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Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease.
Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo JS, Higasa K, Iwasaki M, Yamaji T, Sawada N, Tsugane S, Koyama T, Ikezaki H, Takashima N, Tanaka K, Arisawa K, Kuriki K, Naito M, Wakai K, Suna S, Sakata Y, Sato H, Hori M, Sakata Y, Matsuda K, Murakami Y, Aburatani H, Kubo M, Matsuda F, Kamatani Y, Komuro I. Koyama S, et al. Among authors: ito k. Nat Genet. 2020 Nov;52(11):1169-1177. doi: 10.1038/s41588-020-0705-3. Epub 2020 Oct 5. Nat Genet. 2020. PMID: 33020668
PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I. Ito K, et al. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8689-94. doi: 10.1073/pnas.0900064106. Epub 2009 May 8. Proc Natl Acad Sci U S A. 2009. PMID: 19429709 Free PMC article.
Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice.
Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Paradis P, Nemer M, Komuro I. Yasuda N, et al. Among authors: ito k. Hypertension. 2012 Mar;59(3):627-33. doi: 10.1161/HYPERTENSIONAHA.111.175208. Epub 2012 Jan 30. Hypertension. 2012. PMID: 22291447
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