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ICOS is essential for effective T-helper-cell responses.
Tafuri A, Shahinian A, Bladt F, Yoshinaga SK, Jordana M, Wakeham A, Boucher LM, Bouchard D, Chan VS, Duncan G, Odermatt B, Ho A, Itie A, Horan T, Whoriskey JS, Pawson T, Penninger JM, Ohashi PS, Mak TW. Tafuri A, et al. Among authors: itie a. Nature. 2001 Jan 4;409(6816):105-9. doi: 10.1038/35051113. Nature. 2001. PMID: 11343123
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
Suh WK, Gajewska BU, Okada H, Gronski MA, Bertram EM, Dawicki W, Duncan GS, Bukczynski J, Plyte S, Elia A, Wakeham A, Itie A, Chung S, Da Costa J, Arya S, Horan T, Campbell P, Gaida K, Ohashi PS, Watts TH, Yoshinaga SK, Bray MR, Jordana M, Mak TW. Suh WK, et al. Among authors: itie a. Nat Immunol. 2003 Sep;4(9):899-906. doi: 10.1038/ni967. Epub 2003 Aug 17. Nat Immunol. 2003. PMID: 12925852
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV, Mak TW. Lomaga MA, et al. Among authors: itie a. Genes Dev. 1999 Apr 15;13(8):1015-24. doi: 10.1101/gad.13.8.1015. Genes Dev. 1999. PMID: 10215628 Free PMC article.
Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK. Kondo S, et al. Among authors: itie a. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5431-6. doi: 10.1073/pnas.0530308100. Epub 2003 Apr 17. Proc Natl Acad Sci U S A. 2003. PMID: 12702766 Free PMC article.
Generation and characterization of B7-H4/B7S1/B7x-deficient mice.
Suh WK, Wang S, Duncan GS, Miyazaki Y, Cates E, Walker T, Gajewska BU, Deenick E, Dawicki W, Okada H, Wakeham A, Itie A, Watts TH, Ohashi PS, Jordana M, Yoshida H, Mak TW. Suh WK, et al. Among authors: itie a. Mol Cell Biol. 2006 Sep;26(17):6403-11. doi: 10.1128/MCB.00755-06. Mol Cell Biol. 2006. PMID: 16914726 Free PMC article.
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