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An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity.
Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S. Kondo Y, et al. Among authors: iwao t. Drug Metab Pharmacokinet. 2014;29(3):237-43. doi: 10.2133/dmpk.dmpk-13-rg-104. Epub 2013 Dec 10. Drug Metab Pharmacokinet. 2014. PMID: 24334537 Free PMC article.
Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.
Kondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, Matsunaga T. Kondo Y, et al. Among authors: iwao t. PLoS One. 2014 Aug 1;9(8):e104010. doi: 10.1371/journal.pone.0104010. eCollection 2014. PLoS One. 2014. PMID: 25084468 Free PMC article.
Inhibition of mitogen-activated protein kinase kinase, DNA methyltransferase, and transforming growth factor-β promotes differentiation of human induced pluripotent stem cells into enterocytes.
Kodama N, Iwao T, Kabeya T, Horikawa T, Niwa T, Kondo Y, Nakamura K, Matsunaga T. Kodama N, et al. Among authors: iwao t. Drug Metab Pharmacokinet. 2016 Jun;31(3):193-200. doi: 10.1016/j.dmpk.2016.02.002. Epub 2016 Feb 17. Drug Metab Pharmacokinet. 2016. PMID: 27161454
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