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Covalent coercion by Legionella pneumophila.
Itzen A, Goody RS. Itzen A, et al. Cell Host Microbe. 2011 Aug 18;10(2):89-91. doi: 10.1016/j.chom.2011.08.002. Cell Host Microbe. 2011. PMID: 21843863
., 2011; Tan and Luo, 2011) and a new posttranslational modification (phosphocholination) of Rab1 (Mukherjee et al., 2011) have been reported....
., 2011; Tan and Luo, 2011) and a new posttranslational modification (phosphocholination) of Rab1 (Mukherjee et al., 2011) have been …
RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity.
Schoebel S, Oesterlin LK, Blankenfeldt W, Goody RS, Itzen A. Schoebel S, et al. Mol Cell. 2009 Dec 25;36(6):1060-72. doi: 10.1016/j.molcel.2009.11.014. Mol Cell. 2009. PMID: 20064470
Here, we present the crystal structure of a complex between the GEF domain of DrrA and Rab1 and a detailed kinetic analysis of this exchange. ...Thus, apparent GDI displacement by DrrA is linked directly to nucleotide exchange, suggesting a basic model for GD …
Here, we present the crystal structure of a complex between the GEF domain of DrrA and Rab1 and a detailed kinetic analysis of …
High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA.
Schoebel S, Blankenfeldt W, Goody RS, Itzen A. Schoebel S, et al. EMBO Rep. 2010 Aug;11(8):598-604. doi: 10.1038/embor.2010.97. Epub 2010 Jul 9. EMBO Rep. 2010. PMID: 20616805 Free PMC article.
In this study, we present the atomic structure of the PtdIns(4)P-binding domain of a protein (DrrA) from a human pathogen. A detailed kinetic investigation of its interaction with PtdIns(4)P reveals that DrrA binds to this phospholipid with, as yet unpreceden …
In this study, we present the atomic structure of the PtdIns(4)P-binding domain of a protein (DrrA) from a human pathogen. …
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.
Müller MP, Peters H, Blümer J, Blankenfeldt W, Goody RS, Itzen A. Müller MP, et al. Science. 2010 Aug 20;329(5994):946-9. doi: 10.1126/science.1192276. Epub 2010 Jul 22. Science. 2010. PMID: 20651120
In order to accomplish this, the Legionella protein DrrA contains a specific guanine nucleotide exchange activity for Rab1 activation that exchanges guanosine triphosphate (GTP) for guanosine diphosphate on Rab1. ...
In order to accomplish this, the Legionella protein DrrA contains a specific guanine nucleotide exchange activity for Rab1 activation …
GTPases involved in vesicular trafficking: structures and mechanisms.
Itzen A, Goody RS. Itzen A, et al. Semin Cell Dev Biol. 2011 Feb;22(1):48-56. doi: 10.1016/j.semcdb.2010.10.003. Epub 2010 Oct 15. Semin Cell Dev Biol. 2011. PMID: 20951823 Review.
Adenylylation: renaissance of a forgotten post-translational modification.
Itzen A, Blankenfeldt W, Goody RS. Itzen A, et al. Trends Biochem Sci. 2011 Apr;36(4):221-8. doi: 10.1016/j.tibs.2010.12.004. Epub 2011 Jan 20. Trends Biochem Sci. 2011. PMID: 21256032 Review.
The stable post-translational modification of proteins by adenylylation or uridylylation was discovered more than four decades ago as a mechanism to regulate the activity of enzymes. ...We present a survey of the historical and modern phases of research in this area …
The stable post-translational modification of proteins by adenylylation or uridylylation was discovered more than four decades ago as a
The versatile Legionella effector protein DrrA.
Goody RS, Müller MP, Schoebel S, Oesterlin LK, Blümer J, Peters H, Blankenfeldt W, Itzen A. Goody RS, et al. Commun Integr Biol. 2011 Jan;4(1):72-4. doi: 10.4161/cib.4.1.13857. Commun Integr Biol. 2011. PMID: 21509184 Free PMC article.
The human pathogen Legionella pneumophila is a bacterium that infects human cells and interferes with intracellular signaling. ...After depositing Rab1 at the LCV, DrrA covalently modifies Rab1 with an AMP moiety at a specific tyrosine residue (Tyr77), which is cent …
The human pathogen Legionella pneumophila is a bacterium that infects human cells and interferes with intracellular signaling. ...Aft …
Protein LidA from Legionella is a Rab GTPase supereffector.
Schoebel S, Cichy AL, Goody RS, Itzen A. Schoebel S, et al. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17945-50. doi: 10.1073/pnas.1113133108. Epub 2011 Oct 19. Proc Natl Acad Sci U S A. 2011. PMID: 22011575 Free PMC article.
One of these proteins, LidA, has been described as a Rab effector (i.e., a molecule that interacts preferentially with the GTP-bound form of Rab). ...Rab1b and Rab8a appear to bind LidA with K(d) values in the low picomolar range, making LidA a Rab supereffec …
One of these proteins, LidA, has been described as a Rab effector (i.e., a molecule that interacts preferentially with the GTP …
Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins.
Goody PR, Heller K, Oesterlin LK, Müller MP, Itzen A, Goody RS. Goody PR, et al. EMBO J. 2012 Apr 4;31(7):1774-84. doi: 10.1038/emboj.2012.16. Epub 2012 Feb 3. EMBO J. 2012. PMID: 22307087 Free PMC article.
The Legionella pneumophila protein AnkX that is injected into infected cells by a Type IV secretion system transfers a phosphocholine group from CDP-choline to a serine in the Rab1 and Rab35 GTPase Switch II regions. ...We present a model in which the …
The Legionella pneumophila protein AnkX that is injected into infected cells by a Type IV secretion system transfers a phospho …
Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor.
Oesterlin LK, Goody RS, Itzen A. Oesterlin LK, et al. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5621-6. doi: 10.1073/pnas.1121161109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411835 Free PMC article.
While there is strong evidence that DrrA, as a bacterially encoded GDP/GTP exchange factor, contributes to this event, we show here that posttranslational modifications of Rabs can also modulate the affinity for GDI and thus cause effective displacement of GDI from Rab:GDI …
While there is strong evidence that DrrA, as a bacterially encoded GDP/GTP exchange factor, contributes to this event, we show here t …
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