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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
Shweiki D, Itin A, Soffer D, Keshet E. Shweiki D, et al. Nature. 1992 Oct 29;359(6398):843-5. doi: 10.1038/359843a0. Nature. 1992. PMID: 1279431
Here we show that vascular endothelial growth factor (VEGF; also known as vascular permeability factor) probably functions as a hypoxia-inducible angiogenic factor. VEGF messenger RNA levels are dramatically increased within a few hours of exposing different cell cu …
Here we show that vascular endothelial growth factor (VEGF; also known as vascular permeability factor) probably functions as a hypox …
A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia.
Sela S, Itin A, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Yagel S, Keshet E. Sela S, et al. Among authors: itin a. Circ Res. 2008 Jun 20;102(12):1566-74. doi: 10.1161/CIRCRESAHA.108.171504. Epub 2008 May 30. Circ Res. 2008. PMID: 18515749
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation.
May D, Gilon D, Djonov V, Itin A, Lazarus A, Gordon O, Rosenberger C, Keshet E. May D, et al. Among authors: itin a. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):282-7. doi: 10.1073/pnas.0707778105. Epub 2007 Dec 27. Proc Natl Acad Sci U S A. 2008. PMID: 18162550 Free PMC article.
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells.
Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Jung S, Chimenti S, Landsman L, Abramovitch R, Keshet E. Grunewald M, et al. Among authors: itin a. Cell. 2006 Jan 13;124(1):175-89. doi: 10.1016/j.cell.2005.10.036. Cell. 2006. PMID: 16413490 Free article.
Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer.
May D, Itin A, Gal O, Kalinski H, Feinstein E, Keshet E. May D, et al. Among authors: itin a. Oncogene. 2005 Feb 3;24(6):1011-20. doi: 10.1038/sj.onc.1208325. Oncogene. 2005. PMID: 15592500
Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy.
Dor Y, Djonov V, Abramovitch R, Itin A, Fishman GI, Carmeliet P, Goelman G, Keshet E. Dor Y, et al. EMBO J. 2002 Apr 15;21(8):1939-47. doi: 10.1093/emboj/21.8.1939. EMBO J. 2002. PMID: 11953313 Free PMC article.
Using this system, we demonstrate a progressive, unlimited ramification of the existing vasculature. In the absence of spatial cues, however, abnormal vascular trees were produced, a consequence of chaotic connections with the existing network and formation of irreg …
Using this system, we demonstrate a progressive, unlimited ramification of the existing vasculature. In the absence of spatial cues, …
Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies.
Porat RM, Grunewald M, Globerman A, Itin A, Barshtein G, Alhonen L, Alitalo K, Keshet E. Porat RM, et al. Circ Res. 2004 Feb 20;94(3):394-401. doi: 10.1161/01.RES.0000111803.92923.D6. Epub 2003 Dec 11. Circ Res. 2004. PMID: 14670840
Disturbance of laminar flow by a surgical interposition of a vein into an artery led to induction of tie1, specifically in the region where the differently sized vessels adjoin. ...Hemodynamic features of atherosclerotic lesion-prone regions, recreated in vitro with …
Disturbance of laminar flow by a surgical interposition of a vein into an artery led to induction of tie1, specifically in the …
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects.
Dor Y, Camenisch TD, Itin A, Fishman GI, McDonald JA, Carmeliet P, Keshet E. Dor Y, et al. Development. 2001 May;128(9):1531-8. Development. 2001. PMID: 11290292
To model hypoxia-dependent induction of VEGF in vivo, we conditionally induced VEGF expression in the myocardium using a tetracycline-regulated transgenic system. ...Together, these results suggest a novel developmental role for VEGF as a negative regulator o …
To model hypoxia-dependent induction of VEGF in vivo, we conditionally induced VEGF expression in the myocardium using a tetracycline …
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.
Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Benjamin LE, et al. J Clin Invest. 1999 Jan;103(2):159-65. doi: 10.1172/JCI5028. J Clin Invest. 1999. PMID: 9916127 Free PMC article.
We show that blood vessels in both a xenografted tumor and primary human tumors contain a sizable fraction of immature blood vessels that have not yet recruited periendothelial cells. ...In a xenografted glioma, the selective vulnerability of immature vessels …
We show that blood vessels in both a xenografted tumor and primary human tumors contain a sizable fraction of immature blood v …
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