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Page 1
Variants at the APOE /C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol.
Low-Kam C, Rhainds D, Lo KS, Barhdadi A, Boulé M, Alem S, Pedneault-Gagnon V, Rhéaume E, Dubé MP, Busseuil D, Hegele RA, Lettre G, Tardif JC. Low-Kam C, et al. J Am Heart Assoc. 2018 Aug 21;7(16):e009545. doi: 10.1161/JAHA.118.009545. J Am Heart Assoc. 2018. PMID: 30369316 Free PMC article.
Five of these loci harbor genes with important roles in lipid biology ( CETP , LIPC , LPL , APOA 1/C3/A4/A5, and APOE /C1/C2/C4). Except for the APOE /C1/C2/C4 variant ( rs141622900, P (nonadjusted)=1.010(-11); P (adjusted)=8.810(-9)), the association signals disapp …
Five of these loci harbor genes with important roles in lipid biology ( CETP , LIPC , LPL , APOA 1/C3/A4/A5, and APOE /C1/C2/C …
Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.
Dashti HS, Shea MK, Smith CE, Tanaka T, Hruby A, Richardson K, Wang TJ, Nalls MA, Guo X, Liu Y, Yao J, Li D, Johnson WC, Benjamin EJ, Kritchevsky SB, Siscovick DS, Ordovás JM, Booth SL. Dashti HS, et al. Am J Clin Nutr. 2014 Dec;100(6):1462-9. doi: 10.3945/ajcn.114.093146. Epub 2014 Oct 8. Am J Clin Nutr. 2014. PMID: 25411281 Free PMC article.
These SNPs are on 5 independent loci on 11q23.3, 8q24.3, 5q22.3, 2p12, and 19p13.12, and they fall within or near the candidate genes APOA1/C3/A4/A5 cluster (involved in lipoprotein metabolism), COL22A1, CDO1, CTNAA2, and CYP4F2 (a phylloquinone oxidase), respective …
These SNPs are on 5 independent loci on 11q23.3, 8q24.3, 5q22.3, 2p12, and 19p13.12, and they fall within or near the candidate genes APOA1/ …
Mutation screening of the APOA5 gene in subjects with coronary artery disease.
Soufi M, Sattler AM, Kurt B, Schaefer JR. Soufi M, et al. J Investig Med. 2012 Oct;60(7):1015-9. doi: 10.2310/JIM.0b013e3182686918. J Investig Med. 2012. PMID: 22914599
Apolipoprotein A5 (APOA5) is a member of the apolipoprotein APOA1/C3/A4/A5 gene cluster and a major determinant of plasma triglyceride levels in the population. ...
Apolipoprotein A5 (APOA5) is a member of the apolipoprotein APOA1/C3/A4/A5 gene cluster and a major determinant of plasma trig …
APOA4 polymorphism as a risk factor for unfavorable lipid serum profile and depression: a cross-sectional study.
Ota VK, Chen ES, Ejchel TF, Furuya TK, Mazzotti DR, Cendoroglo MS, Ramos LR, Araujo LQ, Burbano RR, Smith Mde A. Ota VK, et al. J Investig Med. 2011 Aug;59(6):966-70. doi: 10.2310/JIM.0b013e31822467cd. J Investig Med. 2011. PMID: 21712729
INTRODUCTION: APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. ...Haplotype analyses found an association between His/C/C haplotype (Gln360His/-482C&g …
INTRODUCTION: APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated …
Distant neighbor base sequence context effects in human nucleotide excision repair of a benzo[a]pyrene-derived DNA lesion.
Cai Y, Kropachev K, Xu R, Tang Y, Kolbanovskii M, Kolbanovskii A, Amin S, Patel DJ, Broyde S, Geacintov NE. Cai Y, et al. J Mol Biol. 2010 Jun 11;399(3):397-409. doi: 10.1016/j.jmb.2010.04.004. Epub 2010 Apr 22. J Mol Biol. 2010. PMID: 20399214 Free PMC article.
We constructed two duplexes containing the same minor groove-aligned 10S (+)-trans-anti-B[a]P-N(2)-dG (G*) DNA adduct, derived from the environmental carcinogen benzo[a]pyrene (B[a]P): 5'-C-C-A-T-C-G*-C-T-A-C-C-3' (CG*C-I), and 5'-C-A-C3-A4-C5-G*-C-A-C …
We constructed two duplexes containing the same minor groove-aligned 10S (+)-trans-anti-B[a]P-N(2)-dG (G*) DNA adduct, derived from the envi …
Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men.
