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Biochemical and molecular aspects of genetic disorders of bilirubin metabolism.

Iyanagi T, Emi Y, Ikushiro S. Iyanagi T, et al. Biochim Biophys Acta. 1998 Sep 30;1407(3):173-84. doi: 10.1016/s0925-4439(98)00044-1. Biochim Biophys Acta. 1998. PMID: 9748558 Review.

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Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex.

Emi Y, Ikushiro S, Iyanagi T. Emi Y, et al. Among authors: iyanagi t. J Biol Chem. 1996 Feb 16;271(7):3952-8. doi: 10.1074/jbc.271.7.3952. J Biol Chem. 1996. PMID: 8632018

We have isolated genomic DNA clones containing rat UDP-glucuronosyltransferase family 1 (UGT1) sequences and have shown drug-responsive and tissue-specific alternative expression of multiple first exons (Emi, Y., Ikushiro, S., and Iyanagi, T. (1995) J. Biochem. (Tok …

We have isolated genomic DNA clones containing rat UDP-glucuronosyltransferase family 1 (UGT1) sequences and have shown drug-responsive and …

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Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat).

Iyanagi T. Iyanagi T. J Biol Chem. 1991 Dec 15;266(35):24048-52. J Biol Chem. 1991. PMID: 1748678

We have demonstrated that the defect of the isoenzyme for 4-nitrophenol (4NP) in Gunn rat liver arises from a -1 frameshift mutation that removes 115 amino acids from the COOH terminus (Iyanagi, T., Watanabe, T., and Uchiyama, Y. (1989) J. Biol. Chem. 264, 21 …

We have demonstrated that the defect of the isoenzyme for 4-nitrophenol (4NP) in Gunn rat liver arises from a -1 frameshift mutation that re …

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Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver.

Kishi M, Emi Y, Sakaguchi M, Ikushiro S, Iyanagi T. Kishi M, et al. Among authors: iyanagi t. Biochem Biophys Res Commun. 2008 Dec 19;377(3):815-9. doi: 10.1016/j.bbrc.2008.10.043. Epub 2008 Oct 18. Biochem Biophys Res Commun. 2008. PMID: 18938141

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Transcriptional enhancement of UDP-glucuronosyltransferase form 1A2 (UGT1A2) by nuclear factor I-A (NFI-A) in rat hepatocytes.

Emi Y, Ueda K, Ohnishi A, Ikushiro S, Iyanagi T. Emi Y, et al. Among authors: iyanagi t. J Biochem. 2005 Sep;138(3):313-25. doi: 10.1093/jb/mvi128. J Biochem. 2005. PMID: 16169882

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[Genetic defect of bilirubin-glucuronosyltransferase].

Iyanagi T. Iyanagi T. Seikagaku. 2003 Mar;75(3):234-41. Seikagaku. 2003. PMID: 12704845 Review. Japanese. No abstract available.

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Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes.

Ikushiro S, Sahara M, Emi Y, Yabusaki Y, Iyanagi T. Ikushiro S, et al. Among authors: iyanagi t. Biochim Biophys Acta. 2004 May 3;1672(2):86-92. doi: 10.1016/j.bbagen.2004.02.012. Biochim Biophys Acta. 2004. PMID: 15110090

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Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.

Emi Y, Omura S, Ikushiro S, Iyanagi T. Emi Y, et al. Among authors: iyanagi t. Arch Biochem Biophys. 2002 Sep 15;405(2):163-9. doi: 10.1016/s0003-9861(02)00351-x. Arch Biochem Biophys. 2002. PMID: 12220528

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Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6.

Ikushiro S, Emi Y, Iyanagi T. Ikushiro S, et al. Among authors: iyanagi t. Biochemistry. 2002 Oct 22;41(42):12813-20. doi: 10.1021/bi0262451. Biochemistry. 2002. PMID: 12379124

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Molecular mechanism of metabolic NAD(P)H-dependent electron-transfer systems: The role of redox cofactors.

Iyanagi T. Iyanagi T. Biochim Biophys Acta Bioenerg. 2019 Mar 1;1860(3):233-258. doi: 10.1016/j.bbabio.2018.11.014. Epub 2018 Nov 9. Biochim Biophys Acta Bioenerg. 2019. PMID: 30419202 Free article. Review.

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