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Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant.
Minematsu T, Iwai M, Umehara K, Usui T, Kamimura H. Minematsu T, et al. Among authors: iwai m. Drug Metab Dispos. 2010 Jan;38(1):1-4. doi: 10.1124/dmd.109.028142. Drug Metab Dispos. 2010. PMID: 19833842
Carrier-mediated uptake of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small-molecule survivin suppressant, into human solid tumor and lymphoma cells.
Minematsu T, Iwai M, Sugimoto K, Shirai N, Nakahara T, Usui T, Kamimura H. Minematsu T, et al. Among authors: iwai m. Drug Metab Dispos. 2009 Mar;37(3):619-28. doi: 10.1124/dmd.108.025254. Epub 2008 Dec 4. Drug Metab Dispos. 2009. PMID: 19056913
741 results