Delgado-Lista J, Perez-Jimenez F, Ruano J, Perez-Martinez P, Fuentes F, Criado-Garcia J, Parnell LD, Garcia-Rios A, Ordovas JM, Lopez-Miranda J. Delgado-Lista J, et al. J Lipid Res. 2010 Jan;51(1):63-73. doi: 10.1194/jlr.M800527-JLR200. J Lipid Res. 2010. PMID: 19592705 Free PMC article.
The APOA1/C3/A4/A5 gene cluster encodes important regulators of fasting lipids, but the majority of lipid metabolism takes place in the postprandial state and knowledge about gene regulation in this state is scarce. ...We have identified new associations between SNP …
The APOA1/C3/A4/A5 gene cluster encodes important regulators of fasting lipids, but the majority of lipid metabolism takes pla …
Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster.
Mishiro T, Ishihara K, Hino S, Tsutsumi S, Aburatani H, Shirahige K, Kinoshita Y, Nakao M. Mishiro T, et al. EMBO J. 2009 May 6;28(9):1234-45. doi: 10.1038/emboj.2009.81. Epub 2009 Mar 26. EMBO J. 2009. PMID: 19322193 Free PMC article.
Long-range regulatory elements and higher-order chromatin structure coordinate the expression of multiple genes in cluster, and CTCF/cohesin-mediated chromatin insulator may be a key in this regulation. The human apolipoprotein (APO) A1/C3/A4/A5 gene region, whose a …
Long-range regulatory elements and higher-order chromatin structure coordinate the expression of multiple genes in cluster, and CTCF/cohesin …
Determinants of plasma apolipoprotein A-V and APOA5 gene transcripts in humans.
Hahne P, Krempler F, Schaap FG, Soyal SM, Höffinger H, Miller K, Oberkofler H, Strobl W, Patsch W. Hahne P, et al. J Intern Med. 2008 Nov;264(5):452-62. doi: 10.1111/j.1365-2796.2008.01987.x. Epub 2008 Jun 3. J Intern Med. 2008. PMID: 18537870 Free PMC article.
DESIGN: We determined influences of anthropometric variables, biochemical factors related to lipid and glucose metabolism, hepatic mRNA levels transcribed from the APOA1/C3/A4/A5 cluster and transcription factor genes implicated in the regulation of APOA5 as well as …
DESIGN: We determined influences of anthropometric variables, biochemical factors related to lipid and glucose metabolism, hepatic mRNA leve …
Apoprotein A-V: an important regulator of triglyceride metabolism.
Kluger M, Heeren J, Merkel M. Kluger M, et al. J Inherit Metab Dis. 2008 Apr;31(2):281-8. doi: 10.1007/s10545-008-0863-4. Epub 2008 Apr 14. J Inherit Metab Dis. 2008. PMID: 18415697 Review.
Apolipoprotein A-V (apoA-V) was discovered in 2001 both by comparative sequencing and as a liver regeneration protein. The gene is a located at the APOA1/C3/A4/A5 gene cluster on chromosome 11q23, a locus well known for playing a major role in regulating plasma chol …
Apolipoprotein A-V (apoA-V) was discovered in 2001 both by comparative sequencing and as a liver regeneration protein. The gene is a located …
Evolutionary rate heterogeneity of Alu repeats upstream of the APOA5 gene: do they regulate APOA5 expression?
Ruiz-Narváez EA, Campos H. Ruiz-Narváez EA, et al. J Hum Genet. 2008;53(3):247-253. doi: 10.1007/s10038-008-0245-7. Epub 2008 Jan 12. J Hum Genet. 2008. PMID: 18193158
The APOA5 gene, located in the APOA1/C3/A4/A5 gene cluster, is a key regulator of triglyceride metabolism. ...Alu repeats with lower substitution rate tended to be located up to 14-kb upstream of the APOA5 gene, to belong to the oldest J-family and to have an …
The APOA5 gene, located in the APOA1/C3/A4/A5 gene cluster, is a key regulator of triglyceride metabolism. ...Alu repeats with …
15 results