.116.308791. Epub 2017 Feb 2. Arterioscler Thromb Vasc Biol. 2017. PMID: 28153880 Free PMC article.

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Human thrombopoiesis depends on Protein kinase Cδ/protein kinase Cε functional couple.

Carubbi C, Masselli E, Martini S, Galli D, Aversa F, Mirandola P, Italiano JE Jr, Gobbi G, Vitale M. Carubbi C, et al. Among authors: italiano je jr. Haematologica. 2016 Jul;101(7):812-20. doi: 10.3324/haematol.2015.137984. Epub 2016 Apr 14. Haematologica. 2016. PMID: 27081176 Free PMC article.

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