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Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.
Lebecque SG, Gearhart PJ. Lebecque SG, et al. J Exp Med. 1990 Dec 1;172(6):1717-27. doi: 10.1084/jem.172.6.1717. J Exp Med. 1990. PMID: 2258702 Free PMC article.
The 3' boundary was approximately 1 kb from the V(D)J gene and was not associated with a DNA sequence motif. Occasional mutations were located in the nuclear matrix association and enhancer regions. ...
The 3' boundary was approximately 1 kb from the V(D)J gene and was not associated with a DNA sequence motif. Occasional mutations wer …
Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1.
Wallick SC, Figari IS, Morris RE, Levinson AD, Palladino MA. Wallick SC, et al. J Exp Med. 1990 Dec 1;172(6):1777-84. doi: 10.1084/jem.172.6.1777. J Exp Med. 1990. PMID: 2258706 Free PMC article.
Using recombinant DNA technology, we have generated Chinese hamster ovary (CHO) cell lines that synthesize latent transforming growth factor beta 1 (TGF-beta 1) to study immune regulation by TGF-beta 1. ...In vivo, serum from nu/nu mice bearing CHO/TGF-beta …
Using recombinant DNA technology, we have generated Chinese hamster ovary (CHO) cell lines that synthesize latent transforming growth factor …
The TL region gene 37 encodes a Qa-1 antigen.
Wolf PR, Cook RG. Wolf PR, et al. J Exp Med. 1990 Dec 1;172(6):1795-804. doi: 10.1084/jem.172.6.1795. J Exp Med. 1990. PMID: 2258708 Free PMC article.
Of all the biochemically defined mouse MHC class I molecules, the Qa-1 antigens are the only ones for which a gene has not been identified. ...Immunoprecipitation and polyacrylamide gel electrophoresis analysis of the molecules reactive with anti-Qa-1 and anti-37 se …
Of all the biochemically defined mouse MHC class I molecules, the Qa-1 antigens are the only ones for which a gene has not been ident …
Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.
Petrie HT, Hugo P, Scollay R, Shortman K. Petrie HT, et al. J Exp Med. 1990 Dec 1;172(6):1583-8. doi: 10.1084/jem.172.6.1583. J Exp Med. 1990. PMID: 2147945 Free PMC article.
However, these Pgp-1- IL-2R alpha+ precursors do not differentiate further in unstimulated culture. The more mature Pgp-1- IL-2R alpha- CD3-4-8- subset becomes primarily CD3lo4+ 8+ within 1 d after transplantation, and some mature single-positive progeny are …
However, these Pgp-1- IL-2R alpha+ precursors do not differentiate further in unstimulated culture. The more mature Pgp-1- IL- …
Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.
Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD, Coligan JE, Kehrl JH, Fauci AS. Ehrenreich H, et al. J Exp Med. 1990 Dec 1;172(6):1741-8. doi: 10.1084/jem.172.6.1741. J Exp Med. 1990. PMID: 1701822 Free PMC article.
Cultured human macrophages were found by immunocytochemistry to stain positively for endothelin 1 and endothelin 3. Their capability to produce and release these peptides was confirmed by a combination of reverse-phase high-performance liquid chromatography and radioimmuno …
Cultured human macrophages were found by immunocytochemistry to stain positively for endothelin 1 and endothelin 3. Their capability …
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Wachter H. Werner-Felmayer G, et al. J Exp Med. 1990 Dec 1;172(6):1599-607. doi: 10.1084/jem.172.6.1599. J Exp Med. 1990. PMID: 2124251 Free PMC article.
The effect of IFN-gamma is drastically increased by cotreatment with tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), or lipopolysaccharide (LPS). ...The cytotoxic effect of combinations of IFN-alpha with TNF-gamma, IL-1, or LPS is attenuated by …
The effect of IFN-gamma is drastically increased by cotreatment with tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1
The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter.
Granelli-Piperno A, Nolan P, Inaba K, Steinman RM. Granelli-Piperno A, et al. J Exp Med. 1990 Dec 1;172(6):1869-72. doi: 10.1084/jem.172.6.1869. J Exp Med. 1990. PMID: 1701825 Free PMC article.
While dexamethasone markedly blocks the increase in IL-2 mRNA in stimulated human blood T cells, we found that the drug does not block the appearance of factors that bind to the transcriptional control sites termed AP-1, AP-3, NF-kB, OCT-1, B site, and NF-AT. In con …
While dexamethasone markedly blocks the increase in IL-2 mRNA in stimulated human blood T cells, we found that the drug does not block the a …
Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders.
Heslop HE, Bianchi AC, Cordingley FT, Turner M, Chandima W, De Mel CP, Hoffbrand AV, Brenner MK. Heslop HE, et al. J Exp Med. 1990 Dec 1;172(6):1729-34. doi: 10.1084/jem.172.6.1729. J Exp Med. 1990. PMID: 2258703 Free PMC article.
The B lymphoproliferative disorders B chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) produce a number of autocrine growth factors, including tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-1, all of which may induce positive feedback growth lo …
The B lymphoproliferative disorders B chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) produce a number of autocrine growt …
The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.
Weiss U, Rajewsky K. Weiss U, et al. J Exp Med. 1990 Dec 1;172(6):1681-9. doi: 10.1084/jem.172.6.1681. J Exp Med. 1990. PMID: 2124253 Free PMC article.
The anti-(4-hydroxy-3-nitro-phenyl)acetyl (NP) response is dominated by lambda 1 chain-bearing antibodies expressing the VH gene V186.2 in combination with the D element DFL16.1. lambda 1-positive B cells were isolated from the spleens of mice immunized with …
The anti-(4-hydroxy-3-nitro-phenyl)acetyl (NP) response is dominated by lambda 1 chain-bearing antibodies expressing the VH gene V186 …
Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.
Ezekowitz RA, Sastry K, Bailly P, Warner A. Ezekowitz RA, et al. J Exp Med. 1990 Dec 1;172(6):1785-94. doi: 10.1084/jem.172.6.1785. J Exp Med. 1990. PMID: 2258707 Free PMC article.
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